2011
DOI: 10.1016/j.jep.2010.04.047
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Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis

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Cited by 117 publications
(58 citation statements)
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“…Administration of B. sensitivum attenuated colitis as shown by reduction in macroscopic score as well as decreased wet weight of colon compared with colitis control animals. It is well known that splenic atrophy is associated with a high complication rate in colitis patients (Cho et al, 2011), in the same way, administration of B. sensitivum extract exposed protecting effect by decreased spleen weight in animals with colitis. Enhanced vascular permeability seems to be the rate limiting step in mucosal damage (Viera et al, 2000) and thus prevention of increase in vascular permeability of colon by B. sensitivum may play an active role in the protecting effect of colon.…”
Section: Discussionmentioning
confidence: 89%
“…Administration of B. sensitivum attenuated colitis as shown by reduction in macroscopic score as well as decreased wet weight of colon compared with colitis control animals. It is well known that splenic atrophy is associated with a high complication rate in colitis patients (Cho et al, 2011), in the same way, administration of B. sensitivum extract exposed protecting effect by decreased spleen weight in animals with colitis. Enhanced vascular permeability seems to be the rate limiting step in mucosal damage (Viera et al, 2000) and thus prevention of increase in vascular permeability of colon by B. sensitivum may play an active role in the protecting effect of colon.…”
Section: Discussionmentioning
confidence: 89%
“…Consequently, alternative therapeutic strategies, including plant-based traditional remedies are now being re-evaluated. Several studies have shown effectiveness of natural products, herbs, and dietary components against inflammatory colitis such as Patrinia (Cho et al, 2010), Mangifera (Má rquez et al, 2010), sterol guggulsterone (Cheon et al, 2006), apple procyanidins (Yoshioka et al, 2008), embelin (Kumar et al, 2011), punicic acid (Bassaganya-Riera et al, 2011, and a combination of dietary fish oil and curcumin (Jia et al, 2011). Chaga mushroom has also been effectively used in several medicinal preparations to treat a variety of inflammatory and digestive system diseases, without any toxicity and side effects Nakajima et al, 2007;Shashkina et al, 2006;Wasser and Weis, 1999).…”
Section: Discussionmentioning
confidence: 99%
“…The elevation in the colon weight and colon weight to length ratio was inhibited by HRS depicting its healing property. Spleen is an indispensible part of immune system and reticuloendothelial system which has been found to be atrophied in chronic colitis [22] . The reduction in the splenic enlargement by the HRS proved the ability of HRS to modulate the immune system.…”
Section: Discussionmentioning
confidence: 99%