Anti-Inflammatory and Antioxidant Properties of Coffea Arabica/Reduced Graphene Oxide Nanocomposite prepared by green synthesis

Abstract

The present study focuses on an efficient eco-friendly method for reducing graphene oxide (rGO) using Coffea arabica leaf extract for bio-medical applications for the first time to the best of our knowledge. The reduction of graphene oxide (GO) using Coffea arabica leaves was verified through Raman, X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM). The XRD peaks corresponding to GO at 2 =10º have dissapeared on reduction of GO to rGO and the formation of rGO was verified through a new broad peak at 2 =26º. FTIR revealed functional group changes in reducing GO to rGO. The SEM images of rGO showed a ribbed form instead of the rigid appearance of the GO flakes. The analysis revealed that the current green method is a feasible method for reducing GO to rGO and formation of the Coffea arabica/rGO nanocomposite. The composite prepared from young coffee leave exhibited higher antioxidant capacity than matured leave against scavenging 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radicals. Fascinatingly, the Coffea arabica/rGO nanocomposite showed an anti-inflammatory activity as well suggesting that the Coffea arabica /rGO nanocomposite is promising candidate for bio-medical applications in near future.

Zinc oxide nanoparticles synthesized using coffee leaf extract assisted with ultrasound as nanocarriers for mangiferin

“…The biologically active compounds in coffee leaves are excellent reductants, capping agents, and stabilizers that can be used to green synthesis of NPs. Coffee leaf extract (CLE) has been used to synthesize reduced graphene oxide nanocomposite which possessed antioxidant and anti-inflammatory activities ( Perera et al, 2021 ). To our best knowledge, there is no research using coffee leaves to synthesize ZnO NPs.…”

Optimization of reduced graphene oxide production using central composite design from Pennisetum glaucum for biomedical applications

“…More interestingly our study also proves that both GO and rGO showed relatively better scavenging effects of free radicals. Since the basal hydroxyl group disturbs the radical stabilization, GO provides less strong free radical scavenging property compared with positive control 51 . From the experimental data, the IC 50 value for reference standard ascorbic acid was 38.7272 μg/ml, for GO 48.77 μg/ml, and rGO 92.30 μg/ml.…”

Potential Biomedical Limitations of Graphene Nanomaterials

“… 117–120 Targeted delivery systems for anti-inflammatory drugs have also been investigated, such as loading the anti-inflammatory drug ibuprofen into a graphene oxide-chitosan system. 121 In summary, GFNs have been shown to play an important role in DDS and are favored by many researchers for their ability to rapidly deliver drugs and precisely target specific areas ( Table 1 ).…”