Anti-hypertensive activity of aqueous and methanolic leaf extracts of Schleichera oleosa (Lour.) Merr

Abstract

Nitric oxide radical scavenging activityNOSA was performed as per previous method of Kumar et al.,11 10μg, 50μg and 100μg concentrations of aqueous and methanolic plant extract and Butylated hydroxy anisole (BHA) were taken in different test tubes and made up to 3ml with 0.1M phosphate buffer J Anal Pharm Res. 2019;8(3):94-97. 94 AbstractPresent study was undertaken to investigate phytochemical, nitric oxide scavenging activity and antihypertensive activity of the methanolic and aqueous leaf extracts of S. oleosa. The phytochemical analysis carried out revealed the presence of flavanoids, glycosides, alkaloids, tannins, saponins and steroids and many other metabolites. Both the extracts showed high NOSA (33.81% and 31.43% NOSA at 100µg concentration). The methanolic leaf extract showed 1.6%, 4%, and 5.6% ACE inhibition against 10µg, 50µg and 100µg concentration respectively and aqueous leaf extract of S. oleosa showed very negligible percentage that is 0%, 0% and 0.8% ACE inhibition against 10µg, 50µg and 100µg extract concentration respectively while Captopril showed 100% ACE inhibition against all the three concentrations. The result shows that the methanolic as well as the aqueous leaf extracts of Schleichera oleosa are not very good antihypertensive agents. However the methanolic leaf extract of Schleichera oleosa is a better antihypertensive inhibitor than the aqueous leaf extract.