Anti-
            <i>Candida</i>
            Activity of a New Platinum Derivative

Watanabe, Toshihiko; Takano, Misako; Ogasawara, Ayako; Mikami, Takeshi; Kobayashi, Takao; Watabe, Masatoshi; Matsumoto, Tatsuji

doi:10.1128/aac.44.10.2853-2854.2000

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…The α,β-unsaturated carbonyl compounds 1 – 12 were prepared using a previously reported methodology (Scheme 2) [15]. These compounds were used as starting materials for the synthesis of the target products 15 – 38 (Scheme 2) of varied structures ( 15 – 38 ) that were obtained in good yields, as shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…General scheme for the synthesis of new N -phenyl and N -4-chlorophenylpyrazolines 15 – 38 (methodology previously described in full in [15]).…”

Section: Figures Schemes and Tablesmentioning

confidence: 99%

“…The synthesized compound were tested against an ample panel of cancer cell lines within the Developmental Therapeutics Program (DTP) at the National Cancer Institute (NCI) due to the fact that the moiety 2-pyrazoline [11,12] has demonstrated antitumor activities. Furthermore, considering that several antineoplastic compounds have proven valuable antifungal activities [14,15], we tested them as antifungals against two clinically important fungi, Candida albicans and Cryptococcus neoformans . It is important to take into account the limited number of efficacious antifungal drugs, which are not completely effective for the eradication of mycoses.…”

Section: Introductionmentioning

confidence: 99%

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Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity

et al. 2016

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Twenty-four new hybrid analogues (15-38) containing 7-chloro-4-aminoquinoline and 2-pyrazoline N-heterocyclic fragments were synthesized. Twelve of the new compounds were evaluated against 58 human cancer cell lines by the U.S. National Cancer Institute (NCI). Compounds 25, 30, 31, 36, and 37 showed significant cytostatic activity, with the most outstanding GI 50 values ranging from 0.05 to 0.95 µM. The hybrid compounds (15-38) were also evaluated for antifungal activity against Candida albicans and Cryptococcus neoformans. From the obtained results some structure-activity relationships were outlined.

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Section: Resultsmentioning

confidence: 99%

“…General scheme for the synthesis of new N -phenyl and N -4-chlorophenylpyrazolines 15 – 38 (methodology previously described in full in [15]).…”

Section: Figures Schemes and Tablesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity

et al. 2016

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“…Many antineoplastic agents bind to fungal homologues of their human cell targets. Cisplatin has demonstrated antiCandida activity, possibly related to DNA breakage or cell wall toxicity [15]. However, the concentration of cisplatin necessary to achieve fungal toxicity as a single agent may not be achievable in vivo.…”

Section: Antineoplastic Agentsmentioning

confidence: 99%

Antifungal activity of nontraditional antifungal agents

Judd

Martin

2009

Curr Fungal Infect Rep

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“…Recent screening studies using disk diffusion have shown that cis-diamminedichloro platinum (Cisplatin), a well-established antitumor agent, inhibits the growth of C. alibcans at lower concentrations [6]. Despite its prevalent use in cancer treatment, very little work has been done [7-10] to document the effects of Cisplatin and related metal complexes in controlling the proliferation behavior of C. alibcans . With the molecular mechanisms remaining largely unknown, this provided us a basis to study the effects of Cisplatin treatment on the morphology and growth curve of C. alibcans .…”

Section: Introductionmentioning

confidence: 99%

Morphological and growth altering effects of Cisplatin in C. albicans using fluorescence microscopy

Kesavan

Malathi²,

Ganesan

2005

Ann Clin Microbiol Antimicrob

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Changes in morphology and growth curve of Candida albicans in response to treatment by Cisplatin has been studied using fluorescence staining with ethidium bromide. Treatment with Cisplatin was found to markedly inhibit hyphae and ovoid growth as revealed by ethidium bromide staining of drug treated cells. These changes were concomitant with inhibitory effects on the growth curve with respect to untreated cellsPresence of Cisplatin not only caused suppression in the limiting values in the growth curve, but also caused a slight left shift in the EC50 values. Some of the ovoid cells undergoing poisoning with cisplatin were found to be unusually enlarged before undergoing their natural fate thus suggesting formation of similar cytotoxic end products with DNA.

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Anti- Candida Activity of a New Platinum Derivative

Cited by 7 publications

References 14 publications

Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity

Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity

Antifungal activity of nontraditional antifungal agents

Morphological and growth altering effects of Cisplatin in C. albicans using fluorescence microscopy

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