Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats

Vetal, Sachin; Bodhankar, Subhash L.; Mohan, Vishwaraman; Thakurdesai, Prasad

doi:10.1016/j.fshw.2013.03.003

Cited by 77 publications

(45 citation statements)

References 43 publications

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“…[49,50] Type-A procyanidine polyphenols are reported to have immunomodulatory and anti-inflammatory potential without analgesic activity in both in vitro and in vivo studies. [51] In another study, C. zeylenicum extract was found to reduce inflammation and arthritis in rats by suppressing intracellular release of TNF-α in dose-dependent manner and; hence is an effective remedy for treating RA. [52,53] …”

Section: Guggulosteronementioning

confidence: 97%

Untitled

2017

IJGP

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Rheumatoid arthritis (RA) is a chronic, progressive, sustained inflammatory autoimmune disease associated with articular, extraarticular, and systemic effects. It is characterized by synovial inflammation, hyperplasia, leading to destruction of articular cartilage, bone erosion, and ultimately permanent deformities. Conventional treatments for RA include non-steroidal anti-inflammatory drugs, disease modifying antirheumatoid drugs, corticosteroids, and biological agents. All these therapeutic agents are associated with one or more side-effects, and none of the available treatments are able to achieve the ultimate therapeutic goal, i.e., drug-free remission. Herbal remedies are alternative source to relieve symptoms in patients having RA as well as to overcome the drawbacks associated with present treatment methods. A study conducted by the World Health Organization had reported that about 80% of world's population relies on traditional medicine. More than 450 plants belonging to 100 families are used traditionally in management of arthritis. Some of the important natural compounds reported toexhibit anti-arthritic potential includes anthroquinone (Aloe barbadensis), with anolides (Withania somnifera), terpenes (Zingiber officinale, Boswellia serrata), polyphenols (Camellia sinensis), stilbene (Vitis vinifera, Tripterygium wilfordi). Although a number of herbal medicines are recommended for RA, further research is required to investigate their safety, efficacy, and potential drug interactions.

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Section: Guggulosteronementioning

confidence: 97%

Untitled

2017

IJGP

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“…In this study ethanolic extract was used and anti-inflammatory activity was validated in both in-vitro and in-vivo experiments. [44,45] Muqawwi-e-bah (Aphrodisiac activity)…”

Section: Daf'fe-ta'affun (Antimicrobial Activity)mentioning

confidence: 99%

Description of Darchini (Cinnamomum Zeylanicum) in Unani Medicine: A Review

Shahabuddin¹

2017

WJPR

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“…These results are also in line with reports that anti-inflammatory action of Centipeda minima leaves has been attributed to polyphenolic component. The inhibition of lipid peroxidation, capillary permeability and fragility, and enzymes such as phospholipase A2, cyclooxygenase, and lipoxygenase may be due to tannins and polyphenols components [27].…”

Section: Anti-arthritis Activitymentioning

confidence: 99%

Anti-inflammatory and Anti-arthritis Activity of Flavonoids Fractions Isolated from Centipeda minima Leaves Extracts in Rats

Sarkar¹,

Tripathi²,

Sahu³

2017

Clin Exp Pharmacol

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Centipeda minima has been used since centuries as a traditional medicinal plant in treating a number of disease conditions, the bioactive components responsible for its anti-inflammatory and anti-arthritis activity have not been identified. The present study was planned to isolate flavonoids fractions from Centipeda minima leaves extracts, and assessed anti-inflammatory and anti-arthritis activity in rats. The hydroalcoholic and aqueous extracts of Centipeda minima leaves were prepared and evaluated for in vitro antioxidant activity namely DPPH, total polyphenol content, total flavonol content and reducing power assay. The different fractions were isolated from hydroalcoholic extracts by using column chromatography. The Flavonoids fractions were investigated for anti-inflammatory and anti-arthritis activity in carrageenan rat induced paw oedema, cotton pellet-induced granuloma model and adjuvant induced chronic arthritis in rats. The findings of in vitro antioxidant activity confirmed that hydroalcoholic extracts expressed higher antioxidant activity compared to aqueous extract, and hence hydroalcoholic extracts was further selected for the isolation of various fractions. The results of phytochemical study suggest that FCM6, FCM7 and FCM8 exposed the presence of polyphenol and flavonoids. The fraction FCM6, FCM7 and FCM8 (25 mg/kg) exhibits significant antiinflammatory and anti-arthritis activity. The outcomes suggest that the anti-inflammatory and anti-arthritis activity of isolated fraction was due to presence of flavonoids and polyphenols.

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Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats

Cited by 77 publications

References 43 publications

Untitled

Untitled

Description of Darchini (Cinnamomum Zeylanicum) in Unani Medicine: A Review

Anti-inflammatory and Anti-arthritis Activity of Flavonoids Fractions Isolated from Centipeda minima Leaves Extracts in Rats

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