Anti‐Inflammatory Effects of p‐Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats

Abstract

Objectives In China, Oldenlandia diffusa (OD) is a natural herb that is widely used and has been proven to be effective in the treatment of rheumatoid arthritis (RA). This study aimed to preliminarily reveal the mechanism by which OD exerts its beneficial effect. Methods Ultra-performance liquid chromatography photodiode array was applied to identify the absorbable compounds in the plasma of collagen-induced arthritis (CIA) model rats. After 2 weeks, an OD decoction or the identified absorbable compound was administered to CIA rats. Morphology, X-ray images of the joints, pathological images, arthritis index, and cytokine (TNF-α and IL-6) levels were evaluated. Results p-Coumaric acid (p-CA) was identified as the absorbed compound in plasma. After administration of p-CA solution or the OD decoction, symptoms in the treated rats were alleviated as compared to the untreated model rats, and inflammatory cell infiltration was suppressed. The arthritis index and serum levels of TNF-α and IL-6 were decreased as compared to the control group. Conclusions OD may exert its anti-inflammatory effect on RA via its active ingredient, p-CA. This information sheds light on the mechanism by which OD exerts its anti-inflammatory effort in RA and forms the basis for further development of therapeutic agents for RA.

Targeted Development-Dependent Metabolomics Profiling of Bioactive Compounds in Acanthopanax senticosus by UPLC-ESI-MS

“…41 The results of the determination of 19 phenolic metabolites showed growth year-specific properties, with the C 6 C 3 -type metabolites mainly accumulated in 3-year-old plants, the C 6 C 1 -type in 9-year-old plants, and the C 6 C 3 C 6 -type in 5-year-old plants. p-Coumaric acid is said to have antioxidant, 42 anti-inflammatory, 43 and neuroprotective effects. 44 The results showed that pcoumaric acid accumulated mainly in the 3-year-old plants.…”

Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats

“…MAPK activation leads to phosphorylation of CREB gene in RNA which results in decreased expression of BDNF [ 44 ]. Further, anti-inflammatory and analgesic effects of p-CA are quite remarkable in several diseases such as diabetes, gout and arthritis, while p-CA has various bioactivities [ 45 46 ]. Its anti-inflammatory and analgesic effects were not inferior to drug such as indomethacin [ 45 ].…”

Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites

“…In the in vivo study of intraperitoneal administration of ferulic acid in the Balb/c mice upregulation of antioxidant protection and suppression of inflammatory responses via the inhibition of TLR-4 induced activation of nuclear factor kappa B (NF-κB) was observed, which indicates the potential use of ferulic acid for protection against sepsis-induced acute kidney injury [ 171 ]. p -Coumaric acid, as one of the active ingredients in the Chinese natural herb Oldenlandia difusa , showed anti-inflammatory activity via the suppression of inflammatory cell infiltration as well as the levels of TNF-α and IL-6, which are known as pro-inflammatory factors that can activate the NF-κB signaling pathway, thereby increasing the inflammatory response and have an important role in the pathogenesis of rheumatoid arthritis [ 172 ]. Similarly, in another study p -coumaric acid exhibited considerable anti-inflammatory activity in vivo in arthritic rats via reduction of TNF-α expression in synovial tissue and circulating immune complexes in serum [ 173 ].…”