Anti-Obesity and Antihyperglycemic Effects of &amp;lt;i&amp;gt;Crataegus aronia&amp;lt;/i&amp;gt; Extracts: &amp;lt;i&amp;gt;In  Vitro&amp;lt;/i&amp;gt; and &amp;lt;i&amp;gt;in Vivo&amp;lt;/i&amp;gt; Evaluations

Al-Hallaq, Entisar K; Kasabri, Violet; Abdalla, Shtaywy; Bustanji, Yasser; Afifi, Fatma U.

doi:10.4236/fns.2013.49126

Cited by 16 publications

(16 citation statements)

References 58 publications

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“…The orlistat PL-IC 50 value obtained in this current study is comparable to the other reported PL-IC 50 values [20]. These significant anti-lipase effects of sage may be solidly related to the effect of the major compounds identified in the crude extract [8,20] acting additively or synergistically in optimal ratio [22]. Hydrocarbons, sterols, triterpenes, fatty acids, phenolic acids, and flavonoids have been identified in S. triloba.…”

Section: Discussionsupporting

confidence: 77%

“…Enzyme assay was conducted by the spectrophotometric method as per the protocol from Al-Hallaq et al [8][9] and Bustanji et al [15]. Subsequent determinations were undertaken for the tested extracts and orlistat (n = 3) to calculate the concentration required for the PL 50 % inhibition (IC 50 ).…”

Section: Spectrophotometric Quantification Of Pl Inhibition By Test Ementioning

confidence: 99%

“…The success of tetrahydrolipstatin (orlistat) which is a specific pancreatic lipase inhibitor has prompted research to identify new pancreatic lipase inhibitors derived from natural sources [7][8][9]. Natural compounds, like berberine, dihydroberberine and curcumin have substantially been proven as PLinhibitors [10][11].…”

Section: Introductionmentioning

confidence: 99%

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Antilipolytic and hypotriglyceridemic effects of dietary <i>Salvia triloba</i> Lf (Lamiaceae) in experimental rats

Arabiyat¹,

Al-Rabi'ee²,

Zalloum³

et al. 2016

Trop. J. Pharm Res

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Purpose: Pancreatic triacylglycerol lipase (PL) is a noteworthy pharmacological target for the management of dyslipidemia, and diabetes and obesity. This study was aimed to evaluate the modulatory effects of Salvia triloba L.f. (Lamiaceae) leaves methanol extract (ME) on a high fat diet (HFD)-induced hypertriglyceridemia in rats, with complementary in vitro evaluation of sage PL-inhibitory potential. Methods: Pre-induction of HFD hypertriglyceridemia sage leaves ME (750 mg/kg) was orally supplemented (via gastric intubation) to overnight fasting rats (n = 5). Potential plant modulation of PL was also quantified in vitro by a colorimetric assay (n = 3

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Section: Discussionsupporting

confidence: 77%

Section: Spectrophotometric Quantification Of Pl Inhibition By Test Ementioning

confidence: 99%

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Antilipolytic and hypotriglyceridemic effects of dietary <i>Salvia triloba</i> Lf (Lamiaceae) in experimental rats

Arabiyat¹,

Al-Rabi'ee²,

Zalloum³

et al. 2016

Trop. J. Pharm Res

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“…These significant anti-lipase effects may be solidly related to the effect of the major compounds identified in the crude extract (Habtemariam 2012;Al-Hallaq et al 2013). Caffeic acid and chlorogenic acid contributed to the PL and a-amylase inhibitory potential of Clematis vitalba L. (Ranunculaceae) and Echium vulgare L. (Boraginaceae) extracts (Marrelli et al 2013(Marrelli et al , 2014.…”

Section: Results Discussion and Future Directivesmentioning

confidence: 99%

Antiobesity and antihyperglycaemic effects of Adiantum capillus-veneris extracts: in vitro and in vivo evaluations

