Psidium guajava: A review on its potential as an adjunct in treating periodontal disease

Abstract

Plants for thousands of years have been used to enhance health and for medicinal purposes. Psidium guajava is one which has an enormous wealth of medicinal value. It for long has been known for its anti-inflammatory, antimicrobial, antioxidant, antidiarrheal, antimutagenic properties. Despite of its widespread biologic uses there is a dearth of information on its therapeutic effect in the treatment of periodontal disease. Hence, this review is an attempt to highlight the potential of P. guajava in the treatment of periodontal disease. Internet databases PubMed, Google Scholar were searched and the most relevant articles were considered for review.

Comparative evaluation of antimicrobial efficacy of an alternative natural agent for disinfection of toothbrushes

“…[15] In the field of dentistry, its antiplaque, antimicrobial, and anti-inflammatory properties are proven by various authors. [1617]…”

“…in 2011 identified eight flavonoids from guava fresh leaves out of which Guaijaverin has high potential to inhibit the growth of the S. mutans [19] and the most highly abundant flavonoid present is quercetin. [20] The antibacterial action of quercetin is probably due to the disruption of membrane and inactivation of extracellular proteins by forming irreversible complexes and prevents adhesive glucan formation disrupting the initial adhesion[1521] Guaijaverin binds to the cell surface proteins thereby decreasing the hydrophobicity. [15] These flavonoids also interact with microbial membrane proteins, enzymes, and lipids, thereby altering cell permeability and permitting the loss of protons, ions, and macromolecules.…”

“…[20] The antibacterial action of quercetin is probably due to the disruption of membrane and inactivation of extracellular proteins by forming irreversible complexes and prevents adhesive glucan formation disrupting the initial adhesion[1521] Guaijaverin binds to the cell surface proteins thereby decreasing the hydrophobicity. [15] These flavonoids also interact with microbial membrane proteins, enzymes, and lipids, thereby altering cell permeability and permitting the loss of protons, ions, and macromolecules. [21] Tannins can form hydrogen bonds with the protein contained in bacterial cells leading to a conformational change in the protein molecule causing denaturation of proteins.…”

Untitled

“…The two important flavonoids quercetin and guaijaverin are known for their antimicrobial and anti-oxidant effect. Guaijaverin inhibits the growth of streptococcus mutants as it increases hydrophobicity which an important factor for the oral pathogens to adhere to the tooth structure 7 . This inhibit plaque deposit and inhibit the growth of microorganisms without disrupting the homeostatis of the oral cavity.…”

“…This inhibit plaque deposit and inhibit the growth of microorganisms without disrupting the homeostatis of the oral cavity. Quercetin on the other hand disrupts the cell membrane, inactivates the extracellular proteins and form irreversible products 7 . These prove to be bacteriostatic.…”