In vitro activity of eugenol, an active component from Ocimum sanctum, against multiresistant and susceptible strains of Neisseria gonorrhoeae

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

“…For example, the activities of many of these have not been examined against XDR or MDR gonococcal isolates, particularly those with ESC resistance or high-level azithromycin resistance. Furthermore, despite the fact that a breakthrough is lacking, as part of "thinking outside the box," it can be important to continuously evaluate appropriate plant extracts for in vitro activity against gonococci and, subsequently, for treatment of gonorrhea (136,(333)(334)(335)(336)(337)(338)(339)(340)(341)(342)(343)(344)(345). All novel potential treatment regimens for gonorrhea require up-to-date and comprehensive in vitro and, subsequently, in vivo evaluations, including appropriately designed, randomized, and controlled clinical trials to evaluate parameters such as efficacy, safety, toxicity, cost, optimal dose, and pharmacokinetic/pharmacodynamic data for genital and extragenital (especially pharyngeal) gonorrhea.…”

Preparation and Characterization of Hydroxypropyl-.BETA.-Cyclodextrin Inclusion Complex of Eugenol: Differential Pulse Voltammetry and 1H-NMR

“…Essential oils and their components exhibit myriad medicinal properties including antimicrobial (antibacterial and antifungal), analgesic and antioxidant activity. [1][2][3] Antimicrobial properties of the essential oils have been recognized and used since ancient times for food preservation as well as for medicinal purpose because of their antimicrobial and antifungal effects. The antifungal effect of essential oils (EO) has been noted in several studies.…”

“…Study of electrochemical behavior of Eugenol after formation of inclusion complex is very important as oxidant effect of Eugenol is responsible for most of the medicinal properties of Eugenol such as anti-microbial activity. 2) Cyclodextrin complexation could result in loss of pharmacological activity of compound. 22) Therefore, in the present work electrochemical behaviour of Eugenol was determined by using DPV.…”

Anti-microbial Activity of Tulsi { Ocimum Sanctum (Linn.) } Extract on a Periodontal Pathogen in Human Dental Plaque: An Invitro Study

“…Hence, there is a need to come up with an alternative and [7]. Tulsi has demonstrated anti-gonorrheal efficacy against multiresistant strains of Neisseria gonorrhoea and clinical isolates of beta-lactamase producing methicillin resistant Staphylococcus aureus [8].…”