Anti‐Cryptococcus activity of combination of extracts of Cassia alata and Ocimum sanctum

Abstract

The paper reports the anti-Cryptococcus activity of combination of ethanolic extracts of leaves of Cassia alata and Ocimum sanctum. The activity of combination of the extracts was heat-stable and worked at acidic pH.

In vitro activity of eugenol, an active component from Ocimum sanctum, against multiresistant and susceptible strains of Neisseria gonorrhoeae

“…Folklore claims that O. sanctum possesses some antiseptic and antimicrobial activity. There are numerous reports regarding the antimicrobial activity of this plant [3]. In our previous study, various extracts of leaves of O. sanctum exhibited considerable activity against N. gonorrhoeae [4].…”

“…In addition, five clinical isolates (1)(2)(3)(4)(5) were used to test the activity during bioassay-guided purification, as some of the purified fractions were not available in sufficient amount to be tested on a larger number of isolates. The activity of the characterised active fraction (H12c) was tested on 14 other isolates (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19).…”

“…The activity of the characterised active fraction (H12c) was tested on 14 other isolates (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Thus, a total of 19 clinical isolates (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) were used in this study, which were isolated from patients with acute gonococcal urethritis and were identified using standard methods [4,5].…”

The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition

“…Cassia alata leaves are also reported to possess anti-inflammatory, antimutagenic, analgesic and antimicrobial properties (Khan et al, 2001;Villasenor et al, 2002;Somchit et al, 2003). Further Cassia alata extract showed anti-cryptococcus activity when used in combination with Ocimum sanctum extract (Ranganathan and Balajee, 2000). Chemical constituents of Cassia alata includes phenolics (chrysaphanol, emodin, rhein, aloe-emodin, kaempferol and their glycosides), fatty acids (palmitic, oleic, linoleic acids), terpenoids (␤-sitosterol, stigmasterol, campesterol) and anthraquinones (alatonal, alatinone) (Khare, 2007;Liu et al, 2009).…”

In vitro Antimalarial Activity of 11 Terpenes Isolated from Ocimum gratissimum and Cassia alata Leaves. Screening of Their Binding Affinity with Haemin

“…Many studies have been reported on the in vitro antimalarial activity of terpenes (Kalauni et al, 2006;Suksarman et al, 2006;Chukwejeku et al, 2005), on biological activities of Ocimum gratissimum essential oil (Ueda-Nakamura et al, 2006;Tchoumbougnang et al, 2005;Usip et al, 2006) and on antimicrobial activity of aqueous and ethanol extracts of Cassia alata (Somchit et al, 2003;Villasenor et al, 2002;Ranganathan et al, 2000).…”