Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells

Schneider, Yann; Vincent, Florence; Duranton, B; Badolo, Lassina; Gossé, Francine; Bergmann, Christian; Seiler, Nikolaus; Raul, Françis

doi:10.1016/s0304-3835(00)00511-5

Cited by 305 publications

(170 citation statements)

References 30 publications

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“…21 Doses required for RSV to induce growth inhibition and S-phase arrest in colon cancer cells were reported in the lower range of 25-50 μM, whereas a higher dosage of 200 μM or more was necessary to elicit apoptosis. 22,23 Consistent with previous studies, our data showed that RSV alone promoted S-phase arrest of the colon cancer cells. Intuitively, it may thus seem that RSV-evoked S-phase arrest is likely to enhance 5-FU evoked apoptosis.…”

Section: Discussionsupporting

confidence: 92%

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Chan

Phoo²,

Clément³

et al. 2008

Cancer Biology & Therapy

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Section: Discussionsupporting

confidence: 92%

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Chan

Phoo²,

Clément³

et al. 2008

Cancer Biology & Therapy

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“…2,3,44,45 From these studies, it was found that RES induced cell death and that, in certain cell types, it involved an apoptotic mechanism. 3,4,46 The importance of RES in cancer was further supported by in vivo data revealing that this molecule could inhibit skin 5 and mammary gland 6 tumor formation in mice and rats, respectively.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol‐induced apoptosis in MCF‐7 human breast cancer cells involves a caspase‐independent mechanism with downregulation of Bcl‐2 and NF‐κB

Pozo‐Guisado

Merino

Mulero‐Navarro

et al. 2005

Intl Journal of Cancer

205

143

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Resveratrol (RES), a chemopreventive molecule, inhibits the proliferation of tumor cells of different etiologies. We previously showed that RES alters the cell cycle and induces apoptosis in MCF-7 breast tumor cells by interfering with the estrogen receptor (ERa)-dependent phosphoinositide 3-kinase (PI3K) pathway. Here, we analyzed signaling downstream of PI3K, to understand the mechanisms of RES-induced apoptosis. Apoptotic death by RES in MCF-7 was mediated by Bcl-2 downregulation since overexpression of this protein abolished apoptosis. Decreased Bcl-2 levels were not related to cytochrome c release, activation of caspases 3/8 or poly(ADP-ribose) polymerase proteolysis. However, RES decreased mitochondrial membrane potential and increased reactive oxygen species and nitric oxide production. NF-kB, a regulator of Bcl-2 expression, and calpain protease activity, a regulator of NF-kB, were both inhibited by RES. The patterns for NFkB and calpain activities followed that of PI3K and were inhibited by LY294002. NF-kB inhibition coincided with diminished MMP-9 activity and cell migration. These data suggest that RES-induced apoptosis in MCF-7 could involve an oxidative, caspase-independent mechanism, whereby inhibition of PI3K signaling converges to Bcl-2 through NF-kB and calpain protease activity. Therefore, Bcl-2 and NF-kB could be considered potential targets for the chemopreventive activity of RES in estrogen-responsive tumor cells. ' 2005 Wiley-Liss, Inc.Key words: resveratrol; caspase; Bcl-2; NF-kB; apoptosis Among natural compounds with beneficial effects on human health, RES (3,4 0 ,5-trihydroxystilbene) has attracted considerable interest. This molecule, present at relevant concentrations in red wine, 1 has been associated with a lower incidence of cardiovascular disease. Different studies have also suggested a beneficial effect of RES in cancer since it inhibits proliferation and promotes death in tumor cell lines of different origins, 2-4 and, in vivo, suppresses the formation of skin 5 and mammary gland 6 tumors in rodent models of carcinogenesis.We, as well as other laboratories, have found that the ability of RES to inhibit cell viability and proliferation in the human breast cancer cell lines MCF-7 and MDA-MB-231 was unrelated to ERa status. 7,8 However, apoptotic cell death was present only in ERapositive MCF-7 and involved cell-specific regulation of the G 1 /S and G 2 /M transitions of the cell cycle. 2,8 RES properties are related to ERa since this compound has estrogenic or antiestrogenic activities depending on its concentration and the phenotype of the target cell. 9,10 ERa, in addition to its nuclear role as a transcription factor, is involved in regulating the PI3K pathway, which controls cell growth, proliferation and apoptosis. [11][12][13] In MCF-7 cells, RES induced a biphasic pattern of PI3K activity that increased at low concentrations and decreased at high concentrations. Activation of downstream PI3K effectors PKB/AKT and GSK-3 closely followed the pattern of PI3K activity. 14 The ...

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“…Consequently, resveratrol has been extensively studied, and numerous beneficial effects have been observed, including antithrombotic, cardioprotective, anti-inflammatory, antioxidative, and vasorelaxant effects (Bhat et al, 2001;Delmas et al, 2005;KasdallahGrissa et al, 2007;Stef et al, 2006;). In addition, resveratrol exhibits antitumor properties in several cancer types, including prostate, mammary, colon, and lung cancers (Bhat and Pezzuto, 2002;Revel et al, 2003;Schneider et al, 2000;Stewart et al, 2003). The anticancer effects of resveratrol are associated with its ability to suppress proliferation and induce apoptosis through a variety of different pathways in tumor cell lines (Aggarwal et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Alters microRNA Expression Profiles in A549 Human Non-Small Cell Lung Cancer Cells

Bae

Lee

Jun

et al. 2011

Molecules and Cells

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Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells

Cited by 305 publications

References 30 publications

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Resveratrol‐induced apoptosis in MCF‐7 human breast cancer cells involves a caspase‐independent mechanism with downregulation of Bcl‐2 and NF‐κB

Resveratrol Alters microRNA Expression Profiles in A549 Human Non-Small Cell Lung Cancer Cells

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