Kasabri

Al-Hallaq²,

Bustanji

et al. 2016

Pharmaceutical Biology

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Context: Adiantum capillus-veneris L. (Adiantaceae) hypocholesterolemic activity is therapeutically praised. Objectives: Pharmacological modulation of pancreatic triacylglycerol lipase (PL) and a-amylase/a-glucosidase by A. capillus-veneris are evaluated. Materials and methods: Using positive controls (acarbose, orlistat, guar gum, atorvastatin, glipizide and metformin) as appropriate, crude aqueous extracts (AEs) of A. capillus-veneris aerial parts were tested via a combination of in vitro enzymatic (0.24-100 mg/mL), acute in vivo carbohydrate tolerance tests (125, 250 or 500 mg/kg body weight [b.wt]) and chronic in vivo studies (500 mg/kg b.wt) in high cholesterol diet (HCD) fed Wistar rats. Results: Like acarbose, A. capillus-veneris as well as chlorogenic acid, with respective IC 50 values (mg/mL) of 0.8 ± 0.0 and 0.2 ± 0.0, were identified as in vitro potent dual inhibitors of a-amylase/a-glucosidase. Unlike guar gum, A. capillus-veneris had no glucose diffusion hindrance capacity. Equivalent to orlistat, A. capillus-veneris and its phytoconstituents inhibited PL in vitro with an ascending order of PL-IC 50 values (lg/mL): ferulic acid; 0.48 ± 0.06 < ellagic acid; 13.53 ± 1.83 < chlorogenic acid; 38.4 ± 2.8 < A. capillus-veneris; 1600 ± 100. Incomparable to acarbose or metformin and glipizide, A. capillus-veneris (125, 250 and 500 mg/kg b.wt) lacked antihyperglycaemic efficacies in acute starch-or glucose-evoked postprandial hyperglycaemia increments in normoglycaemic overnight fasting rats. Superior to atorvastatin; A. capillusveneris exerted significant antiobesity (p < 0.001) with marked triacylglycerol-reducing capacities (p < 0.001) in comparison to rats fed with HCD for 10 weeks. Discussion and conclusion: A. capillus-veneris, modulating pancreatic digestive enzymes, may be advocated as a combinatorial diabesity prevention/phytotherapy agent. ARTICLE HISTORY

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“…aronia L. (hawthorn), from the family of Rosaceae is native to Mediterranean region, Asia, Europe, Africa and North America (Figure ) . More than 280 species of the genus hawthorn have been described and some literatures showed that hawthorn species includes 150 to 1200 species . In fact, they are native to Northern temperate zones, mostly between latitudes 30° and 50° N and comprises of a complex group of trees and shrubs.…”

Section: Introductionmentioning

confidence: 99%

In situ green synthesis of Cu‐Ni bimetallic nanoparticles supported on reduced graphene oxide as an effective and recyclable catalyst for the synthesis of N‐benzyl‐N‐aryl‐5‐amino‐1H‐tetrazoles

Nasrollahzadeh

Sajjadi

Komber

et al. 2019

Applied Organom Chemis

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In the present work, for the first time we have designed a novel approach for the synthesis of N‐benzyl‐N‐aryl‐5‐amino‐1H‐tetrazoles using reduced graphene oxide (rGO) decorated with Cu‐Ni bimetallic nanoparticles (NPs). In situ synthesis of Cu/Ni/rGO nanocomposite was performed by a cost efficient, surfactant‐free and environmentally benign method using Crataegus azarolus var. aronia L. leaf extract as a stabilizing and reducing agent. Phytochemicals present in the extract can be used to reduce Cu2+ and Ni2+ ions and GO to Cu NPs, Ni NPs and rGO, respectively. Analyses by means of FT‐IR, UV–Vis, EDS, TEM, FESEM, XRD and elemental mapping confirmed the Cu/Ni/rGO formation and also FT‐IR, NMR, and mass spectroscopy as well as elemental analysis were used to characterize the tetrazoles. The Cu/Ni/rGO nanocomposite showed the superior catalytic activity for the synthesis of N‐benzyl‐N‐aryl‐5‐amino‐1H‐tetrazoles within a short reaction time and high yields. Furthermore, this protocol eliminates the need to handle HN3.

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Anti-Obesity and Antihyperglycemic Effects of <i>Crataegus aronia</i> Extracts: <i>In Vitro</i> and <i>in Vivo</i> Evaluations

Cited by 16 publications

References 58 publications

Antilipolytic and hypotriglyceridemic effects of dietary <i>Salvia triloba</i> Lf (Lamiaceae) in experimental rats

Antilipolytic and hypotriglyceridemic effects of dietary <i>Salvia triloba</i> Lf (Lamiaceae) in experimental rats

Antiobesity and antihyperglycaemic effects of Adiantum capillus-veneris extracts: in vitro and in vivo evaluations

In situ green synthesis of Cu‐Ni bimetallic nanoparticles supported on reduced graphene oxide as an effective and recyclable catalyst for the synthesis of N‐benzyl‐N‐aryl‐5‐amino‐1H‐tetrazoles

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