Advances in Chemistry and Bioactivity of Magnoflorine and Magnoflorine-Containing Extracts

Abstract

The review collects together some recent information on the identity and pharmacological properties of magnoflorine, a quaternary aporphine alkaloid, that is widely distributed within the representatives of several botanical families like Berberidaceae, Magnoliaceae, Papaveraceae, or Menispermaceae. Several findings published in the scientific publications mention its application in the treatment of a wide spectrum of diseases including inflammatory ones, allergies, hypertension, osteoporosis, bacterial, viral and fungal infections, and some civilization diseases like cancer, obesity, diabetes, dementia, or depression. The pharmacokinetics and perspectives on its introduction to therapeutic strategies will also be discussed.

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“…One of the most popular alkaloids is magnoflorine (MGN), which is synthesized by plants from the Ranunculaceae, Menispermaceae and Magnoliaceae families [1]. MGN is a quaternary isoquinolone alkaloid, specifically an aporphyrin derivative [2,3]. These compounds are synthesized from benzylisoquinolines in the process of subtraction of two hydrogen atoms, thus creating the 9,10-dihydrophenanthrene structure from two benzene nuclei [2].…”

“…MGN is a quaternary isoquinolone alkaloid, specifically an aporphyrin derivative [2,3]. These compounds are synthesized from benzylisoquinolines in the process of subtraction of two hydrogen atoms, thus creating the 9,10-dihydrophenanthrene structure from two benzene nuclei [2]. The molecular formula of MGN is C2OH24NO4 + with the structural structure shown in Figure 1.…”

“…The molecular formula of MGN is C2OH24NO4 + with the structural structure shown in Figure 1. MGN has two hydroxyl groups (-OH) at positions 1 and 11, two groups (-OCH3) at positions 2, 10 and two methyl groups (-CH3) at positions 6 which are attached to the structure of aporphyrin rings [1,2]. In plants, magnoflorine occurs in the form of a quaternary ammonium ion.…”

“…MGN can be isolated by the LC-MS liquid chromatography method using silica gel (RP-18). Magnoflorine, as a compound containing nitrogen in its structure, is easily detectable in the positive ionization mode by mass spectrometry [2]. Magnoflorine has unique biological properties.…”

“…Magnoflorine has unique biological properties. It has been shown to have antifungal, anticancer, antiviral, antiinflammatory and antioxidant properties [2,6].…”