Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus

Ma, Lishuai; Chen, Hạixia; Peng, Dong; Lu, Xueming

doi:10.1016/j.foodchem.2013.01.030

Cited by 227 publications

(151 citation statements)

References 25 publications

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“…polysaccharides (Dore, et al, 2007;Lu, et al, 2008;Lavi, Levinson, Peri, Hadar, & Schwartz, 2010;Adebayo, Oloke, Majolagbe, Ajani, & Bora, 2012;Ruthes, et al, 2013aRuthes, et al, , 2013bRuthes, et al, , 2013cChang, Lur, Lu, & Cheng, 2013;Castro et al, 2014;Silveira et al, 2014;Silveira et al, 2015), terpenes (Kamo, Asanoma, Shibata, & Hirota, 2003;Yoshikawa et al, 2005;Dudhgaonkar, Thyagarajan, & Sliva, 2009;Ma, Chen, Dong, & Lu, 2013;Tung et al, 2013;Xu, Yan, Bi, Han, Chen, & Wu, 2013;Choi, et al, 2014a), phenolic compounds (Quang, Harinantenaina, Nishizawa, Hashimoto, Kohchi, Soma, & Asakawa, 2006a;Quang et al, 2006bKohno et al, 2008Stanikunaite, Khan, Trappe, & Ross, 2009;Hsieh et al, 2010;Lee, & Huang et al, 2011b;Chen et al, 2013;Taofiq et al, 2015), sterols (Huang, et al, 2010;Ma, Chen, Dong, & Lu, 2013 anti-inflammatory activity of extracts prepared from mushrooms after undergoing some food processing procedures. The results showed reduced activity compared to fresh samples, which implies that anti-inflammatory compounds present in these mushrooms were degraded, e.g due to suseptibility to heating.…”

Section: The Anti-inflammatory Potential Of Mushroom Extractsmentioning

confidence: 99%

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Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

105

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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Section: The Anti-inflammatory Potential Of Mushroom Extractsmentioning

confidence: 99%

“…It is usually associated with the pathogenesis of diseases such as diabetes, arthritis, obesity, metabolic syndrome, cancer and several cardiovascular diseases (Bellik et al, 2012;Moro et al, 2012;Ma, Chen, Dong, & Lu, 2013). …”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

105

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“…The discovery of new molecules from natural origin is a global trend currently for the less toxicity of natural products (Wang et al., 2012). A number of bioactive compounds from natural resources had been investigated, identified, and isolated as inhibitor to various cancer cell lines (Ma, Chen, Dong, & Lu, 2013). In this study, the anticancer activity of water extracts of selected mushrooms was subjected to in vitro cytotoxicity assay in certain cancer cell lines including HT‐29 colon and H‐1299 lungs carcinoma cell lines.…”

Section: Resultsmentioning

confidence: 99%

Anticancer, antithrombotic, antityrosinase, and anti‐α‐glucosidase activities of selected wild and commercial mushrooms from Pakistan

Sharif

Atta

Huma

et al. 2018

Food Science & Nutrition

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Mushrooms have been accepted as nutraceutical foods because of their high nutritional and functional values. They have also gained interest due to their medicinal properties, economic importance, and organoleptic merit. In this study, wild Ganoderma lucidum and four commercial mushrooms, that is, Pleurotus ostreatus, Volvariella volvacea, Hericium erinaceus, and Lentinus edodes from Pakistan were screened for their biological activities such as anticancer, antityrosinase, anti‐α‐glucosidase, and antithrombotic activities from their methanol, ethanol, and water extracts. Enzyme inhibition assay showed that selected mushrooms are potent inhibitors with %age inhibition ranging from 19.00% to 80.91%, and 32.85% to 83.38% for tyrosinase and α‐glucosidase, respectively. The best tyrosinase inhibition was shown by P. ostreatus whereas L. edodes was found best as α‐glucosidase inhibitor. These mushrooms were tested against cancer cell lines including HT‐29 colon and H‐1299 lungs carcinoma cell lines. G. lucidum showed 29% and 24% viability of cells against HT‐29 and H‐1299 cell lines, respectively. This antiproliferative effect was in dose‐dependent manner, and the maximum inhibition was observed at 200 μg/ml. Mushrooms extracts were also found effective against clot lysis. The percentage of clot lysis was in the range of 27%–29%. The research would provide knowledge to the people of Pakistan about the importance of locally available commercial mushrooms and wild mushrooms for health improvement and prevention against different kinds of diseases.

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“…Активные концентрации этих экстрактов составляли в отношении клеток карциномы простаты РС3 29,57±12,18 мкг/мл и 19,22±0,46 мкг/мл, соответственно, а в отношении карциномы молочной железы MDA-MB-231 57,39±14,46 мкг/мл и 46,49±13,21 мкг/мл [36]. Активность петролейного экстракта в отношении обеих линий раковых клеток и активность этилацетатного экстракта против клеток MDA-MB-231 находятся на уровне известного цитостатика -доксорубицина, а против клеток РС3 -в 3 раза ниже по сравнению с доксорубицином [36].…”

Section: Introductionunclassified

“…Например, А, А2, А7, А15 оказали in vitro выраженный гепатопротекторный эффект: 74,8, 81,2, 75,0 и 71,9% соответственно по отношению к контролю -гепатопротектору бициклолу [26]. А1 и А5 проявляют гипогликемические свойства in vitro [55,59], А2, А5 и А24 -противогрибковые свойства in vitro, A1, А2,A5, Б, Б3 -противовоспалительные свойства in vitro [35], А1, А5, А23 -антиоксидантные свойства [36]. А1 и А5 обладают антимутагенным действием, снижают уровень мутагенов MNNG, 4NQO, в Salmonella typhimurium TA98 и TA100 [63].…”

Section: Introductionunclassified

Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga)

2016

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Систематизированы данные по химическому составу веществ тритерпеновой и стероидной природы, выделенных из чаги, как выращенной в условиях искусственной культуры, так и произрастающей в природе. Приведены сведения по биологической активности экстрактов из чаги и этих соединений в отношении различных линий клеток рака in vitro и in vivо. Проведённый анализ позволил выявить определенные закономерности в эффективности подавления роста различных линий клеток. Установлено, что наибольшей активностью обладают тритерпеновые соединения, содержащие ОН-группу при С-22 и ненасыщенную связь в боковой цепи.Ключевые слова: чага, тритерпеновые соединения, стероидные соединения, биологическая активность, in vivo, in vitro DOI 10.18097/PBMC20166204369Рисунок. Общая структурная формула тритерпенов ланостанового ряда (а) и стероидных соединений (б).

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Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus

Cited by 227 publications

References 25 publications

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Anticancer, antithrombotic, antityrosinase, and anti‐α‐glucosidase activities of selected wild and commercial mushrooms from Pakistan

Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga)

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