Anti-obesity and hypoglycemic effect of ethanolic extract of Murraya koenigii (L) leaves in high fatty diet rats

Tembhurne, S. V.; Sakarkar, D. M.

doi:10.1016/s2222-1808(12)60145-5

Cited by 28 publications

(17 citation statements)

References 9 publications

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“…It has also been shown that Murrya koenigii exerts insulin sensitizing and antioxidant activities, besides its α-glucosimidase inhibitory activity that can aid in glycemic control. 76 , 77 Ocimun tenuiflorum leaves are traditionally used in diabetes in Malaysia. Investigation on the hypoglycemic effects of O. tenuiflorum extract revealed preventing of hepatic gluconeogenesis as well as activation of glucose uptake in adipose tissues and skeletal muscle.…”

Section: Herbal Remedy In Diabetesmentioning

confidence: 99%

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Choudhury

Pandey

Hua

et al. 2018

Journal of Traditional and Complementary Medicine

345

192

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Herbal medicine, phytomedicine or botanical medicine are synonymous, utilizes plants intended for medicinal purposes. Medicinal use of herbal medicine in the treatment and prevention of diseases including diabetes has a long history compared to conventional medicine. Diabetes is one of the major public health concerns over the world. Diabetes or hyperglycemia is considered to be one of the common public health hazard; optimal control of which is still not possible. Persistent hyperglycemia or uncontrolled diabetes has the potential to cause serious complications such as kidney disease, vision loss, cardiovascular disease, and lower-limb amputations which contributed towards morbidity and mortality in diabetes. There are various approaches to treat and prevent diabetes as well as its secondary complications, one of it is herbal medicines. However, the selection of herbs might depends on several factors, which include the stage of progression of diabetes, types of comorbidities that the patients are having, availability, affordability as well as the safety profile of the herbs. This review focuses on the herbal and natural remedies that play the role in the treatment or prevention of this morbid disorder – diabetes, including their underlying mechanisms for the blood glucose-lowering property and the herbal products already been marketed for the remedial action of diabetes.

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Section: Herbal Remedy In Diabetesmentioning

confidence: 99%

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Choudhury

Pandey

Hua

et al. 2018

Journal of Traditional and Complementary Medicine

345

192

View full text Add to dashboard Cite

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“…The liver is the vital part of our body which is responsible for detoxification of toxic metabolites, protein synthesis and productions of compounds required for food digestion [18]. Excessive free radicals are known to cause liver damage and may result in hepatitis, cirrhosis and hepatic tumor [19].…”

Section: Introductionmentioning

confidence: 99%

Association of long-term consumption of repeatedly heated mix vegetable oils in different doses and hepatic toxicity through fat accumulation

2020

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Background: Hepatic diseases are one of the chief reasons for worldwide morbidity and mortality. The increased incidence in Asian countries is driving researchers to explore preventive ways from nature. It is more practical to go with healthy routine edibles like vegetable oils to avoid environmental and chemical hepatic injuries. With the use of thermally oxidized oils overproduction of reactive oxygen species (ROS) with overwhelmed cellular antioxidants defense system results in oxidative stress, the known cause of cardiovascular diseases (CVDs), cancers and neurodegenerative disorders. Little is investigated about the effect of daily used oxidized cooking oils on hepatic function changes with oxidative stress especially in the animal model that mimics the human situation. Methods: In this study, healthy adult male rabbits of local strain were divided into 4 groups (n = 12). First, two sets of rabbits were treated with 1 and 2 ml/kg/day of repeatedly heated mix vegetable oils (RHMVO) respectively. The third set of rabbits was given 1 ml/kg/day of single time heated mix vegetable oils (STHMVO) and the fourth set of rabbits served as controls and fed with normal rabbit diet to for 16 weeks. Serum liver function markers including total-protein, albumin, serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT) and alkaline phosphatase (ALP) along with the activity of hepatic antioxidant-enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and malondialdehyde (MDA) for lipid peroxidation were compared among different groups of rabbits. Histopathological examination was performed for all four groups. Results: Significantly (p < 0.05) elevated hepatic enzymes and MDA levels, with lower total protein, serum albumin, GPx, SOD and CAT levels were found in high and low doses RHMVO treated groups, in comparison to control. In the STHMVO group, all mentioned markers were insignificantly changed. Accumulation of liver fat in low and high dose oil-treated groups was further confirmed under the microscopic examination of liver tissues, presented significant fat accumulation in liver tissues, in addition, 40-60% increased oxidative stress compared to control, in a dose-dependent manner. Conclusions: These results conclude that consumption of thermally oxidized mix vegetable oils for longer duration can impair the liver function and destroy its histological structure significantly through fat accumulation and oxidative stress both in high as well as low doses.

