Anti-Inflammatory Properties of Pavetta Crassicaulis Bremek. Leaf and Flower Crude Extracts and Its Pure Compounds Collected From Western Ghats, Karnataka, India

Ashwathanarayana, R; Naika, Raja

doi:10.22159/ajpcr.2018.v11i9.21885

Cited by 8 publications

(2 citation statements)

References 12 publications

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“…Hence, these results are representative of the potential of consumed vegetables to inhibit NO. A review of earlier studies showed similar antiinflammatory potentials of medicinal plants [23,24]. Likewise, turmeric from Curcuma longa has been shown to have interesting anti-inflammatory activity [25].…”

Section: Discussionmentioning

confidence: 95%

Antioxidant and Inhibitory Effect of Selected Ghanaian Vegetables on Nitric Oxide Expression in Lipopolysaccharide-Induced Macrophage Cells

OFORI-ATTAH,

ANING,

GORDON

et al. 2023

Int J Pharm Pharm Sci

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Objective: Nitric oxide (NO) is a signaling molecule that plays a key role in the pathogenesis of inflammation. Inhibitors of NO may be useful candidates for the treatment of inflammatory diseases. The study aimed to determine the antioxidant and inhibitory effect of commonly used Ghanaian vegetables, namely Corchorus olitorius (CO), Solanum melongena (SM), Solanum torvum (ST), Xanthosoma sagittifolia (XS) and Abelmoschus esculentus (AE) on NO expression in a Lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cell line. Methods: The cytotoxic effects of the vegetables on the cell line were determined using a tetrazolium-based colorimetric assay. The inflammatory activity was determined by measuring the inhibition of NO production in LPS-induced RAW 264.7 macrophage cells. Total antioxidant activity, total phenolic, flavonoid, and reduced glutathione contents were evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, Folin-Ciocalteu, aluminium chloride, and O-Phthalaldehyde methods, respectively. Results: Our results showed that CO and ST significantly inhibited NO production in a concentration-dependent manner with good cell viability. Solanum torvum also exhibited strong antioxidant activity (IC50= 0.466±0.23 mg/ml) with total phenolic content of 230.73±1.84 mg/g GAE, while CO showed high flavonoid content (291.45±2.14 mg/g QUE). Abelmoschus esculentus recorded the highest glutathione content (58.6 µg/g GSH. Saponins, alkaloids, tannins, terpenoids, and cardiac glycosides were present in all the samples except SM and AE, which lacked terpenoids. Conclusion: These findings suggest that CO and ST possess anti-inflammatory and antioxidant activities that could be explored as potential therapeutic remedies for inflammatory disorders.

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Section: Discussionmentioning

confidence: 95%

Antioxidant and Inhibitory Effect of Selected Ghanaian Vegetables on Nitric Oxide Expression in Lipopolysaccharide-Induced Macrophage Cells

OFORI-ATTAH,

ANING,

GORDON

et al. 2023

Int J Pharm Pharm Sci

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“…The ethanol extract of P. crassicaulis flowers showed an appreciable reduction in edema in all the phases and all the intervals, but the leaves extract outperformed the floral extract. However, both are more powerful than diclofenac [36].…”

Section: H Anti-inflammatorymentioning

confidence: 96%

Therapeutic Potential of Pavetta L. Genus: An Updated Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects

Al-Madhagy

El‐Hawary²,

Sabry³

et al. 2022

Egypt. J. Chem.

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Pavetta L. genus is one of the largest genera in Rubiaceae family. Although of the wide distribution and the variety of traditional uses of it plants, research covered only limited species of Pavetta L. genus. The purpose of this review is to provide an in-depth understanding of traditional uses, phytochemical, pharmacological, and toxicological characteristics of these plants, which may lead to new insights into new therapeutic benefits of them. To achieve that, literatures without time limitation was used to gather information about all features of Pavetta L. genus including its botanical description and geographical distribution.

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GC-MS fingerprinting and antibacterial activity of in vitro raised plant parts of Solanum khasianum Clarke

Chirumamilla,

Dharavath,

Koduri

et al. 2023

Vegetos

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Anti-Inflammatory Properties of Pavetta Crassicaulis Bremek. Leaf and Flower Crude Extracts and Its Pure Compounds Collected From Western Ghats, Karnataka, India

Cited by 8 publications

References 12 publications

Antioxidant and Inhibitory Effect of Selected Ghanaian Vegetables on Nitric Oxide Expression in Lipopolysaccharide-Induced Macrophage Cells

Antioxidant and Inhibitory Effect of Selected Ghanaian Vegetables on Nitric Oxide Expression in Lipopolysaccharide-Induced Macrophage Cells

Therapeutic Potential of Pavetta L. Genus: An Updated Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects

GC-MS fingerprinting and antibacterial activity of in vitro raised plant parts of Solanum khasianum Clarke

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