Anti-inflammatory and antinociceptive activities of Croton urucurana Baillon bark

Cordeiro, Kátia Wolff; Felipe, José Luis; Malange, Kauê Franco; Prado, Pâmela Rafaela do; Figueiredo, Patrícia de Oliveira; Garcez, Fernanda Rodrigues; Freitas, Karine de Cássia; Garcez, Walmir Silva; Toffoli-Kadri, Mônica Cristina

doi:10.1016/j.jep.2016.02.051

Cited by 45 publications

(35 citation statements)

References 37 publications

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“…In turn, another research group demonstrated that MGN isolated from fruit of Ziziphus jujube shows a very weak, statistically insignificant cytotoxic effect against MCF7 breast cancer, A549 lung cancer, HepG2 hepatocellular carcinoma, and HT-29 colon cancer cell lines [32].…”

Section: Anticancer Activitymentioning

confidence: 99%

Advances in Chemistry and Bioactivity of Magnoflorine and Magnoflorine-Containing Extracts

Okon

Kukuła-Koch

Jarząb

et al. 2020

IJMS

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The review collects together some recent information on the identity and pharmacological properties of magnoflorine, a quaternary aporphine alkaloid, that is widely distributed within the representatives of several botanical families like Berberidaceae, Magnoliaceae, Papaveraceae, or Menispermaceae. Several findings published in the scientific publications mention its application in the treatment of a wide spectrum of diseases including inflammatory ones, allergies, hypertension, osteoporosis, bacterial, viral and fungal infections, and some civilization diseases like cancer, obesity, diabetes, dementia, or depression. The pharmacokinetics and perspectives on its introduction to therapeutic strategies will also be discussed.

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Section: Anticancer Activitymentioning

confidence: 99%

Advances in Chemistry and Bioactivity of Magnoflorine and Magnoflorine-Containing Extracts

Okon

Kukuła-Koch

Jarząb

et al. 2020

IJMS

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“…As non-steroidal anti-inflammatory drugs (NSAIDs) are frequently applied in the treatment of various diseases because of their wide range of therapeutic effects (Cordeiro et al, 2016), traditional Chinese medicine has become a popular research area. Exocarpium Citri Grandis (ECG), which is also named as Huajuhong in China, has been widely used as an anti-inflammatory, antitussive and expectorant agent (Jiang et al, 2014) for more than 1500 years in China (Yu, Liu, Xie, Lam, & Xu, 2014).…”

Section: Introductionmentioning

confidence: 99%

Flavonoids derived from Exocarpium Citri Grandis inhibit LPS-induced inflammatory response via suppressing MAPK and NF-κB signalling pathways

Peng

Lü

et al. 2019

Food and Agricultural Immunology

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Pan (2019) Flavonoids derived from ExocarpiumCitriGrandis inhibit LPS-induced inflammatory response via suppressing MAPK and NF-κB signalling pathways, Food and Agricultural Immunology, 30:1, 564-580, ABSTRACT Exocarpium Citri Grandis (ECG) is used as an antitussive and antiinflammatory agent in traditional Chinese medicine. However, the mechanism of its anti-inflammatory effect remains unknown. In this study, flavonoids of ECG (FECG) were extracted to investigate the anti-inflammatory effect using a RAW264.7 macrophage model. The results suggested that FECG could remarkably inhibit the production of nitric oxide (NO). Meanwhile, FECG decreased the mRNA and protein expression of inflammatory cytokines including tumour necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), while showed an opposite effect on interleukin-10 (IL-10). Furthermore, FECG suppressed the phosphorylation of p38 (p38 kinase), JNK (c-Jun N-terminal kinase), ERK (extracellular signal-regulated kinase) and NF-κB. Taken together, our results indicated that FECG might regulate the activation of MAPK and NF-κB signalling pathways to exert anti-inflammatory effects. This study provides some insights into the mechanism underlying the anti-inflammatory activity of ECG, which may facilitate a better application of ECG. ARTICLE HISTORY

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“…Popularly known as sangra d´água, it is used as antiinflammatory, anti-hemorrhagic, healing, in the fight against prostate cancer, diabetes and kidney disease (ANTONIAZZI et al, 2016). Some studies report the chemical composition and biological actions for latex, essential oil and different parts of the plant, highlighting cytotoxic, antimicrobial and antinociceptive activities (CANDIDO-BACANI et al, 2015;SIMIONATTO et al, 2007;SIMIONATTO et al, 2009;VIEIRA et al, 2017;CORDEIRO et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

ANTIOXIDANT ACTIVITY AND TOTAL PHENOL, FLAVONOID AND TANNIN CONTENTS OF Croton floribundus AND Croton urucurana

Silva¹,

Feitosa²,

Lima³

et al. 2019

Enci Bio

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Anti-inflammatory and antinociceptive activities of Croton urucurana Baillon bark

Cited by 45 publications

References 37 publications

Advances in Chemistry and Bioactivity of Magnoflorine and Magnoflorine-Containing Extracts

Advances in Chemistry and Bioactivity of Magnoflorine and Magnoflorine-Containing Extracts

Flavonoids derived from Exocarpium Citri Grandis inhibit LPS-induced inflammatory response via suppressing MAPK and NF-κB signalling pathways

ANTIOXIDANT ACTIVITY AND TOTAL PHENOL, FLAVONOID AND TANNIN CONTENTS OF Croton floribundus AND Croton urucurana

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