Antifungal activity of nontraditional antifungal agents

Judd, William R.; Martin, Craig A.

doi:10.1007/s12281-009-0012-z

Cited by 6 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antifungal properties of anesthetics had already been presented in previous works (Judd & Martin, 2009;Wright, Durieux, & Groves, 2008).…”

Section: Resultsmentioning

confidence: 89%

“…already show reduced sensitivity to this drug (Liu, Fan, Peng, & Zhang, 2014;Sobel, 2013). Lidocaine (LD) is an anesthetic used in clinical medicine, which showed antifungal activity has already been described, alone or in synergy with antifungal agents like amphotericinB, itraconazole, voriconazole, and caspofungin, however it is important to emphasize that the use must be topical due to toxicity (Judd & Martin, 2009;Palmeira-deOliveira et al, 2012;Rodrigues, Araujo, & Pina-Vaz, 2006).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro synergistic activity of lidocaine and miconazole against Candida albicans

Cunha¹,

Filho²,

Cunha³

et al. 2017

Acta Sci. Health Sci.

View full text Add to dashboard Cite

ABSTRACT. Candida albicans is the main yeast isolated from vulvovaginal candidiasis(VVC) and a major antifungal used to treat VVC is miconazole (MZ), it shows local toxic effects, such as irritation and burns. The lidocaine (LD) is a local anesthetic. The aim of this study was to evaluate the synergistic activity of LD/MZ against 19 strains of C. albicans isolated from vaginal secretion. 78.9% of the strains were susceptible to the combination LD/MZ, demonstrating synergism of drugs. These drugs can be used to produce vaginal creams to treat VVC, especially drug resistant.Keywords: vulvovaginal candidiasis, antifungal agents, local anesthetic.Atividade sinérgica in vitro de lidocaína e miconazole contra Candida albicans RESUMO. Candida albicans é a principal levedura isolada de candidíase vulvovaginal (CVV) e o principal antifúngico usado para tratar a VVC é miconazol (MZ), que apresenta efeitos tóxicos locais, tais como irritação e queimaduras. A lidocaína (LD) é um anestésico local. O objetivo deste estudo foi avaliar a atividade sinérgica de LD/MZ contra 19 cepas de C. albicans isoladas de secreção vaginal. Foram suscetíveis à combinação LD/MZ, 78.9% das cepas testadas, demonstrando sinergismo de drogas. Estes fármacos podem ser utilizados para a produção de cremes vaginais para tratar VVC, especialmente aquelas resistentes aos fármacos disponíveis.Palavras-chave: candidíase vulvovaginal, agentes antifúngicos, anestésico local.

show abstract

“…The antifungal properties of anesthetics had already been presented in previous works (Judd & Martin, 2009;Wright, Durieux, & Groves, 2008).…”

Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

In vitro synergistic activity of lidocaine and miconazole against Candida albicans

Cunha¹,

Filho²,

Cunha³

et al. 2017

Acta Sci. Health Sci.

View full text Add to dashboard Cite

show abstract

“…The in vitro broad-spectrum activity of non-antifungal compounds against human pathogenic fungi was published earlier (Judd and Martin 2009). Testing the activity of phenothiazines such as chlorpromazine and trifluoperazine against medically important yeasts such as C. neoformans proved that it is one of the most susceptible species (Eilam et al 1987).…”

Section: Discussionmentioning

confidence: 99%

In vitro interactions of amphotericin B and non-antifungal compounds against opportunistic human pathogen Cryptococcus neoformans

Szerencsés¹,

Mülbacher²,

Vágvölgyi³

et al. 2020

Acta Biol Szeged

View full text Add to dashboard Cite

The incidence of opportunistic human pathogen Cryptococcus neoformans caused infections have been higher during the last few decades along with the increasing number of susceptible individuals around the world. Recommended treatment of cryptococcal meningoencephalitis is a combined therapy with amphotericin B deoxycholate and flucytosine. Despite of the efficiency of this drug combination, the mortality rate of the disease is high due to the limited accessibility and the high cost of these antifungals in the most severely affected areas. The broad-spectrum activity of non-antifungal drugs and their potential to enhance the efficiency of conventional antifungal agents have been recognised previously. In this study, the in vitro activity of amantadine, valproic acid, trifluoperazine and chlorpromazine was tested against five C. neoformans strains individually and in combination with amphotericin B. All the four compounds exerted slight antifungal activity against the studied C. neoformans strains. Their combination with amphotericin B revealed additive and synergistic interactions.

show abstract

“…Initiation of antifungal therapy prior to obtaining blood or CSF samples may result in false‐negative culture results. Previous studies have examined the antifungal properties of antineoplastics and other non‐traditional antifungal agents . Flucytosine is used in combination with amphotericin‐B as induction therapy for Cryptococcal meningitis .…”

Section: What Is Known and Objectivementioning

confidence: 99%

“…Previous studies have examined the antifungal properties of antineoplastics and other non-traditional antifungal agents. [3][4][5] Flucytosine is used in combination with amphotericin-B as induction therapy for Cryptococcal meningitis. 6 Fungal DNA and protein synthesis are inhibited by the active metabolite, 5-fluorouracil (5-FU).…”

Section: What Is Known and Objectivementioning

confidence: 99%

False-negative cerebrospinal fluid fungal culture results following oral antineoplastic therapy with a 5-fluorouracil derivative

et al. 2015

View full text Add to dashboard Cite

show abstract

Antifungal activity of nontraditional antifungal agents

Cited by 6 publications

References 53 publications

<b><i>In vitro</i> synergistic activity of lidocaine and miconazole against <i>Candida albicans

<b><i>In vitro</i> synergistic activity of lidocaine and miconazole against <i>Candida albicans

In vitro interactions of amphotericin B and non-antifungal compounds against opportunistic human pathogen Cryptococcus neoformans

False-negative cerebrospinal fluid fungal culture results following oral antineoplastic therapy with a 5-fluorouracil derivative

Contact Info

Product

Resources

About