Anti-inflammatory, anti-angiogenetic and antiviral activities of dammarane-type triterpenoid saponins from the roots of <i>Panax notoginseng</i>

Zheng, Yanfang; Fan, Chun‐Lin; Chen, Ye; Quan, Jingyu; Shi, Ling-Zhu; Tian, Chunyang; Shang, Xiao; Xu, Nishan; Ye, Wen-Cai; Yu, Linzhong; Liu, Junshan

doi:10.1039/d1fo04089h

Cited by 25 publications

(8 citation statements)

References 35 publications

(37 reference statements)

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“… 19 Only recently, in early 2022, Notoginseng isolates were found to show anti-Dengue activity in Zebrafish. 20 A recent report in 2021 on medicinal plants against Dengue virus has not highlighted Ginseng or Notoginseng as potential herbs against the virus. 21 With the antiviral activities and a wide range of health benefits of Ginseng and Notoginseng extracts and isolates, we explore the potential of chemicals found in Panax Ginseng and/or Panax Notoginseng as antiviral agents against Dengue NS5 Methyl transferase (MTase).…”

Section: Introductionmentioning

confidence: 99%

In silico and in vitro studies of potential inhibitors against Dengue viral protein NS5 Methyl Transferase from Ginseng and Notoginseng

Jarerattanachat

Boonarkart

Hannongbua

et al. 2023

Journal of Traditional and Complementary Medicine

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Section: Introductionmentioning

confidence: 99%

In silico and in vitro studies of potential inhibitors against Dengue viral protein NS5 Methyl Transferase from Ginseng and Notoginseng

Jarerattanachat

Boonarkart

Hannongbua

et al. 2023

Journal of Traditional and Complementary Medicine

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“…The main active ingredient of Panax Notoginseng (Burk.) F. H. Chen Ex C. Chow has been widely studied for its applications such as anti-inflammatory effects ( 53 , 54 ). Pharmacologically, the function of YS has been confirmed to improve pulmonary function and ventilatory dysfunction and played an important role in repairing inflammatory damage in COPD animals.…”

Section: Discussionmentioning

confidence: 99%

Yifei Sanjie Formula Treats Chronic Obstructive Pulmonary Disease by Remodeling Pulmonary Microbiota

Meng²,

Qiao³

et al. 2022

Front. Med.

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Chronic obstructive pulmonary disease (COPD) is one of the most common pulmonary diseases. Evidence suggests that dysbiosis of pulmonary microbiota leads to the COPD pathological process. Yifei Sanjie Formula (YS) is widely used to treat diseases in respiratory systems, yet little is known about its mechanisms. In the present study, we first established the fingerprint of YS as the background for UHPLC-QTOF-MS. Components were detected, including alkaloids, amino acid derivatives, phenylpropanoids, flavonoids, terpenoids, organic acids, phenols, and the like. The therapeutic effect of YS on COPD was evaluated, and the pulmonary function and ventilatory dysfunction (EF50, TV, and MV) were improved after the administration of YS. Further, the influx of lymphocytes was inhibited in pulmonary parenchyma, accompanied by down-regulation of inflammation cytokines via the NLRP3/caspase-1/IL-1β signaling pathway. The severity of pulmonary pathological damage was reversed. Disturbed pulmonary microbiota was discovered to involve an increased relative abundance of Ralstonia and Mycoplasma and a decreased relative abundance of Lactobacillus and Bacteroides in COPD animals. However, the subversive effect was shown. The abundance and diversity of pulmonary microflora were remodeled, especially increasing beneficial genua Lactobacillus and Bacteroides, as well as downregulating pathogenic genua Ralstonia and Mycoplasma in the YS group. Environmental factor correlation analysis showed that growing pulmonary microbiota was positively correlated with the inflammatory factor, referring to Ralstonia and Mycoplasma, as well as negatively correlated with the inflammatory factor, referring to Lactobacillus and Bacteroides. These results suggest that the effects of YS involved remodeling lung microbes and anti-inflammatory signal pathways, revealing that intervention microbiota and an anti-inflammatory may be a potential therapeutic strategy for COPD.

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“…Plants containing saponins are used to heal wounds and also possess anti-inflammatory activities (Costa et al, 2011;Zheng et al, 2022).…”

Section: Phytochemical Analysismentioning

confidence: 99%

Anti-inflammatory potential of Secamone afzelii extract: A study of Ivorian traditional plant on experimental rats

Landry¹,

Akoua²,

Jean-Michel³

et al. 2022

Asian J Pharm Pharmacol

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Objectives:aqueous leaves extract is used in traditional Ivorian medicine to fight against gastric disorders, S. afzelii colic, dysentery and kidney problems. This study aimed was to compare decoction and methanolic phytochemical composition of extracts from aerial parts and evaluate anti-inflammatory potential of this plant, in order to S. afzelii bring out solid scientific argument which can justify its use in many pathologies.: Phytochemical screening of Methods aqueous decoction and hydro methanolic extracts obtained from leaves of was evaluated with standard S. afzelii methods. Aqueous decoction was submitted first in rat's paw irritation test induced by formalin and secondary rat's paw oedema induced by carrageenan test was performed to appreciate anti-inflammatory activity.: Qualitative Results phytochemical screening showed presence of tannins, saponins, flavonoids, sterols, terpenoids and coumarins in both extracts. All doses evaluated in formalin test (25-50-100 and 200 b.wt.) have reduced significantly production of chemical inflammation mediators respectively up to 59.09%; 54.22%; 54.10% and 62.88% with an effect comparable to ketoprofen which was 55.56%. Concerning carrageenan-induced oedema test, strong limited oedema evolution was observed at 10 b.wt., with 60.28%, 66.92%, 61.30% and 45.29% respectively at 1 , 2 , 3 and 4 hours. However, these st nd rd th effects are not superior to ketoprofen, which decrease during 4 hours up 71.35, 73.69, 68.87 and 57.06%. : Conclusion Aqueous leaves and hydro methanolic extracts of revealed presence of flavonoids, saponins, sterols, S. afzelii terpenoids, tannins and coumarins. Aqueous leaves of possessed good anti-inflammatory potential.

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Anti-inflammatory, anti-angiogenetic and antiviral activities of dammarane-type triterpenoid saponins from the roots of Panax notoginseng

Abstract: Fifteen dammarane-type triterpenoid saponins including one new compound isolated from P. notoginseng exhibited anti-inflammatory, anti-angiogenetic and antiviral activities.

Cited by 25 publications

References 35 publications

In silico and in vitro studies of potential inhibitors against Dengue viral protein NS5 Methyl Transferase from Ginseng and Notoginseng

In silico and in vitro studies of potential inhibitors against Dengue viral protein NS5 Methyl Transferase from Ginseng and Notoginseng

Yifei Sanjie Formula Treats Chronic Obstructive Pulmonary Disease by Remodeling Pulmonary Microbiota

Anti-inflammatory potential of Secamone afzelii extract: A study of Ivorian traditional plant on experimental rats

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