Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice

Kang, Ji Hee; Yun, Sung Il; Park, Mi Hee; Park, Junhong; Jeong, So Young; Park, Han Oh

doi:10.1371/journal.pone.0054617

Cited by 182 publications

(118 citation statements)

References 41 publications

(43 reference statements)

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“…As mentioned before [141][142][143][144], probiotic bacteria improve intestinal barrier integrity, thereby decreasing LPS translocation to the periphery and leading to reduced production of pro-inflammatory cytokines in adipose tissue. Similarly, it has been recently established that L. rhamnosus GG (LGG) displays anti-obesity and antidiabetic effects when administered to high-fat diet-fed mice [147,148]. Oral administration with LGG for 13 weeks notably led to increased expression of fatty acid oxidation genes in the liver and decreased expression of gluconeogenic genes.…”

Section: Probioticsmentioning

confidence: 99%

“…LGG treatment also increased glucose transporter-4 gene expression in skeletal muscle and adiponectin production in adipose tissue [147,148]. In a clinical setting, B. infantis 35624 was orally administrated for 6 to 8 weeks to patients with gastrointestinal (ulcerative colitis) or non-gastrointestinal (chronic fatigue syndrome, psoriasis) disorders [149].…”

Section: Probioticsmentioning

confidence: 99%

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Gut Microbiome-Brain Communications Regulate Host Physiology and Behavior

Lee¹,

Serre²

2015

JNHFS

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cell injury [6], metabolic regulation [7], GI tract development [8], innate and adaptive immune responses, and absorption of nutrients [9,10]. Alterations in microbiota composition and dysregulation of the intestinal mucosa homeostasis have been implicated in the development and progression of pathologies. This compositional change in the microbiota and/ or an abnormality in the interactions between the host and the commensal microbiota is referred to as dysbiosis. Gut microbiota dysbiosis has been linked to chronic low-grade intestinal inflammation and acute intestinal autoimmunity diseases such as Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) [11,12]. Abnormal microbiota composition is associated with a wide range of metabolic and behavioral disorders, such as anxiety/depression [13][14][15] [26]. GI microbiota dysbiosis might also be involved in the development and persistence of systemic disorders [27]. For example, obesity has been characterized by a decrease in overall diversity [28] and an increase in Proteobacteria abundance and in the Firmicutes to Bacteroidetes ratio [28,29] and microbiota composition is believed to influence energy balance and glucose homeostasis [30][31][32].Evidence that changes in microbiota composition are correlated with metabolic and behavioral disorders has drawn attention to a potential causal role for the microbiota in pathologies and has led to the emergence of the 'microbiota-gutbrain axis' concept [33][34][35]. The gut-brain axis is a bidirectional communication system between the GI tract and the brain [36] via hormonal, immunological, and neural signaling. Information from the GI tract and the intestinal microbiota can reach the peripheral and Central Nervous System (CNS), concurrently the brain is able to influence GI functions such as motility and secretion but also immune responses and cytokine production [36,37]. The Microbiota-Gut-Brain AxisThe gut microbiota can modulate gut-brain axis signaling via direct and indirect mechanisms. The microbiota acts via endocrine, metabolic (bacterial components and metabolites), AbstractThe human gut microbiota contains more than 100 trillion bacteria that, under normal physiological conditions, have beneficial symbiotic interactions with the host. However, a growing body of evidence has shown that alternations in the composition and diversity of the gut microbiota, or dysbiosis, can influence the development and progress of metabolic and neurological disorders. Communication between the microbiota and the brain is a bidirectional system involving endocrine, metabolic (bacterial components and metabolites), immune, and neural pathways. Gut microbiota composition influences the signals transmitted from the gut to the brain. Alternatively, the brain utilizes similar mechanisms, in particular endocrine and neural signaling, to modulate the composition of the gut bacteria. In this review, we describe the recent evidence of gut microbiota interaction with the central nervous system to influence physiological a...

