Anti-Inflammatory Activity of The Extract of Guava Leaves (Psidium guajava L) in The Rat (Rattus norvegicus L)

Abstract

Using of natural sources that have anti-inflammatory activity for the prevention and treatment of degenerative diseases began to be further explored. An investigation on the anti-inflammatory activity of the aqueous extract of guava leaves (Psidium guajava L.) from Sawangan, Depok on white male rats of Sprague-Dawley strain had been carried out on the carrageenan-induced paw edema method. To examine the effect of guava extract on subcutan at different doses of 125, 250 and 500 mg/kg of body weight (BW). Indometacine at dose of 10 mg/kg BW was used as a positive control. Observations were made during five hours with an interval of one hour. These results demonstrate that the percentage of inflammation or edema (% E) optimal at the 4th hour and then decreased at the 5th hour, while the percentage of optimal inhibition occurred at the 5th hour. Guava extract at 125, 250 and 500 mg/kg BW reduced inhibitory percentage activities by 40.81, 55.45 and 43.61% (p< 0.05) respectively. In conclusion, this study suggests that guava extract has anti-inflammatory properties by decreasing edema level.Keywords: Anti-inflammatory, guava leaves, edema.

Psidium guajava leaves decrease arthritic symptoms in adjuvant-induced arthritic rats

“…In a previous study, aqueous extract of P.guajava leaves at a dose of 250 mg/ml had anti-inflammatory activity in male albino rats with arthritis induced by carrageenan. (9) From the results observed in the current investigation, it may be concluded that P. guajava leaves have a potentially in vivo antiarthritic activity, and warrants more in-depth investigations on the mechanism of action of its anti-arthritic activity. In practice, it can be developed as an alternative anti-arthritis drug.…”

“…The aqueous extract of guava leaves at doses of 125, 250, and 500 mg/kg had antiinflammatory activity and decreased edema in rats, with percentage inhibition of 40.81%, 55.45%, and 43.61%, respectively. (9) The Freund's adjuvant model was chosen in this study, as it develops chronic swelling in multiple joints, with influence of inflammatory cells with erosion of joint cartilage and bone destruction. Freund's complete adjuvant-induced arthritis is a well established rat model and has been widely used for many years for evaluation of the anti-inflammatory and anti-arthritic potential of various agents.…”

Phytochemistry and medicinal properties of Psidium guajava L. leaves: A review

“…In contrast to Group-A, downregulation of the arthritis index was also notable in Group-B, Group-C and Group-D. Another research group reported leaves extract decreased inhibitory activity by 40.81 %, 55.45 % and 43.61 % respectively at doses of 125, 250 and 500 mg/kg body weight in carrageenan induced rat paw edema. According to this report, leaf extract has anti-inflammatory properties by reducing edema (62).…”

Psidium guajava: A review on its potential as an adjunct in treating periodontal disease

“…Guava has been known for its anti-inflammatory action. [ 25 43 ] The anti-inflammatory action of guava is in its ability to inhibit prostaglandin, kinin and histamine. [ 44 ] Aa is an important periodontal pathogen and is associated with aggressive periodontitis.…”