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“…The lipid-lowering activity of MK LE is reported in several animal studies, in the different doses, in the range of 80-600 mg [20,21,23]. To our knowledge, this is the first animal study that evaluated the effect of MK LE, in RHMVO-induced hypercholesterolemia in animals, also using the standard (lovastatin).…”

Section: Discussionmentioning

confidence: 91%

“…With the vast range of biological activities such as antidyslipidemic [ 20 – 22 ], platelet aggregation inhibiting [ 23 ], antioxidant [ 24 ], and hypoglycemic activities [ 25 ], it gained the attention of researchers worldwide. Several animal studies have reported this spice as a potent antidyslipidemic agent and the response was achieved in 4–8 weeks, in a dose-dependent manner [ 20 , 21 ]. A recent human study, conducted on 45–65 years women of postmenopausal phase with hyperlipidemia, also reported that M. koenigii leaves intake for 45 consecutive days can significantly reduce the blood lipid levels [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Repeatedly heated mix vegetable oils-induced atherosclerosis and effects of Murraya koenigii

Gul

Siddiq

Hussain

et al. 2020

BMC Complement Med Ther

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Background: Statins are considered as standard drugs to control cholesterol levels, but their use is also associated with renal hypertrophy, hemorrhagic stroke, hepatomegaly, and myopathy. Murraya koenigii is an herb that is used in traditional cuisine and as a medicine in South Asia. Here we assessed the antidyslipidemic and antiatherosclerotic effects of this spice in repeated heated mix vegetable oils (RHMVO)-induced atherosclerotic models. Methods: Aqueous extract of M. koenigii leaves (Mk LE) was prepared and its phytoconstituents were determined. Rabbits were divided into 5 groups (n = 10). Except for the control group, all the other four groups were treated with RHMVO for 16 weeks (dose = 2 ml/kg/day) to induce dyslipidemia and atherosclerosis. These groups were further treated for 10 weeks either with 300 and 500 mg/kg/day Mk LE, lovastatin, RHMVO, or left untreated. Body and organ weights were measured along with oxidative stress and tissue damage parameters. Lipid profile and hepatic function markers were studied. Atheroma measurement and histopathological examination were also performed in control and treated groups. Results: Mk LE significantly (p < 0.05) attenuated RHMVO-induced dyslipidemia and atheroma formation. Furthermore, fat accumulation and lipid peroxidation in hepatic tissues were reduced by Mk LE in a dosedependent manner. Our results indicated that the antidyslipidemic effects of Mk LE in 500 mg/kg/day dose were comparable to lovastatin. Additionally, oxidative stress markers were reduced much more significantly in Mk LE-500 than in the statin group (p < 0.05). Conclusions: This study recommends Mk LE as a potent antioxidant and lipid-lowering natural medicine that can attenuate the RHMVO-induced atherosclerotic in optimal doses and duration. Therefore, Mk LE can be accessible, cheap, and free of adverse effects alternate to statins.

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Anti-obesity and hypoglycemic effect of ethanolic extract of Murraya koenigii (L) leaves in high fatty diet rats

Cited by 28 publications

References 9 publications

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Association of long-term consumption of repeatedly heated mix vegetable oils in different doses and hepatic toxicity through fat accumulation

Repeatedly heated mix vegetable oils-induced atherosclerosis and effects of Murraya koenigii

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