Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Chan, Jason Yongsheng; Phoo, Meng Seng; Clément, Marie‐Véronique; Pervaiz, Shazib; Lee, Shao Chin

doi:10.4161/cbt.7.8.6302

Cited by 62 publications

(42 citation statements)

References 19 publications

(28 reference statements)

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“…(40) In addition, our results show that Nr-CAM overexpression was associated with p53 expression, which is known to be associated with apoptotic resistance in colon cancer cells. (41) Indeed, it may be speculated that Nr-CAM overexpression confers resistance to 5-FU-evoked apoptosis in CRC cells. Nonetheless, as Nr-CAM overexpression is correlated with disease stage, it remains to be examined in larger studies if there exists a differential response to 5-FU-based chemotherapy at various stages of disease progression.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of neurone glial‐related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer

2011

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A downstream target of the Wnt pathway, neurone glial-related cell adhesion molecule (Nr-CAM) has recently been implicated in human cancer development. However, its role in colorectal cancer (CRC) pathobiology and clinical relevance remains unknown. In this study, we examined the clinical significance of Nr-CAM protein expression in a retrospective series of 428 CRCs using immunohistochemistry and tissue microarrays. Cox proportional hazards regression was used to calculate hazard ratios (HR) of mortality according to various clinicopathological features and molecular markers. All CRC samples were immunoreactive for Nr-CAM protein expression, compared to 10 ⁄ 245 (4%) matched normal tissue (P < 0.0001). Of 428 CRC samples, 97 (23%) showed Nr-CAM overexpression, which was significantly associated with nodal (P = 0.012) and distant (P = 0.039) metastasis, but not with extent of local invasion or tumor size. Additionally, Nr-CAM overexpression was associated with vascular invasion (P = 0.0029), p53 expression (P = 0.036), and peritoneal metastasis at diagnosis (P = 0.013). In a multivariate model adjusted for other clinicopathological predictors of survival, Nr-CAM overexpression correlated with a significant increase in disease-specific (HR 1.66; 95% confidence interval 1.11-2.47; P = 0.014) and overall mortality (HR 1.57; 95% confidence interval 1.07-2.30; P = 0.

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Section: Discussionmentioning

confidence: 99%

Overexpression of neurone glial‐related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer

2011

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“…1,2 Resveratrol inhibits cancer cell growth in many cell lines, including cancers of the lung, prostate, colon, breast and ovaries. [3][4][5][6][7][8][9][10][11][12][13][14] Resveratrol also reduces tumor incidence in animal models by interfering with carcinogenesis through a wide array of anti-cancer actions. Several animal studies have demonstrated the ability of resveratrol to inhibit prostate cancer development by downregulating androgen receptors, inducing apoptosis/cell cycle arrest and inhibiting disease progression.…”

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confidence: 99%

Red wine consumption and risk of prostate cancer: The California Men's Health Study

Chao

Haque

Eeden

et al. 2009

Intl Journal of Cancer

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Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine intake on the risk of prostate cancer using data prospectively collected in the California Men's Health Study (CMHS). CMHS is a multiethnic cohort of 84,170 men aged 45-69 years who were members of the Kaiser Permanente Southern and Northern California Health Plans. Information on demographic and lifestyle factors was collected using mailed questionnaires between 2002 and 2003. We used Cox models to estimate the effect of red wine on prostate cancer risk, adjusting for potential confounders. A total of 1,340 incident prostate cancer cases identified from Surveillance, Epidemiology and End Result-affiliated cancer registries were included in the analyses. We did not find a clear association between red wine intake and risk of prostate cancer. Hazard ratio (HR) estimates for consuming <1 drink/week, 1 drink/week but <1 drink/day and 1 drink/day were 0.89, 95% confidence interval (0.74-1.07), 0.99 (0.83-1.17) and 0.88 (0.70-1.12), respectively. Further, we observed no linear dose response. The lack of association for red wine intake was consistently observed when we restricted the analyses to those with and without a history of PSA screening. In addition, we also did not observe any association with prostate cancer for beer, white wine, liquor or combined alcoholic beverage intake (HR for combined alcoholic beverage intake of 5 drinks/day 5 1.16 (0.83-1.63). Neither red wine nor total alcohol consumption were associated with prostate cancer risk in this population of moderate drinkers.Red wine is a rich source of polyphenol antioxidants such as resveratrol. Recently, resveratrol has received considerable attention because of its potent anti-cancer properties.

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“…The effect of resveratrol on fluorouracil-triggered apoptosis has been shown to hinge on the cellular p53 status (Chan et al 2008). Likewise, we have recently observed that the SIRT1/2 inhibitor tenovin-1 effectively killed p53 +/+ , but not p53 −/− cancer cells (Sonnemann et al 2014), further substantiating that the effects of sirtuin modulators can depend on p53.…”

Section: Single-agent Activity Of Resveratrol and Srt1720 Against Ewimentioning

confidence: 55%

“…These inconsistent findings might be due to diverse model systems, but they might as well be due to the use of different concentrations of resveratrol and/or divergent cellular p53 status. The latter consideration is supported by a publication which showed that resveratrol at lower concentrations antagonized the cytotoxic activity of fluorouracil in p53 +/+ , but not in p53 −/− colon cancer cells; in contrast, resveratrol amplified fluorouracil-mediated cell death at higher concentrations independent of p53 (Chan et al 2008).…”

Section: Introductionmentioning

confidence: 83%

Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing’s sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity

Sonnemann

Kahl

Siranjeevi

et al. 2015

J Cancer Res Clin Oncol

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Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Cited by 62 publications

References 19 publications

Overexpression of neurone glial‐related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer

Overexpression of neurone glial‐related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer

Red wine consumption and risk of prostate cancer: The California Men's Health Study

Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing’s sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity

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