Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans

Yu, Tao; Ahn, Hyo Min; Shen, Ting; Yoon, Keejung; Jang, Hyun‐Jae; Lee, Yong Jin; Yang, Hyun Mo; Kim, Jae‐Hun; Kim, Changhyuk; Han, Moon Hi; Cha, Sang-hun; Kim, Tae Wong; Kim, Sun Young; Lee, Jaehwi; Cho, Jae Youl

doi:10.1016/j.jep.2011.07.048

Cited by 80 publications

(42 citation statements)

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“…In nature, macrophage plays an important role in response to inflammation via the release of several pro-inflammatory mediators including nitric oxide (NO), prostaglandinE 2 (PGE 2 ) and proinflammatory cytokines (IL-6, TNF-a, IL-1b). These mediators are also produced in many inflamed tissues, enhancing the inflammation-regulatory transcription factors of their mRNAs via the nuclear factor NF-jB pathway [7,8]. Based on this evidence, it is expected that if these substances can exhibit anti-inflammatory activity, they might also provide antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

An Investigation of Antioxidant and Anti-inflammatory Activities from Blood Components of Crocodile (Crocodylus siamensis)

et al. 2014

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Antioxidant and anti-inflammatory activities were found from Crocodylus siamensis (C. siamensis) blood. The 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, nitric oxide scavenging, hydroxyl radical scavenging and linoleic peroxidation assays were used to investigate the antioxidant activities of the crocodile blood. Results show that crocodile blood components had antioxidant activity, especially hemoglobin (40.58 % nitric oxide radical inhibition), crude leukocyte extract (78 % linoleic peroxidation inhibition) and plasma (57.27 % hydroxyl radical inhibition). Additionally, the anti-inflammatory activity of the crocodile blood was studied using murine macrophage (RAW 264.7) as a model. The results show that hemoglobin, crude leukocyte extract and plasma were not toxic to RAW 264.7 cells. Also they showed anti-inflammatory activity by reduced nitric oxide (NO) and interleukin 6 (IL-6) productions from lipopolysaccharide (LPS)-stimulated cells. The NO inhibition percentages of hemoglobin, crude leukocyte extract and plasma were 31.9, 48.24 and 44.27 %, respectively. However, only crude leukocyte extract could inhibit IL-6 production. So, the results of this research directly indicate that hemoglobin, crude leukocyte extract and plasma of C. siamensis blood provide both antioxidant and anti-inflammatory activities, which could be used as a supplementary agent in pharmaceutical products.

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Section: Introductionmentioning

confidence: 99%

An Investigation of Antioxidant and Anti-inflammatory Activities from Blood Components of Crocodile (Crocodylus siamensis)

et al. 2014

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“…Resveratrol, ranitidine, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), pam3CSK, indomethacine (Indo), L-NAME, NSC95397, and lipopolysaccharide (LPS, E. coli 0111:B4) were purchased from Sigma Chemical Co. (St. Louis, MO, USA). The luciferase construct containing the promoter binding site for NF-κB was used as reported previously Yu et al, 2011). Fetal bovine serum (FBS) and RPMI1640 were obtained from Gibco (Grand Island, NY, USA).…”

Section: Methodsmentioning

confidence: 99%

PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities

Hossen

Cho

Kim

2016

Journal of Ethnopharmacology

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“…LY294002 (LY), BAY11-7082 (BAY), U0126, and wortmannin were from Calbiochem (La Jolla, CA, USA). Luciferase constructs containing binding promoters for NF-κB and AP-1 were used as reported previously [12,13] . Enzyme immunoassay (EIA) kits and enzyme-linked immunosorbent assay (ELISA) kits for PGE 2 and TNF-α were purchased from Amersham (Little Chalfont, Buckinghamshire, UK).…”

Section: Methodsmentioning

confidence: 99%

8-(Tosylamino)quinoline inhibits macrophage-mediated inflammation by suppressing NF-κB signaling

et al. 2012

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Aim:The macrophage-mediated inflammatory response may contribute to the development of cancer, diabetes, atherosclerosis and septic shock. This study was to characterize several new compounds to suppress macrophage-mediated inflammation. Methods: Peritoneal macrophages from C57BL/6 male mice and RAW264.7 cells were examined. Anti-inflammatory activity was evaluated in the cells exposed to lipopolysaccharide (LPS). The mechanisms of the anti-inflammatory activity were investigated via measuring transcription factor activation in response to specific signals and via assaying the activities of the target kinases. Results: Of 7 candidate compounds tested, 8-(tosylamino)quinoline (8-TQ, compound 7) exhibited the strongest activities in suppressing the production of NO, TNF-α, and PGE 2 in LPS-activated RAW264.7 cells and peritoneal macrophages (the IC 50 values=1-5 μmol/L). This compound (1.25-20 μmol/L) dose-dependently suppressed the expression of the pro-inflammatory genes for iNOS, COX-2, TNF-α, and the cytokines IL-1β and IL-6 at the level of transcription in LPS-activated RAW264.7 cells. 8-TQ (20 μmol/L) significantly suppressed the activation of NF-κB and its upstream signaling elements, including inhibitor of κB (IκBα), IκBα kinase (IKK) and Akt in LPSactivated RAW264.7 cells. In in vivo experiments, oral administration of 20 and 40 mg/kg 8-TQ for 3 d significantly alleviated the signs of LPS-induced hepatitis and HCl/EtOH-induced gastritis, respectively, in ICR mice. Conclusion: 8-TQ (compound 7) exerts significant anti-inflammatory activity through the inhibition of the Akt/NF-κB pathway, thus may be developed as a novel anti-inflammatory drug.

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Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans

Cited by 80 publications

References 50 publications

An Investigation of Antioxidant and Anti-inflammatory Activities from Blood Components of Crocodile (Crocodylus siamensis)

An Investigation of Antioxidant and Anti-inflammatory Activities from Blood Components of Crocodile (Crocodylus siamensis)

PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities

8-(Tosylamino)quinoline inhibits macrophage-mediated inflammation by suppressing NF-κB signaling

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