Anti-inflammatory potential of Secamone afzelii extract: A study of Ivorian traditional plant on experimental rats

Abstract

Objectives:aqueous leaves extract is used in traditional Ivorian medicine to fight against gastric disorders, S. afzelii colic, dysentery and kidney problems. This study aimed was to compare decoction and methanolic phytochemical composition of extracts from aerial parts and evaluate anti-inflammatory potential of this plant, in order to S. afzelii bring out solid scientific argument which can justify its use in many pathologies.: Phytochemical screening of Methods aqueous decoction and hydro methanolic extracts obtained from leaves of was evaluated with standard S. afzelii methods. Aqueous decoction was submitted first in rat's paw irritation test induced by formalin and secondary rat's paw oedema induced by carrageenan test was performed to appreciate anti-inflammatory activity.: Qualitative Results phytochemical screening showed presence of tannins, saponins, flavonoids, sterols, terpenoids and coumarins in both extracts. All doses evaluated in formalin test (25-50-100 and 200 b.wt.) have reduced significantly production of chemical inflammation mediators respectively up to 59.09%; 54.22%; 54.10% and 62.88% with an effect comparable to ketoprofen which was 55.56%. Concerning carrageenan-induced oedema test, strong limited oedema evolution was observed at 10 b.wt., with 60.28%, 66.92%, 61.30% and 45.29% respectively at 1 , 2 , 3 and 4 hours. However, these st nd rd th effects are not superior to ketoprofen, which decrease during 4 hours up 71.35, 73.69, 68.87 and 57.06%. : Conclusion Aqueous leaves and hydro methanolic extracts of revealed presence of flavonoids, saponins, sterols, S. afzelii terpenoids, tannins and coumarins. Aqueous leaves of possessed good anti-inflammatory potential.