Anti-inflammatory and phytochemical evaluation of Combretum aculeatum Vent growing in Sudan

Hamad, Kamal M.; Sabry, Manal M.; El-Gayed, Sabah H.; Shabrawy, Abdel-Rahman El; El-Fishawy, Ahlam M.; Jaleel, Gehad A. Abdel

doi:10.1016/j.jep.2019.112052

Cited by 14 publications

(7 citation statements)

References 32 publications

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“…Several studies have acknowledged that the subplantar administration of carrageenan leads to significant infiltration of several proinflammatory markers. 19,20 The results from this study were in agreement with these previous studies as the subplantar injection of carrageenan brought about visible signs of paw edema and liberation of inflammatory-related mediators (TNF-α, IL-1β, and IL-6).…”

supporting

confidence: 91%

Anti-Inflammatory Activities of Kukoamine A From the Root Bark of Lycium chinense Miller

Wang

et al. 2020

Natural Product Communications

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Kukoamine A (Kuk A) is a naturally occurring bioactive spermine alkaloid found in the root bark of Lycium chinense, and it exerts various therapeutic effects including antioxidant, neuroprotective, anti-inflammatory, and antidiabetic effects. This study evaluated the anti-inflammatory properties of Kuk A against lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophage cells and carrageenan-induced paw edema in rats. Pretreatment of cells with Kuk A significantly inhibited the production of reactive oxygen species, nitric oxide, prostaglandin E2, cyclooxygenase-2 activity, tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-6 in LPS-treated cells. In addition, pretreatment of rats with Kuk A significantly decreased inflammatory response to carrageenan-induced paw edema by alleviating proinﬂammatory cytokines in the serum, malondialdehyde levels in the liver and increasing the activities of liver antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) of carrageenan-treated rats. These results suggest the protective role of Kuk A in acute inflammatory reaction and could be useful in the treatment of inflammatory-related disorders.

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supporting

confidence: 91%

Anti-Inflammatory Activities of Kukoamine A From the Root Bark of Lycium chinense Miller

Wang

et al. 2020

Natural Product Communications

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“…The antiviral activity of indomethacin was shown to be associated with blocking viral replication [90] . However, another interesting pharmacological effect of indomethacin that could contribute to COVID-19 patient recovery is its capacity to modulate cytokine production [91] , [92] , particularly the robust effect this drug has on reducing the release of proinflammatory IL-6 [93] . The ability of indomethacin to attenuate inflammatory processes in combination with its antiviral properties make it a good candidate in the fight against the coronavirus.…”

Section: Drug Repurposing For Covid-19 and Affected Cytokinesmentioning

confidence: 99%

“…It has been suggested that anti-inflammatory drugs could be used as adjuvant drugs to mitigate the severity of COVID-19 due to their capacity to attenuate the release of inflammatory mediators such as IL-6, TNF-α and IL-1β [92] ( Fig. 2 ).…”

Section: Drug Repurposing For Covid-19 and Affected Cytokinesmentioning

confidence: 99%

Drug repurposing and cytokine management in response to COVID-19: A review

Heimfarth

Serafini

Martins-Filho

et al. 2020

International Immunopharmacology

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Highlights Rational strategy to carry out drugs repurposing for management COVID-19 patients. Anti-inflammation therapy plays a pivotal role in the management COVID-19 patients. Drugs mitigate the cytokines production induced by SARS-CoV-2‘s immunological activation. Reduction in hyperinflammation lead to a decrease in multiple organ failure.

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“…In this mouse model of paw edema, the extract EHA-Lr significantly reduced edema volume and showed superior inhibition compared to indomethacin. The paw edema induced by carrageenan in rats is associated with the synthesis of mediators involved in the inflammatory process (Farça et al 2001;Hamad et al 2019;Sharma et al 2020). Among these we can highlight some of the most relevant ones such as: histamine, serotonin, bradykinin, nitric oxide and prostaglandins, whose release is closely related to the chemotaxis process of cells in particular leukocytes to the inflammatory sites (Farça et al 2001;Hajare et al 2001).…”

Section: Carrageenan-induced Paw Edema Testmentioning

confidence: 99%

Antioxidant, anti-inflammatory and antimicrobial activities promoted by hydroalcoholic extract of Laguncularia racemosa (l) c.f. leaves Gaert

Dias¹,

Júnior²,

Costa³

et al. 2022

IJAERS

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This study aimed to evaluate the antioxidant, anti-inflammatory, antimicrobial and toxicity potential of the hydroalcoholic extract of the leaves of L. racemosa (EHALr) a mangrove plant. The results showed that the extract was able to promote moderate antioxidant activity. In acute toxicity assays, EHA-Lr showed low toxicity, with no significant changes in animal and organ weights and in biochemical and hematological parameters. In the evaluation of anti-inflammatory activity, the 200 mg/kg dose of EHA-Lr was most effective in reducing leukocyte migration in the paw edema model and in the LPS-induced acute lung inflammation model the 50 mg/kg dose was most effective in reducing plantar volume. The antimicrobial potential of the hydroalcoholic extract was observed against Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Pseudomonas aeruginosa, Serratia marcencens, Escherichia coli and Enterococcus faecalis strains, proving to be effective. However, the extract was most active against the Micrococcus luteus strain (0.93mg/mL). The hydroalcoholic extract of L. racemosa leaves showed anti-inflammatory and antimicrobial activities, with low toxicity, which makes it a strong promise to be applied or combined in clinical therapy.

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Anti-inflammatory and phytochemical evaluation of Combretum aculeatum Vent growing in Sudan

Cited by 14 publications

References 32 publications

Anti-Inflammatory Activities of Kukoamine A From the Root Bark of Lycium chinense Miller

Anti-Inflammatory Activities of Kukoamine A From the Root Bark of Lycium chinense Miller

Drug repurposing and cytokine management in response to COVID-19: A review

Antioxidant, anti-inflammatory and antimicrobial activities promoted by hydroalcoholic extract of Laguncularia racemosa (l) c.f. leaves Gaert

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