Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss

Paciello, Fabiola; Pino, Antonella; Rolesi, Rolando; Troiani, Diana; Paludetti, Gaetano; Grassi, Claudio; Fetoni, Anna Rita

doi:10.1016/j.fct.2020.111555

Cited by 53 publications

(34 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The contents of chlorogenic acid (110), caffeic acid (111) and protocatechuic acid (115) are higer. These phenolic compounds possess many health-promoting properties, including antioxidant, antiinflammatory, antidiabetic, and antihypertensive activities ( Al-Megrin et al, 2020 ; Paciello et al, 2020 ; El-Sonbaty et al, 2019 ; Li et al, 2020 ). For example, protocatechuic acid administration for twelve-week could improves insulin-induced vasorelaxation in aging spontaneously hypertensive rats.…”

Section: Phytochemistrymentioning

confidence: 99%

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

Gong

Zou

Zheng

et al. 2021

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological relevance Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. ( PS ) and Patrinia villosa Juss. ( PV ) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry. Aim of the review This paper aims to comprehensively outline the traditional uses, botanical description, phytochemistry, pharmacology, toxicology, quality control, pharmacokinetics and patents of Herba Patriniae, and elaborate the same/different characteristics between PS and PV . Materials and methods Detailed information of Herba Patriniae was collected from various online databases (Pubmed, Web of Science, Google Schola, China National Knowledge Infrastructure Database, National Intellectual Property Administration, PRC National Medical Products Administration), and those published resources (M.Sc. Thesis and books). Results A total of 233 compounds have been identified in Herba Patriniae, including triterpenoid saponins, flavonoids, organic acids, iridoids, and volatiles. A very distinct difference was observed, that PS is rich in triterpenoid saponins and volatiles, while PV contains more flavonoids. Two source species of Herba Patriniae gave similar pharmacological effects on anti-cancer, anti-inflammatory, antioxidant, antimicrobial, sedative and hypnotic effects. But there were no reports were on antipruritic, proangiogenic and anti-diarrheal effects for PS , and no studies on anti-diabetic effects for PV . Generally, Herba Patriniae showed non-toxic in the clinical dose, but mild side effects, such as temporary leukopenia, dizziness and nausea, could be found when large and excessive dosage is used. A variety of compounds have been quantified for the quality control of PS and PV . The variety, growth environment, growth time, and harvest time not only affected the contents but also the pharmacological activities of the bioactive compounds. In the past year, patents for compositions containing PV and PS have been filed, mainly involving human health, hygiene, agriculture, and animal husbandry. Unfortunately, the research on pharmacokinetics is insufficient. Only the prototype components and metabolites were repored after intragastric administration of total flavonoids extract from PV in rats. ...

show abstract

Section: Phytochemistrymentioning

confidence: 99%

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

Gong

Zou

Zheng

et al. 2021

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

“…Targeting TNF-α inhibition by molecules or siRNA also attenuates the noise-induced cochlear inflammation and thus hearing threshold shift [92][93][94]. It is reported that noiseinduced increase of TNF-α can be regulated by nuclear factor of activated T cells 4 (Nfatc4), a well-researched transcription factor served as proinflammatory cytokine inducer.…”

Section: Inflammationmentioning

confidence: 99%

“…It is well testified that nuclear factor kappa B (NF- κ B) and its target proinflammatory genes play the central roles in inflammation regulation. Previous researches [ 94 , 106 , 107 ] have found that NF- κ B signaling cascade can be activated by noise trauma and inhibition of NF- κ B can decrease the content of proinflammatory cytokines. Glucocorticoid is the most commonly used medication for the treatment of NIHL, and its pharmaceutical activity is reported to be partly mediated by NF- κ B inhibition [ 108 ].…”

Section: Molecular Pathogenesismentioning

confidence: 99%

“…The circadian sensitivity alteration of the cochlea is proved to be adrenal gland-derived endogenous glucocorticoid dependent for its key role on inflammation regulation [ 110 ]. Besides, proinflammatory meditators like cyclooxygenase-2 (COX2) and NADPH oxidase 3 (NOX3) are also found upregulated after noise exposure, verifying the indispensable role of inflammation in the pathogenesis of NIHL [ 94 ].…”

Section: Molecular Pathogenesismentioning

confidence: 99%

See 1 more Smart Citation

Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions

Mao

Chen

2021

Neural Plasticity

View full text Add to dashboard Cite

Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve deterioration, resulting in transient or permanent hearing loss depending on the exposure severity. Oxidative stress, inflammation, calcium overload, glutamate excitotoxicity, and energy metabolism disturbance are the main contributors to noise-induced hearing loss (NIHL) up to now. Gene variations are also identified as NIHL related. Glucocorticoid is the only approved medication for NIHL treatment. New pharmaceuticals targeting oxidative stress, inflammation, or noise-induced neuropathy are emerging, highlighted by the nanoparticle-based drug delivery system. Given the complexity of the pathogenesis behind NIHL, deeper and more comprehensive studies still need to be fulfilled.

show abstract

“…We have previously reported that in animal models of exogenous insults as noise exposure or ototoxic drugs, it is possible to attenuate hearing loss and cochlear damage by targeting the endogenous antioxidant system, [ 10 , 12 , 13 , 14 ]. Indeed, we obtained significant ROS reduction and hearing loss amelioration by using antioxidants such as polyphenols and CoQ10 analogues [ 12 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation

et al. 2021

Self Cite

View full text Add to dashboard Cite

The cross-talk between oxidative stress and inflammation seems to play a key role in noise-induced hearing loss. Several studies have addressed the role of PPAR receptors in mediating antioxidant and anti-inflammatory effects and, although its protective activity has been demonstrated in several tissues, less is known about how PPARs could be involved in cochlear dysfunction induced by noise exposure. In this study, we used an in vivo model of noise-induced hearing loss to investigate how oxidative stress and inflammation participate in cochlear dysfunction through PPAR signaling pathways. Specifically, we found a progressive decrease in PPAR expression in the cochlea after acoustic trauma, paralleled by an increase in oxidative stress and inflammation. By comparing an antioxidant (Q-ter) and an anti-inflammatory (Anakinra) treatment, we demonstrated that oxidative stress is the primary element of damage in noise-induced cochlear injury and that increased inflammation can be considered a consequence of PPAR down-regulation induced by ROS production. Indeed, by decreasing oxidative stress, PPARs returned to control values, reactivating the negative control on inflammation in a feedback loop.

show abstract

Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss

Cited by 53 publications

References 46 publications

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions

Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation

Contact Info

Product

Resources

About