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Section: Probioticsmentioning

confidence: 99%

Section: Probioticsmentioning

confidence: 99%

Gut Microbiome-Brain Communications Regulate Host Physiology and Behavior

Lee¹,

Serre²

2015

JNHFS

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“…Lactobacillus gasseri BNR17 feeding showed a fat mass gain but body weight suppression in obese rodents following a high-sucrose diet (Yun et al 2009;Kang et al 2010Kang et al , 2013Druart et al 2014). Some other studies have focused on the use of Bifidobacterium strains to evaluate the effects of probiotics and their potential antiobesity effect (Druart et al 2014).…”

Section: Probioticsmentioning

confidence: 99%

The art of targeting gut microbiota for tackling human obesity

Aguirre

Venema

2015

Genes Nutr

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Recently, a great deal of interest has been expressed regarding strategies to tackle worldwide obesity because of its accelerated wide spread accompanied with numerous negative effects on health and high costs. Obesity has been traditionally associated with an imbalance in energy consumed when compared to energy expenditure. However, growing evidence suggests a less simplistic event in which gut microbiota plays a key role. Obesity, in terms of microbiota, is a complicated disequilibrium that presents many unclear complications. Despite this, there is special interest in characterizing compositionally and functionally the obese gut microbiota with the help of in vitro, animal and human studies. Considering the gut microbiota as a factor contributing to human obesity represents a tool of great therapeutic potential. This paper reviews the use of antimicrobials, probiotics, fecal microbial therapy, prebiotics and diet to manipulate obesity through the human gut microbiota and reveals inconsistencies and implications for future study.

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“…isolated from Cheonggukjang; 10) Enterococcus faecium isolated from Cheonggukjang; 11) Pediococcus acidilactici isolated from Cheonggukjang. Lactobacillus curvatus isolated from Kimchi; 2) Weissella viridescens isolated from Kimchi; 3) Lactobacillus plantarum isolated from Kimchi; 4) Leuconostoc lactis isolated from Kimchi; 5) Lactobacillus acidophilus isolated from Kimchi; 6) Lactobacillus sakei subsp.…”

Section: )mentioning

confidence: 99%

“…isolated from Cheonggukjang; 10) Enterococcus faecium isolated from Cheonggukjang; 11) Pediococcus acidilactici isolated from Cheonggukjang. …”

Section: )mentioning

confidence: 99%

Antibacterial activity of lactic acid bacteria isolated from traditional fermented foods and development of a starter for fermented milk

Park¹,

Moon²,

Oh³

et al. 2013

Korean Journal of Food Preservation

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This study was conducted to investigate the antibacterial activity of lactic acid bacteria isolated from traditional fermented foods and to develop a new starter for fermented milk. The isolates were identified using 16S rDNA sequencing and named Lactobacillus plantarum A, Leuconostoc lactis B and L. acidophilus C. The activity of these strains to inhibit the growth of food-borne human pathogens (Escherichia coli NCTC 12923, Salmonella Typhimurium NCTC 12023, Listeria monocytogenes NCTC 11994) was measured using the paper disc method. All these strains showed strong antibacterial activity against Li. monocytogenes NCTC 11994. The experiment groups were the fermented milks with these strains, and the control group was the fermented milk with the commercial starter (ABT 5). The change of pH, acidity and viable cell counts were measured during their aging time. All the experiment groups showed a significant difference in their aging times compared to the control group. However, the sensory test showed that the experiment groups can be used as useful starters for fermented milk. This result suggests that L. plantarum A, Leu. lactis B and L. acidophilus C have the potential to be developed as new starters for fermented milk.

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Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice

Cited by 182 publications

References 41 publications

Gut Microbiome-Brain Communications Regulate Host Physiology and Behavior

Gut Microbiome-Brain Communications Regulate Host Physiology and Behavior

The art of targeting gut microbiota for tackling human obesity

Antibacterial activity of lactic acid bacteria isolated from traditional fermented foods and development of a starter for fermented milk

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