Anti-nociceptive and anti-oedematogenic properties of the hydroethanolic extract of Sidastrum micranthum leaves in mice

Gonçalves, Gabriela Mastrangelo; Marinho, Diogo Guimarães; Almança, Carlos Cesar Jorden; Marinho, Bruno Guimarães

doi:10.1590/s0102-695x2013000500017

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…The tail immersion induced pain model is executed to examine the acute pain and it is a helpful assay to differentiate the central opioid like analgesics from peripheral analgesics [43]. The open field test was performed to confirm the anti-nociceptive action of sample analgesic agents related to non-specific disturbances in the locomotor activity of the experimental animals [47].…”

Section: Discussionmentioning

confidence: 99%

Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model

Liu

Kang

Liu³

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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In this study, we synthesised the zinc oxide nanoparticles from Vernonia amygdalina and evaluated its anti-inflammatory and antinociceptive potentials against the different inflammation and pain induced mice model. The synthesised zinc oxide nanoparticles were characterised by UV, SEM, XRD and FTIR techniques. The anti-nociceptive effects of V. amygdalina were examined by different stimuli e.g. acetic acid, glutamate, capsaicin, and formalin-induced nociception in mice. The anti-inflammatory effects of synthesised zinc oxide nanoparticles were assessed by air sack assessment and the level of inflammatory cytokines were studied. The muscle tension of animals were studied through open field assessment. The present study exhibited proficient antinociceptive and anti-inflammatory actions of the synthesised Zinc oxide nanoparticles from V. amygdalina. The sormulated zinc oxide nanoparticles were appreciably reduced the acetic acid, glutamate, capsaicin, and formalin-induced nociceptive responses in mice. Further the zinc nanoparticles were exhibited the potent anti-inflammatory actions via reducing the inflammatory response and pro-inflammatory cytokines level in the mice. In conclusion, the findings of this study proved the beneficial effects of zinc oxide nanoparticles from V. amygdalina against the different pain and inflammation-induced mice. Hence, it was clear that the zinc nanoparticles from V. amygdalina could be promising antinociceptive and anti-inflammatory agent in the future.

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Section: Discussionmentioning

confidence: 99%

Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model

Liu

Kang

Liu³

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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show abstract

“…The open field test was used to exclude the possibility that the anti-nociceptive action of extract could be related to nonspecific disturbances in the locomotor activity of the animals (Gonç alves et al, 2013). The extract at all doses tested caused no significant change in the locomotor coordination activity of the animals.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and antiulcer activities of Pycnanthus angolensis

Sofidiya

Awolesi

2015

Revista Brasileira de Farmacognosia

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a b s t r a c tPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.

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“…Our results are in line with the later stage as DAG inhibited the pain at the peripheral level. 18 It has been shown that drugs such as morphine inhibited both acute and chronic phase of formalin induced pain while aspirin or hydrocortisone which are peripherally acting only inhibits the late phase of pain. 19,20 As shown in Fig.…”

Section: Fig 4: Anti-inflammatory Effect Of Different Doses Of Doremmentioning

confidence: 99%

Untitled

2017

IJPSR

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Dorema ammoniacum gum (DAG) has been used for different illnesses in Iranian traditional medicine. The main objective of the present study was to evaluate the analgesic and anti-inflammatory activities of aqueous solution of Dorema ammoniacum gum (DAG) in animal model. The anti-inflammatory and analgesic Effects of DAG were examined using carraginane-induced edema test, formalin test and acetic acid-induced writhing response. 42 male albino mice randomly assigned in different groups were pretreated randomly assigned 5 groups. Groups were pretreated either with normal saline, morphine or aspirin and different doses of DAG (125, 250, 500 mg/kg, i.p.) for determination of analgesic effect. The anti-inflammatory effect was evaluated by the rat paw carrageenan induced edema and was compared to positive controls. DAG exhibited the analgesic effect in chronic phase of formalin test in a dose-dependent manner (P<0.05). Also, application of different doses of DAG had significant analgesic effect in acetic acid writing test 30 min after its injection. DAG showed anti-inflammatory effect in a dose dependent manner. The anti-inflammatory effect of the extract was comparable to indomethacin in higher doses. Thus, our results demonstrate that ammoniacum gum has anti-inflammatory and analgesic effects in animal models and hence justify the traditional use of this plant in the treatment of pain and inflammatory conditions. Further studies seem necessary to clarify about the active components of this plant.

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Anti-nociceptive and anti-oedematogenic properties of the hydroethanolic extract of Sidastrum micranthum leaves in mice

Cited by 3 publications

References 32 publications

Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model

Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model

Antinociceptive and antiulcer activities of Pycnanthus angolensis

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