Anti-inflammatory and antioxidant properties of <i>Helichrysum italicum</i>

Sala, Araceli; Recio, M. C.; Giner, Rosa M.; Máñez, Salvador; Tournier, Horacio; Schinella, Guillermo Raúl; Rı́os, José-Luis

doi:10.1211/0022357021778600

Cited by 187 publications

(120 citation statements)

References 16 publications

(27 reference statements)

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“…Finally, when chronic inflammation was induced by multiple applications of 2 Pg of TPA, the ear edema was reduced by 65, 44 and 48 % with 200 mg.kg -1 of the methanolic extract, hexane and CH 2 Cl 2 fraction, respectively, whereas the leukocyte infiltration was reduced by all the fractions (40-66 %) and the methanolic extract (58 %). The authors concluded that the anti-inflammatory activity of these extracts might be due to pro-inflammatory enzyme inhibition, free radical scavenging activity or effects similar to the ones induced by corticoids (Sala et al, 2002).…”

Section: In Vivo Studiesmentioning

confidence: 99%

Helichrysum italicum: From traditional use to scientific data

Viegas¹,

Palmeira‐de‐Oliveira²,

Salgueiro³

et al. 2014

Journal of Ethnopharmacology

128

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Ethnopharmacological relevanceHelichrysum italicum (Roth) G. Don fil. (family Asteraceae) has been used for its medicinal properties for a long time and, even nowadays, continues to play an important role in the traditional medicine of Mediterranean countries. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. Aim of the reviewTo provide an overview of the current state of knowledge of the pharmacological activities of H. italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methodsThe selection of relevant data was made through a search using the keywords "Helichrysum italicum" and "H. italicum" in "Directory of Open Access Journals", "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect" and "Wiley Online Library". Information obtained in local and foreign books and other sources was also included. ResultsThere are reports on the traditional use of H. italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections and sleeplessness. In order to validate some of the traditional uses of H. italicum italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acetophenones and phloroglucinols, as seen in animal models. Concerning its safety and adverse effects, while H. italicum does not display significant levels of cytotoxicity or genotoxicity, it should be noticed that one of its flavonoids inhibited some CYP isoforms and a case has been reported of an allergic reaction to its extracts. Aim of the reviewTo provide an overview of the current state of knowledge of the pharmacological activities of H. italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methodsThe selection of relevant data was made through a search using the keywords "Helichrysum italicum" and "H. italicum" in "Directory of Open Access Journals", "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect" and "Wiley Online Library". Information obtained in local and foreign books and other sources was also included. ResultsThere are reports on the traditional use of H. italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acet...

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Section: In Vivo Studiesmentioning

confidence: 99%

Helichrysum italicum: From traditional use to scientific data

Viegas¹,

Palmeira‐de‐Oliveira²,

Salgueiro³

et al. 2014

Journal of Ethnopharmacology

128

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“…119 In many cases, increased oxidative stress is a widely associated in the development and progression of diabetes and its complications which are usually accompanied by increased production of free radicals or failure of antioxidant defense. 120 Though the intake of natural antioxidants has been reported to reduce risk of cancer, cardiovascular diseases, diabetes and other diseases associated with aging, there is considerable controversy in this area.…”

Section: Uses Of Antioxidants In Technologymentioning

confidence: 99%

Antioxidants: An Overview on the Natural and Synthetic Types

Atta¹,

Mohamed²,

Abdelgawad³

2017

ECB

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“…The outstanding fact is that, use of natural medicine treatments is referred to any age groups and the sex antiviral activities. The ingestion of natural antioxidants has been associated with reduced risks of cancer, cardiovascular disease, diabetes, and other diseases associated with ageing 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Preliminary Phytochemical Screening and In vitro Antioxidant Activity of Nigella sativa and Allium cepa Oil

Chachoo¹,

Jain²

2018

PBJ

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Many oxidative stress related diseases are as a consequence of accumulation of free radicals in the body. The various researches are going on globally directed towards finding natural antioxidants of plants origins. We planned to investigate the preliminary phytochemical screening and in vitro antioxidant activity of Nigella sativa and Allium cepa oil.The yield of oil of Nigella sativa and Allium cepa were 21.5% and 27.3%, respectively.Phytochemical screening was performed by using standard methods. The in vitro antioxidant study was done for Nigella sativa and Allium cepa oil by using hydrogen-donating activity, superoxide scavenging activity, hydrogen peroxide scavenging assay and reducing power assay. The result of phytochemical screening demonstrated the presence of flavonoids, steroids and fats in Nigella sativa and Allium cepa oil. The findings of DPPH, superoxide, reducing power and H2O2 radical scavenging activity exhibited that the oil of Nigella sativa and Allium cepa showed moderately to strongly free radical scavenging activity. Hence Nigella sativa and Allium cepa oil can play a major role in alleviating the number of oxidative stress by reducing the oxidative damage to cellular component caused by Reactive oxygen species (ROS).

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Anti-inflammatory and antioxidant properties of Helichrysum italicum

Cited by 187 publications

References 16 publications

Helichrysum italicum: From traditional use to scientific data

Helichrysum italicum: From traditional use to scientific data

Antioxidants: An Overview on the Natural and Synthetic Types

Preliminary Phytochemical Screening and In vitro Antioxidant Activity of Nigella sativa and Allium cepa Oil

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