Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

Razan, Rahatullah; Tahia, Faiza; Hossain, Khalid; Rashid, Mohammad A.

doi:10.3329/bpj.v19i2.29283

Cited by 6 publications

(6 citation statements)

References 6 publications

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“…These findings matched well with the previous studies (Neglo et al, 2021;Zamuz et al, 2021). Analgesic activity: Acetic acid-induced writhing in mice model was used to determine the analgesic activity of the extracts (Razan et al, 2016). Here, aceclofenac sodium in 50 mg/kg dose was used as the standard.…”

Section: Antioxidant Activitysupporting

confidence: 87%

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In vitro Antioxidant and In vivo Analgesic Activities of Citrullus lanatus Rind and Flesh Extract: A Comparison

et al. 2022

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The present study was carried out to assess and compare the analgesic and antioxidant potential of Citrullus lanatus rind and flesh extract. The methanolic extract of the rind and ethyl acetate extract of the flesh were evaluated for their in vivo analgesic activity through the acetic acid-induced writhing method on Swiss Albino mice. The free radical scavenging activity of the extracts was measured by total phenolic content measurement and the DPPH method. The flesh extract showed higher antioxidant activity than the rind extract in both methods. In case of the evaluation of analgesic activity, the results were obtained in a dose dependent manner. At 200 and 400 mg/kg doses, both extracts displayed moderate analgesic property in a statistically significant manner (p < 0.05) with respect to aceclofenac sodium. The flesh extract was found to provide a better effect than the rind extract in this case as well. It may be concluded that the ethyl acetate extract of C. lanatus flesh and the methanolic extract of the rind possessed potential antioxidant and analgesic activities and might be used as sources of nutraceuticals or functional foods. Bangladesh Pharmaceutical Journal 25(1): 67-72, 2022 (January)

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Section: Antioxidant Activitysupporting

confidence: 87%

“…The analgesic activity of the methanolic extract of C. lanatus rind and the ethyl acetate extract of the C. lanatus flesh was measured through the established acetic acid-induced writhing method (Razan et al, 2016). This experiment was conducted in-vivo using Swiss Albino mice.…”

Section: Determination Of Analgesic Activitymentioning

confidence: 99%

In vitro Antioxidant and In vivo Analgesic Activities of Citrullus lanatus Rind and Flesh Extract: A Comparison

et al. 2022

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“…Peripheral analgesic activity: Peripheral analgesic activity was evaluated by determining the ability of the test samples to inhibit acetic-acid induced abdominal writhing in mice (Razan et al, 2016).…”

Section: Central Analgesic Activitymentioning

confidence: 99%

Studies of Biological Activities of the Roots of Bombax ceiba L.

Rahman¹,

Rashid²,

Chowdhury³

2019

Bangla Pharma J

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Bioactivities of the methanolic crude extract of root of Bombax ceiba L. and its organic and aqueous soluble partitionates were studied to investigate its medicinal importance. In Free radical scavenging assay by DPPH method, the aqueous soluble partitionate (AQSF) demonstrated the highest free radical scavenging activity with IC50 value of 3.33 ± 0.25 μg/ml. The brine shrimp lethality bioassay of different partitionates of the root demonstrated the significant lethality by the hexane soluble partitionate (HSF) having LC50 value of 1.19 ± 0.10 µg/ml. Among different fractionates of the root, the highest percentage (44.55 ± 0.12%) of clot lysis was exhibited by AQSF. The crude extract revealed promising antidiarrheal, hypoglycemic, central and peripheral analgesic activities at both doses of 200- and 400- mg/kg body weight in Swiss-Albino rat model. Bangladesh Pharmaceutical Journal 22(2): 219-223, 2019

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“…Anti-diarrheal activity: The castor oil-induced diarrheal method, as described by Shoba and Thomas (2001) was used to evaluate the anti-diarrheal activity of CME and PESF (Shoba and Thomas, 2001;Bashar et al, 2019;Razan et al, 2016). To assess the antidiarrheal activity, the animals were divided into six groups each containing four mice.…”

Section: Extraction Of Plant Materialmentioning

confidence: 99%

In vivo Anti-diarrheal and CNS Depressant Activities of Hemigraphis hirta (Vahl) T. Anders.

et al. 2019

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Hemigraphis hirta has been used by folk practitioners to alleviate symptoms of several diseases, although the pharmacological activities of this plant have not been thoroughly explored. The current study was designed to assess the anti-diarrheal and CNS depressant activities of H. hirta in mice model. For both assays, the experimental mice received the methanolic crude extract and its petroleum ether soluble fraction at dose of 200 and 400 mg/kg body weight which are denoted as CME 200, CME 400, PESF 200 and PESF 400, respectively. Both fractions remarkably attenuated castor oil-induced diarrheal effect in a dose-dependent manner and the results were comparable to standard loperamide (89.47%). Among all, PESF 400 exhibited statistically significant (p < 0.01) anti-diarrheal activity as demonstrated by 78.95% inhibition of defacetion. Compared to reference drug diazepam, all the tested samples considerably shortened the time for onset of sleep and prolonged the duration of phenobarbitoneinduced sleep in mice. The results of our present study, being reported for the first time, demonstrate that the methanol extract of leaves of H. hirta and its organic soluble partionates possesses significant anti-diarrheal and CNS depressant properties. However, this preliminary screening requires further detailed investigation to confirm these findings as well as to isolate and characterize the bioactive compounds. Bangladesh Pharmaceutical Journal 22(2): 176-180, 2019

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Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

Cited by 6 publications

References 6 publications

In vitro Antioxidant and In vivo Analgesic Activities of Citrullus lanatus Rind and Flesh Extract: A Comparison

In vitro Antioxidant and In vivo Analgesic Activities of Citrullus lanatus Rind and Flesh Extract: A Comparison

Studies of Biological Activities of the Roots of Bombax ceiba L.

In vivo Anti-diarrheal and CNS Depressant Activities of Hemigraphis hirta (Vahl) T. Anders.

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