Anti-inflammatory effects of Brazilian ginseng (Pfaffia paniculata) on TNBS-induced intestinal inflammation: Experimental evidence

Costa, Celso A. R. A.; Tanimoto, Alexandre; Quaglio, Ana Elisa Valencise; Almeida, Luiz Domingues de; Severi, Juliana Aparecida; Stasi, Luiz Cláudio Di

doi:10.1016/j.intimp.2015.07.002

Cited by 24 publications

(15 citation statements)

References 80 publications

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“…The results of the present study also showed a 14% increase in serum CRP concentration in MCAO animals compared with controls (p > 0.05), with a ginseng treatment CRP level decrease by 6.0% in MCAO + PGE group compared with the MCAO group (p > 0.05). Consistent with our results, data from a study by FACETS | 2019 | 4: 52-68 | DOI: 10.1139/facets-2018-0025 63 facetsjournal.com Costa et al (2015) on experimental rat models of trinitrobenzenesulfonic-acid-induced intestinal inflammation also showed a decrease in serum CRP levels in rats under Brazilian ginseng treatment. LDH is another indicator of cerebrovascular pathologies.…”

Section: Shamim and Khansupporting

confidence: 90%

Neuroprotective effect ofPanax ginsengextract against cerebral ischemia–reperfusion-injury-induced oxidative stress in middle cerebral artery occlusion models

Shamim

Khan

2019

FACETS

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The present study investigated the in vivo neuroprotective role of Panax ginseng extract (PGE) pretreatment against transient cerebral ischemia in a middle cerebral artery occlusion (MCAO) model. Rats were randomly divided as follows: group I, control; group II, sham-operated; group III, where animals were subjected to MCAO surgery; and group IV, where animals were orally administered 10 mL PGE per day (200 mg/kg of body weight per day) for 30 d followed by MCAO induction at day 31. Following 24 h of reperfusion, blood and tissue (brain, liver, and kidney) samples were collected for biochemical and histopathological examination. Biochemical testing included lipid profile, liver enzymes, kidney function tests, C-reactive protein (CRP), lactate dehydrogenase (LDH), glucose, and total protein estimation. Tissue antioxidants (catalase, superoxide dismutase, and glutathione) were assessed in brain, liver, and kidney tissues. MCAO-induced histopathological changes were also examined in the tissues. Pretreatment with PGE showed significant improvement in tissue antioxidant status in brain, liver and kidney tissues. PGE treatment maintains plasma lipid profile, liver enzymes, kidney function, and CRP, LDH, and glucose levels. Histologically, monocytes and macrophage infiltration were observed in the tissues of MCAO animals, whereas PGE treatment preserved tissue architecture and minimal monocyte infiltration. PGE supplementation showed a neuroprotective effect against ischemia–reperfusion injury by effectively increasing endogenous antioxidant enzyme activity.

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Section: Shamim and Khansupporting

confidence: 90%

Neuroprotective effect ofPanax ginsengextract against cerebral ischemia–reperfusion-injury-induced oxidative stress in middle cerebral artery occlusion models

Shamim

Khan

2019

FACETS

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“…The results obtained with P. paniculata are difficult to discuss, since the articles in the literature address only their anticancer and antitumor [27, 28], anti-inflammatory [29], and cell activity modulator [30] effects, among others. However, until the present moment, there is no research with this extract regarding its antimicrobial potential, which makes our study of great importance, while opening new perspectives for studies with promising results.…”

Section: Discussionmentioning

confidence: 99%

Klebsiella pneumoniae Planktonic and Biofilm Reduction by Different Plant Extracts: In Vitro Study

Ramos

Santos

Mello

et al. 2016

The Scientific World Journal

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This study evaluated the action of Pfaffia paniculata K., Juglans regia L., and Rosmarius officinalis L. extracts against planktonic form and biofilm of Klebsiella pneumoniae (ATCC 4352). Minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) values were determined for each extract by microdilution broth method, according to Clinical and Laboratory Standards Institute. Next, antimicrobial activity of the extracts on biofilm was analyzed. For this, standardized suspension at 107 UFC/mL of K. pneumoniae was distributed into 96-well microplates (n = 10) and after 48 h at 37°C and biofilm was subjected to treatment for 5 min with the extracts at a concentration of 200 mg/mL. ANOVA and Tukey tests (5%) were used to verify statistical significant reduction (p < 0.05) of planktonic form and biofilm. P paniculata K., R. officinalis L., and J. regia L. showed reductions in biomass of 55.6, 58.1, and 18.65% and cell viability reduction of 72.4, 65.1, and 31.5%, respectively. The reduction obtained with P. paniculata and R. officinalis extracts was similar to the reduction obtained with chlorhexidine digluconate 2%. In conclusion, all extracts have microbicidal action on the planktonic form but only P. paniculata K. and R. officinalis L. were effective against biofilm.

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“…Costa et al [35] dowiedli na modelu eksperymentalnym skuteczności podaży P. paniculata w redukcji stresu oksydacyjnego, stężenia cytokin prozapalnych (IL-1, IFN-g, TNF-a i IL-6), CRP oraz aktywności mieloperoksydazy u szczurów, u których wywołano zapalenie okręż-nicy kwasem trinitrobenzenosulfonowym (TNBS). Pfaffia paniculata wykazywał ponadto aktywność immunomodulacyjną.…”

Section: Alternatywne Diety Eliminacyjneunclassified

New Trends in the Dietary Treatment of Inflammatory Bowel Diseases

Włochal¹,

Grzymisławski²

2016

Piel. Zdr. Publ.

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Anti-inflammatory effects of Brazilian ginseng (Pfaffia paniculata) on TNBS-induced intestinal inflammation: Experimental evidence

Cited by 24 publications

References 80 publications

Neuroprotective effect ofPanax ginsengextract against cerebral ischemia–reperfusion-injury-induced oxidative stress in middle cerebral artery occlusion models

Neuroprotective effect ofPanax ginsengextract against cerebral ischemia–reperfusion-injury-induced oxidative stress in middle cerebral artery occlusion models

Klebsiella pneumoniae Planktonic and Biofilm Reduction by Different Plant Extracts: In Vitro Study

New Trends in the Dietary Treatment of Inflammatory Bowel Diseases

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