Anti-inflammatory, antioxidant and antifungal furanosesquiterpenoids isolated from Commiphora erythraea (Ehrenb.) Engl. resin

Fraternale, Daniele; Sosa, Silvio; Ricci, Donata; Genovese, Salvatore; Messina, Federica; Tomasini, Sabrina; Montanari, Francesca; Marcotullio, Maria Carla

doi:10.1016/j.fitote.2011.02.002

Cited by 47 publications

(40 citation statements)

References 33 publications

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“…Furthermore, it has been reported that C. myrrha mediates its cytoprotective actions by suppressing NO production due to induction of HO-1 (Chen et al, 2005;Zhang et al, 2011). The GC-MS analysis that was carried out in our study indicated the presence of curezerine, deltaelemene, beta-elemene, 3-[(E)-2-phenyl-1-propenyl] cyc, bicycle [3.1.1]hept-2-ene-2-car, 8-isopropenyl-9-isopropyltetra, and 2,4-bis(3-methyl-1-pentynyl)-4, which were reported to have antioxidant, cytoprotective as well as anticancer properties (Fraternale et al, 2011;Marcotullio et al, 2011;Racine & Auffray, 2005). Liver histological changes to the inflammatory response such as fatty changes, focal central vein congestion, vocalization, necrosis, and loss of cellular boundaries were visible throughout many lobules in the D-GalN/LPS-administered group.…”

Section: Discussionmentioning

confidence: 79%

“…Previous phytochemical investigations of C. myrrha resin revealed that terpenoids were the characteristic constituents (Su et al, 2009). Moreover, it has been demonstrated that some of the extracts or active principles obtained from plants of the Burseraceae family have a broad spectrum of biological activities including anti-bacterial, anti-nociceptive, antiinflammatory, hepatoprotective, and anti-ulcer activity (Fraternale et al, 2011;Gowri Shankar et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

Ahmad

Raish

Ganaie

et al. 2015

Pharmaceutical Biology

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(2015) Hepatoprotective effect of Commiphoramyrrha against d-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes, Pharmaceutical Biology, 53:12, 1759-1767, DOI: 10.3109/13880209.2015 Results: The administration of D-GalN/LPS increased plasma aminotransferases (174.47 ± 4.5761 and 260.96 ± 1.9839 mkat/l) and total bilirubin levels (1.012 ± 0.0288 mg/dl), which were attenuated by C. myrrha treatment. Hepatic lipid peroxidation activity and nitric oxide content also increased, while the antioxidant activity measured by GSH (0.76 nmol/g protein), SOD (81.91 U/mg protein), and CAT (15.78 U/mg protein) was reduced. Commiphora myrrha provided significant restoration of GSH (0.815 nmol/gm protein), SOD (140.57 U/mg protein), and CAT (27.02 U/mg protein) levels. Furthermore, the acute phase response elicited by D-GalN/ LPS administration enhanced mRNA expressions of TNF-a, IL-6, IL-10, iNOS-2, and HO-1, which were ameliorated by C. myrrha treatment. Discussion and conclusion: These findings indicate that C. myrrha considerably reduces the oxidative stress of D-GalN/LPS-induced hepatic injury via multiple pathways including adown regulation of inflammatory mediators and cytokines. Such a property might be sufficient to combat cellular damage caused by various conditions that resemble fulminant hepatitis and could be of a potential clinical application.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

Ahmad

Raish

Ganaie

et al. 2015

Pharmaceutical Biology

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“…After 4 weeks of treatment the wound healed completely. Although myrrh's exact role in wound healing is difficult to determine because of many confounding factors in this case report, data suggest there may be a potential role for topically applied products containing myrrh (Lotfy et al, 2006;Gallo et al, 1999;Fraternale et al, 2011). Also, it is not possible to make a direct correlation between the observed activity of the oleo-gum resins in vitro and the actual effects when used in vivo for the diseases observed by the indigenous people and traditional healers.…”

Section: Czapek-dox Medium (G)* -------------------------------------mentioning

confidence: 77%

An Evaluation of the Antimicrobial Activity of Commiphora myrrha Nees (Engl.) Oleo-gum Resins from Saudi Arabia

Alhussaini¹,

Saadabi²,

Alghonaim³

et al. 2015

J. of Medical Sciences

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The present work was aimed to evaluate oleo-gum resins aqueous, methanol and chloroform extracts of Commiphora myrrha for antimicrobial activity against four types of bacteria and twelve species and strains of fungi. All of the oleo-gum resin extracts irrespective of their types inhibited the growth of all microbes to varying degrees. Aqueous extract showed the least antibacterial and antifungal activity against all of the pathogens used especially with regard to gram positive bacteria Staphylococcus aureus (11 mm) and Escherichia coli (11 mm) in concentration of 100 mg mLG 1 as compared to methanol or chloroform. Less or no activity was observed against Trichophyton concentricum (7.01 mm) and 4.01 mm inhibition zone for Candida rugosa in the same concentration used. The oleo-gum resins methanol extracts in different concentrations were significantly inhibitory to the growth of the different tested fungal dermatophytes. Reduction in mycelial weight of fungi was directly correlated with concentration of extract. The concentration of 200 mg mLG 1 of myrrha was the most inhibitory against Epidermophyton floccosum with 2 g mycelial fresh weight while the less inhibition in the growth was obtained in Candida albicans and it was 6.61 g in the same extract concentration. The other used fungal or bacterial groups showed varying degrees of activity pending on the type of extract used. The Minimum Inhibitory Concentration (MIC) values of methanol and aqueous extracts of oleo-gum resins of myrrh showed that the highest values were obtained in methanol extract for Trichophyton concentricum and lowest MIC values for the same extract for the bacterium Staphylococcus aureus. In the aqueous extract of myrrha the highest and lowest MIC values were found for Bacillus subtilis and Pseudomonas aeruginosa. Phytochemical analyses showed the presence of Sesquiterpenes (Isoprenoids i.e., Terpenoids) and Furanosesquiterpenes as major constituents of the oleo-gum resins of the plant. These results confirm the antibacterial and antifungal activity of gum resins and support the traditional use of the myrrh in therapy of bacterial infections.

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“…A recent review on the chemical constituents of the Lychnophorinae tribe has revealed significant variation in the occurrence of secondary metabolites in the genus Lychnophora [12]. Considering a single species, three phenomena can account for the observed differences: (a) accomplishment of a phytochemical investigation looking for a specific class of target secondary metabolites only, such as sesquiterpene lactones [13,14]; (b) performance of bioguided fractionation, which inspects a typical biological activity and may result in the isolation of a common class of secondary metabolites [15][16][17]; and (c) natural chemical variations in metabolism or presence of chemotypes [6][7][8]10].…”

Section: Introductionmentioning

confidence: 99%

A new HPLC-DAD-MS/MS method for the simultaneous determination of major compounds in the crude extract of Lychnophora salicifolia Mart. (Brazilian arnicão) leaves: Application to chemical variability evaluation

Gouvea¹,

Meloni²,

Ribeiro³

et al. 2012

Analytica Chimica Acta

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Anti-inflammatory, antioxidant and antifungal furanosesquiterpenoids isolated from Commiphora erythraea (Ehrenb.) Engl. resin

Cited by 47 publications

References 33 publications

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

An Evaluation of the Antimicrobial Activity of Commiphora myrrha Nees (Engl.) Oleo-gum Resins from Saudi Arabia

A new HPLC-DAD-MS/MS method for the simultaneous determination of major compounds in the crude extract of Lychnophora salicifolia Mart. (Brazilian arnicão) leaves: Application to chemical variability evaluation

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