Anti-Sd^a, a New Blood Group Antibody

Renton, P.H.; Howell, P.; Ikin, Elizabeth W.; Giles, Carolyn M.; Goldsmith, K.L.G.

doi:10.1159/000466498

Cited by 18 publications

(22 citation statements)

References 4 publications

(4 reference statements)

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“…The Sda-blood-group determinant is carried on the erythrocytes of about 92% of individuals and is the sole antigen of the Sid blood-group system (Macvie et al, 1967;Renton et al, 1967). The urine of Sd(a +) persons also shows Sda activity (Morton & Terry, 1970), and the major carrier of the urinary Sda determinant has been shown (Soh et al, 1979) to be the T-H glycoproteir (Tamm & Horsfall, 1950), of which it is an integral part.…”

Section: Introductionmentioning

confidence: 99%

Oligosaccharides obtained from a blood-group-Sd(a+) Tamm-Horsfall glycoprotein. An n.m.r. study

Donald¹,

Feeney²

1986

Biochemical Journal

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Treatment of Tamm-Horsfall urinary glycoprotein with Bacteroides fragilis endo-,J-galactosidase over a range of enzyme concentrations, pH and temperature resulted in the release of a small but constant proportion of the terminal sugars, which indicates the presence in the glycoprotein of relatively few enzyme-susceptible -GIcNAc8l-3Gal,/l-4GlcNAc-units. Three oligosaccharides were isolated from the enzyme digest and characterized as Galfl6-4GlcNAcfll-3Gal (I), NeuAcz2-3Gal/J1-4 GlcNAcf6l-3Gal (II) and GalNAcfll-4(NeuAca2-3)Gal/J1-4GlcNAc,81-3Gal (III) by methylation analysis and exo-glycosidase digestion. The alditols of these oligosaccharides and related structures were examined by 500 MHz 'H-n.m.r. spectroscopy aided by spin-spin decoupling and two-dimensional correlated spectroscopy. An almost complete assignment of proton shifts was possible, and significant differences between the signals of some of the protons in the blood-group-Sda-active oligosaccharide III and literature values for the corresponding signals in the structurally related Cad-blood-group determinant are noted. INTRODUCTIONThe Sda-blood-group determinant is carried on the erythrocytes of about 92% of individuals and is the sole

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Section: Introductionmentioning

confidence: 99%

Oligosaccharides obtained from a blood-group-Sd(a+) Tamm-Horsfall glycoprotein. An n.m.r. study

Donald¹,

Feeney²

1986

Biochemical Journal

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“…In general, patients with anti-Sda do not de velop hemolysis even when transfused with Sda-antigenpositive blood [1][2][3]. Our patient experienced a mild reac tion, possibly because the RBCs from one donor unit strongly expressed Sda antigen.…”

Section: Discussionmentioning

confidence: 92%

A Hemolytic Reaction Implicating Sd^a Antibody Missed by Immediate Spin Crossmatch

Reznicek

Cordle

Strauss³

1992

Vox Sanguinis

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Anti-Sd^a, an antibody not usually considered to cause of hemolytic transfusion reactions, possibly was related to hemolysis following transfusion of red blood cells expressing strong Sd^a antigen. Prior to transfusion, the antiglobulin antibody screen performed in LISS and an immediate spin crossmatch were negative. Retrospectively, after hemolysis was detected, an antiglobulin crossmatch with red cells from the transfused unit revealed microscopic incompatibility. The transfused unit proved to have strong expression of Sd^a antigen - facilitating identification of a weak Sd^a antibody in our patient. In addition, this case represents an unusual instance in which an antibody screen plus an immediate spin crossmatch failed to detect an incompatibility that would have been apparent had an antiglobulin crossmatch been performed.

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“…The fact that the L antigen was present in all saliva of nonsecretors excludes the ABH and the Leb antigens. Bombay type individuals usually possess the Lea [14], the Sda [15] and the I antigens [2] but lack the L antigen in saliva and red cells [5]. Consequently, the Lea, Sda and the I antigens are different from the L antigen.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a Human Saliva Antigen Precipitated by a Lectin from Lotus tetragonolobus

Napier¹,

Everhart²,

Grundbacher³

1974

Vox Sanguinis

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Ouchterlony precipitin tests give visual evidence that extracts from Lotus tetragonolobus contain two different lectins. In addition to the H antigen, Lotus identifies another antigen, called the L antigen, which is not the A, B, Le^a, Sd^a, I or SC(1) saliva antigen and has been found in variable strength in secretor and nonsecretor saliva of individuals of all ABO blood groups. The L antigen is part of a cathode migrating glycoprotein. Sugar inhibition studies reveal that the terminal sugars are the same as for the H and Le^a antigens, the presumable difference being that L-fucose is attached to a different site. The L antigen is absent in the saliva and red cells of the Bombay type, but red cells of all other individuals absorb both lectins from Lotus extract.

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Anti-Sd^a, a New Blood Group Antibody

Cited by 18 publications

References 4 publications

Oligosaccharides obtained from a blood-group-Sd(a+) Tamm-Horsfall glycoprotein. An n.m.r. study

Oligosaccharides obtained from a blood-group-Sd(a+) Tamm-Horsfall glycoprotein. An n.m.r. study

A Hemolytic Reaction Implicating Sd^a Antibody Missed by Immediate Spin Crossmatch

Characterization of a Human Saliva Antigen Precipitated by a Lectin from Lotus tetragonolobus

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