Anti-inflammatory and hemostatic effects of Linaria reflexa Desf

Abstract

The work presented here was aimed to investigate the in vivo anti-inflammatory and in vitro hemostatic activities of Linaria reflexa extract and to establish the relationship between its bioactivity and chemical composition. Twenty-three secondary metabolites were identified, most of them are good anti-inflammatory agents, in line with data by carrageenin-induced rat paw edema assays of the n-butanol extract showing high anti-inflammatory inhibition (63.90%) of edema swelling in the rat paw at the dose 200 mg/kg after 4 h. Furthermore, both extent of inflammatory response and tissue injury were prevented keeping the levels of rate myeloperoxidase (60.16%) and of malondialdehyde, which is the final product of lipid peroxidation generated by free radicals (58.58%). The same extract showed also a remarkable hemostatic effect established by measuring the coagulation time of decalcified plasma (45 s), related to its flavonoid glycosides content.

Centaurea behen leaf extract mediated green synthesized silver nanoparticles as antibacterial and removing agent of environmental pollutants with blood compatible and hemostatic effects

“…They explained that the decreased blood clotting time against AgNPs can be due to phytochemical of A. wilhelmsii extract as capping agents in the surface of biosynthesized AgNPs and also, negative charges of these NPs 87 . According to a previous report, the presence of high amount of flavonoid glycosides in the extract of some medicinal plants causes a potent hemostatic effect 88 . It has been reported that various species of the genus Centaurea have high amounts of flavonoids.…”

A literature review of bioactive substances for the treatment of periodontitis: In vitro, in vivo and clinical studies

“…The potential of red algae ethanol extract as an anti-inflammatory agent for periodontitis has been widely studied [ [105] , [106] , [107] ]. However, the anti-inflammatory activity of Gracilaria textorii ethanol extract (GTEE) has not yet been reported.…”