Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation

Boller, Shirley; Soldi, Cristian; Marques, Maria Consuelo Andrade; Santos, Élide Pereira dos; Cabrini, Daniela Almeida; Pizzolatti, Moacir Geraldo; Zampronio, Aleksander Roberto; Otuki, Michel Fleith

doi:10.1016/j.jep.2010.05.001

Cited by 44 publications

(34 citation statements)

References 29 publications

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“…A representative area was selected for qualitative optical microscopic analysis using 200 · magnification. 37 The effects of the M. marginata honey extract (1.0 mg/ear), dexamethasone (0.05 mg/ear), naive, control (TPA), and vehicle (acetone) were investigated.…”

Section: Histological Analysismentioning

confidence: 99%

Topical Anti-Inflammatory Activity of a Monofloral Honey of Mimosa scabrella Provided by Melipona marginata During Winter in Southern Brazil

Borsato

Prudente²,

Döll-Boscardin³

et al. 2014

Journal of Medicinal Food

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Melipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ± 5%. This extract decreased the myeloperoxidase activity in 75 ± 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ± 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders.

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Section: Histological Analysismentioning

confidence: 99%

Topical Anti-Inflammatory Activity of a Monofloral Honey of Mimosa scabrella Provided by Melipona marginata During Winter in Southern Brazil

Borsato

Prudente²,

Döll-Boscardin³

et al. 2014

Journal of Medicinal Food

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“…1,4,11 Its phytochemical profile reveals a complex source of natural antioxidants as phenolic compounds and carotenoids what makes this pseudofruit an excellent source of antioxidants that can scavenge free radical or reactive oxygen species (ROS), inhibit free radical formation, and prevent damage of cellular components, as well as cellular death. 10,[12][13][14] More recently, the interest and research on the nutritional and medicinal properties of cashew apple and its juice have grown, 11,15 but none of these studies have evaluated the anti-inflammatory and healing potential of cashew apple or juice. Therefore, the present study evaluated the antioxidant, antiinflammatory, and healing properties of cashew apple juice.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and wound healing potential of cashew apple juice (Anacardium occidentale L.) in mice

Vasconcelos

Gomes-Rochette

Oliveira

et al. 2015

Exp Biol Med (Maywood)

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Cashew apple is a tropical pseudofruit consumed as juice due to its excellent nutritional and sensory properties. In spite of being well known for its important antioxidant properties, the cashew apple has not been thoroughly investigated for its therapeutic potential. Thereby, this study evaluated the antioxidant capacity, anti-inflammatory, and wound-healing activities of cashew apple juice. Juices from ripe and immature cashew apples were analyzed for antioxidant, anti-inflammatory, and wound-healing properties. Those were evaluated in murine models of xylene-induced ear edema and wound excision. Swiss mice were treated with cashew juice by gavage. Edema thickness was measured and skin lesions were analyzed by planimetry and histology. Both antioxidant content and total antioxidant activity were higher in ripe cashew apple juice (RCAJ) than in unripe cashew apple juice (UNCAJ). The UNCAJ presented the main anti-inflammatory activity by a significant inhibition of ear edema (66.5%) when compared to RCAJ (10%). Moreover, UNCAJ also showed the best result for wound contraction (86.31%) compared to RCAJ (67.54%). Despite of higher antioxidant capacity, RCAJ did not promote better anti-inflammatory, and healing responses, which may be explained by the fact that treatment increased antioxidants level leading to a redox ''imbalance'' turning down the inflammatory response modulation exerted by reactive oxygen species (ROS). The results suggest that UNCAJ presents a greater therapeutic activity due to a synergistic effect of its phytochemical components, which improve the immunological mechanisms as well as an optimal balance between ROS and antioxidants leading to a better wound healing process.

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“…However, no chemical marker has been established to characterize the Baccharis species (Lonni et al, 2003;Simões-Pires et al, 2005). Several species of this genus that possess cladodes are popularly known as carquejas, and are traditionally used as anti-inflammatory, stomachic and diuretic remedies (Abad and Bermejo, 2007;Lemos et al, 2007;Budel et al, 2008;Boller et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Morpho-anatomical characteristics of Baccharis glaziovii in support of its pharmacobotany

Jasinski

Silva

Pontarolo

et al. 2014

Revista Brasileira de Farmacognosia

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CarquejaMorphology Anatomy Quality control A B S T R A C TBaccharis glaziovii Baker, Asteraceae, also known as carqueja or carqueja-arbustinho, is a native shrub of Brazil that reaches 0.5-2.5 m in height. It is a dioecious species that blossoms from September to December. This species has cladodes, which are winged stems that belong to the "carquejas" and are widely used indiscriminately by the population due to their gastric and diuretic properties. Carquejas are included in section Caulopterae and are difficult to identify even for taxonomists or Baccharis specialists. In the present study, a morpho-anatomical (cladodes and leaves) analysis of the medicinal plant was undertaken to improve its identification and add to the knowledge of section Caulopterae. Fragments of cladodes and leaves were collected and prepared in accordance with standard optical and scanning electron microscopy techniques. The morpho-anatomical characteristics found in B. glaziovii, include three-winged stems showing wings in a regular arrangement around the stem axis, short and petiolate leaves, flagelliform and simple non-glandular trichomes, concave-convex midrib, petioles with a concave shape and a slight projection on the adaxial face and convex with three projections on the abaxial surface, and calcium oxalate crystals in the form of raphides, styloids and pyramidal in the perimedullary region of the cladode, when evaluated as a whole, provide support for the quality control.

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Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation

Abstract: These results indicate that the CE and the active constituents have a topical anti-inflammatory effect and the possible mechanisms for the pharmacological effects are discussed.

Cited by 44 publications

References 29 publications

Topical Anti-Inflammatory Activity of a Monofloral Honey of Mimosa scabrella Provided by Melipona marginata During Winter in Southern Brazil

Topical Anti-Inflammatory Activity of a Monofloral Honey of Mimosa scabrella Provided by Melipona marginata During Winter in Southern Brazil

Anti-inflammatory and wound healing potential of cashew apple juice (Anacardium occidentale L.) in mice

Morpho-anatomical characteristics of Baccharis glaziovii in support of its pharmacobotany

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