Anti-inflammatory effects of a major component of Acanthopanax senticosus Harms, isofraxidin.

Yamazaki, Tsuneyuki; Shimosaka, S; Sakurai, Masayuki; Tsukiyama, Takashi; Tokiwa, Takayoshi

doi:10.2198/sbk.48.55

Cited by 4 publications

(6 citation statements)

References 10 publications

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“…We conclude that the roots of 3-year-old plants have anti-infection and anti-tumor effects. 14,33 The content of eleutheroside E is higher in 5-year-old roots. Therefore, we conclude that the 5-year-old roots have anti-infection, anti-depressant, anti-fatigue, and antidiabetic effects.…”

Section: Discussionmentioning

confidence: 97%

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Targeted Development-Dependent Metabolomics Profiling of Bioactive Compounds in Acanthopanax senticosus by UPLC-ESI-MS

Wang

et al. 2020

Natural Product Communications

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An ultra-performance liquid chromatography-electrospray ionization-mass spectrometry targeted metabolomics strategy was applied to analyze protocatechuate, syringin, eleutheroside E, isofraxidin, hyperoside, kaempferol, and oleanolic acid, the active compounds in 3-year-old, 5-year-old, and 9-year-old Acanthopanax senticosus. Then, targeted metabolomics was conducted with 3 growth year plants to identify 19 phenolic metabolites related to the above-mentioned active compounds, including 9 C6C3C6-type, 6 C6C3-type, and 4 C6C1-type. Multivariate statistical analysis was applied to the bioactive metabolite data, and targeted metabolic profiling was used for marker compound classification and characterization. The results showed that 7 active compounds in the roots and stems in the 3 growth year plants differed. The principal component “Q” values showed that the total contents of 7 active compounds in 5-year-old roots and stems were higher than in other growth years. Results of targeted metabolomics profiling of 19 phenolic metabolites showed that the C6C1-type compounds accumulated in 9-year-old plants, the C6C3-type in 3-year-old plants, and the C6C3C6-type in 5-year-old plants. The stems had the greatest accumulations of the phenolic metabolites. C6C1 and C6C3-type metabolites are the most abundant in both roots and stems. In conclusion, the active compounds and pharmacological effects of A. senticosus in different growth years are different. The best harvest age for A. senticosus roots and stems was 5 years. The accumulation of 19 phenolic metabolites in different growth years also showed significant differences.

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Section: Discussionmentioning

confidence: 97%

“…[9][10][11] Eleutheroside E has antidepressant and anti-fatigue effects, 12,13 and isofraxidin has anti-tumor, antibacterial, and anti-inflammatory activities. 14,15 Rutin, hyperoside, and kaempferol are common flavonoids, mainly present in A. senticosus leaves. 16 They have anti-oxidant and anti-infective effects.…”

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confidence: 99%

Targeted Development-Dependent Metabolomics Profiling of Bioactive Compounds in Acanthopanax senticosus by UPLC-ESI-MS

Wang

et al. 2020

Natural Product Communications

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“…It has been shown that eleutheroside E possesses an antistress [ 11 ] and anti-fatigue effect [ 4 , 11 ]. Meanwhile, several studies have suggested that isofraxidin has antibacterial [ 12 ] and antiinflammatory effects [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Enrichment and Purification of Syringin, Eleutheroside E and Isofraxidin from Acanthopanax senticosus by Macroporous Resin

Yang

Wang

et al. 2012

IJMS

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In order to screen a suitable resin for the preparative simultaneous separation and purification of syringin, eleutheroside E and isofraxidin from Acanthopanax senticosus, the adsorption and desorption properties of 17 widely used commercial macroporous resins were evaluated. According to our results, HPD100C, which adsorbs by the molecular tiers model, was the best macroporous resin, offering higher adsorption and desorption capacities and higher adsorption speed for syringin, eleutheroside E and isofraxidin than other resins. Dynamic adsorption and desorption tests were carried out to optimize the process parameters. The optimal conditions were as follows: for adsorption, processing volume: 24 BV, flow rate: 2 BV/h; for desorption, ethanol–water solution: 60:40 (v/v), eluent volume: 4 BV, flow rate: 3 BV/h. Under the above conditions, the contents of syringin, eleutheroside E and isofraxidin increased 174-fold, 20-fold and 5-fold and their recoveries were 80.93%, 93.97% and 93.79%, respectively.

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“…Isofraxidin was reported to exhibit anti-fatigue, anti-stress, and immuno-accomondating effects (Sun et al, 2007). Further investigations indicated that isofraxidin has the ability of diminishing inflammation (Yamazaki et al, 2004) and anbiosis (Liu et al, 2004a). Meanwhile, several studies have suggested that isofraxidin has anti-bacterial (Liu et al, 2004b) and anti-tumor effect (Yamazaki and Tokiwa, 2010).…”

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confidence: 99%

Preparative enrichment and separation of isofraxidin from Acanthopanax senticosus with HPD100C macroporous resin

Yang¹,

Ge²,

Yang³

et al. 2012

J. Med. Plants Res.

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Isofraxidin is known as the major pharmacological component in Acanthopanax senticosus. In the present study, in order to screen a suitable resin for the preparative separation and purification of isofraxidin, the adsorption and desorption properties of 26 widely used commercial macroporous resins were evaluated. The preliminary research results indicated that HPD100C and HPD300 have better properties. By comparing static adsorption kinetics of HPD100C and HPD300, HPD100C was selected as the most suitable resin. Langmuir and Freundlich isotherms models were used to describe the interaction between solutes and resins at 25, 30, 35°C, respectively, and the equilibrium experimental data fit better to the Langmuir isotherms. Dynamic adsorption and desorption tests have been carried out to optimize the process parameters. The optimal conditions were as follows: For adsorption, the concentration of isofraxidin in sample solution: 0.0436 mg/ml, processing volume: 24 BV, flow rate: 2 BV/h, temperature: 25°C; for desorption, ethanol-water solution: 60:40 (v/v), eluent volume: 4 BV, flow rate: 3 BV/h. Under the conditions aforementioned, the content of isofraxidin increased 23.92-fold and its recovery was 93.79 ± 0.44%. In conclusion, HPD100C demonstrated the best ability for separating isofraxidin among the 26 tested resins.

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Anti-inflammatory effects of a major component of Acanthopanax senticosus Harms, isofraxidin.

Cited by 4 publications

References 10 publications

Targeted Development-Dependent Metabolomics Profiling of Bioactive Compounds in Acanthopanax senticosus by UPLC-ESI-MS

Targeted Development-Dependent Metabolomics Profiling of Bioactive Compounds in Acanthopanax senticosus by UPLC-ESI-MS

Enrichment and Purification of Syringin, Eleutheroside E and Isofraxidin from Acanthopanax senticosus by Macroporous Resin

Preparative enrichment and separation of isofraxidin from Acanthopanax senticosus with HPD100C macroporous resin

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