Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa

Abdillahi, H.S.; Finnie, J.F.; Staden, J. Van

doi:10.1016/j.jep.2010.07.019

Cited by 69 publications

(33 citation statements)

References 39 publications

(41 reference statements)

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“…Edema was measured 1 h after the dimethylbenzene treatment, and the method is the same as reported in the literature (Abdillahi et al, 2011). The ear swelling was measured by subtracting the weight of the left ear from that of the right.…”

Section: Assay Of Dimethylbenzene-induced Inflammation In Micementioning

confidence: 99%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

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Context: Qi-Wei-Xiao-Yan-Tang (XYT), composed of Radix et Rhizoma Rhei, Radix Astragali, Radix Wikstroemiae Indicae, Fructus Ligustri Lucidi, Poria and Radix Glycyrrhizae, has been widely used as an anti-inflammatory drug.Objective: The present study investigated the anti-inflammatory, antibacterial effects and serum pharmacochemistry of XYT. Methods: The dimethylbenzene-induced inflammation test, the acetic acid-induced vascular permeability test and the carrageenan-induced paw edema test were used to evaluate the antiinflammatory activity of XYT (200, 100 and 50 mg/kg); minimal inhibitory concentration (MIC). Minimal bactericidal concentration (MBC) tests were used to evaluate the antibacterial activity of XYT. Additionally, serum pharmacochemistry was performed to study the biologically active substances. Results: All the tests for anti-inflammatory effects were shown active with these test systems; the anti-inflammatory effects at doses of 100 and 200 mg/kg were significant (p50.05); MIC and MBC tests indicated that XYT showed a broader antimicrobial spectrum and stronger toxicity to the tested microbes. Additionally, calycosin-7-glucoside, sennoside A, aloeemodin and rhein were detected as the predominant components in rat serum which may play the key role in the anti-inflammatory activities of XYT. Conclusions: This is the first report of the pharmacological activities and serum pharmacochemistry of XYT, and the first evidence of anti-inflammatory and antimicrobial properties of the extracts of XYT. The results of our work demonstrated that XYT has significant antiinflammatory and antibacterial properties, and calycosin-7-glucoside, sennoside A aloeemodin and rhein may be the biologically active substances of XYT. XYT can be utilized as an effective and safe disease preventive or therapeutic agent.

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Section: Assay Of Dimethylbenzene-induced Inflammation In Micementioning

confidence: 99%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

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“…Traditionally, it is used to treat joint pain due to rheumatism and arthritis (Abdillahi et al, 2010). Other plants of the Podocarpus genus have been reported to be febrifuge, anti-inflammatory and expectorant (Abdillahi et al, 2011). Majority of the people in the developing countries use different types of this herbal concoction in diarrhea and pain.…”

Section: Introductionmentioning

confidence: 99%

Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

Razan

Tahia²,

Hossain

et al. 2016

Bangla Pharma J

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The methanol extract of leaf of Podocarpus neriifolius D. Don exhibited in vivo peripheral analgesic and antidiarrheal activities in Swiss Albino mice. In the peripheral analgesic activity assay, the methanolic extract showed 50.00 ± 8.57% and 70.25 ± 1.18% inhibition of acetic acid-induced writhing at 200 and 400 mg/kg body weight, respectively. In addition, the extract also revealed a dose dependant inhibition of castor oilinduced diarrhea with 43.77 ± 3.13% and 56.23 ± 6.49% inhibition of feces at 200 and 400 mg/kg body weight, respectively.

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“…Citrus are one of the most extensively studied fruit crops because of their medicinal benefits against coronary diseases, chronic asthma, inflammation, tumors, and blood clotting (Alvarez et al 1986;Bala and Grover 1989;Choi et al 2002;Lagha-Benamrouche and Madani 2013). Epidemiological reports link the multiple medicinal properties of citrus to the presence of bioactive compounds such as phenolics, vitamin C, carotenoids, and flavonoids (Carmeli and Fogelman 2009;Abdillahi et al 2011). In addition to the edible fruit parts of citrus, the non-edible parts, such as the peel, are also rich in bioactive compounds (Asikin et al 2012;Asghar et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Enzyme-assisted Revalorization of Sweet Lime (Citrus limetta Risso) Peel into Phenolic Antioxidants

Mushtaq¹,

Sultana²,

Bhatti³

et al. 2014

BioResources

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Enzymatic treatment was used to induce liberation of antioxidant phenolics from under-utilized sweet lime peel (CLP). Small rotatable central composite design (SRCCD) was selected to optimize the conditions of enzymatic processing, i.e., enzyme concentration (2 to 5%), pH (5 to 8), temperature (30 to 75 °C), and incubation time (30 to 120 min). The morphological characterization of enzymatically hydrolyzed CLP was performed using field emission scanning electron microscopy (FESEM). Extracts obtained under suitable conditions were characterized for their phenolic profile by use of reverse-phase high-performance liquid chromatography coupled with a diode array detector (RP-HPLC-DAD) and evaluated for in vitro antioxidant activities. The observed results revealed that optimum enzymatic pre-treatment doubled the recovery of phenolic antioxidants with maximum Trolox equivalent antioxidant capacity (TEAC) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging potential (IC50). The observed results indicate that enzyme-assisted extraction might be a green choice to revalorize agro-processing residues.

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Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa

Cited by 69 publications

References 39 publications

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

Optimization of Enzyme-assisted Revalorization of Sweet Lime (Citrus limetta Risso) Peel into Phenolic Antioxidants

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