Anti-hyperglycemic and liver protective effects of flavonoids from Psidium guajava L. (guava) leaf in diabetic mice

Zhu, Xiaoai; Ouyang, Wen; Lan, Yaqi; Xiao, Hang; Tang, Lan; Guo, Lei; Feng, Konglong; Zhang, Liqun; Song, Mingyue; Cao, Yong

doi:10.1016/j.fbio.2020.100574

Cited by 44 publications

(25 citation statements)

References 31 publications

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“…Flavonoids and polysaccharides of GLs have been reported for their antidiabetic potential in several studies. Guaijaverin and avicularin flavonoids of GL extract were associated with significant improvement in the function of β-cells of pancreatic islets and hepatocyte morphology in diabetic mice [ 57 ]. Guaijaverin suppressed the activity of the blood glucose homeostasis enzyme dipeptidyl-peptidase IV [ 58 ], while avicularin inhibited intracellular lipid aggregation by impeding glucose uptake through GLUT-4 in vitro and revealed no distinct toxicity for 3T3-L1 adipose cells [ 59 ].…”

Section: Biological Activities Of Guava Leaf Extractsmentioning

confidence: 99%

Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities

Kumar

Tomar

Amarowicz

et al. 2021

Foods

162

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Psidium guajava (L.) belongs to the Myrtaceae family and it is an important fruit in tropical areas like India, Indonesia, Pakistan, Bangladesh, and South America. The leaves of the guava plant have been studied for their health benefits which are attributed to their plethora of phytochemicals, such as quercetin, avicularin, apigenin, guaijaverin, kaempferol, hyperin, myricetin, gallic acid, catechin, epicatechin, chlorogenic acid, epigallocatechin gallate, and caffeic acid. Extracts from guava leaves (GLs) have been studied for their biological activities, including anticancer, antidiabetic, antioxidant, antidiarrheal, antimicrobial, lipid-lowering, and hepatoprotection activities. In the present review, we comprehensively present the nutritional profile and phytochemical profile of GLs. Further, various bioactivities of the GL extracts are also discussed critically. Considering the phytochemical profile and beneficial effects of GLs, they can potentially be used as an ingredient in the development of functional foods and pharmaceuticals. More detailed clinical trials need to be conducted to establish the efficacy of the GL extracts.

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Section: Biological Activities Of Guava Leaf Extractsmentioning

confidence: 99%

Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities

Kumar

Tomar

Amarowicz

et al. 2021

Foods

162

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“…Guava ( Psidium guajava L.), known as a tropical fruit, has numerous commercial applications owing to its taste, flavor and aroma. It contains a broad spectrum of phytochemicals, including polysaccharides, alkaloids, glycosides, vitamins (it contains four times more vitamin C than citrus), essential oils, minerals, enzymes, proteins [ 4 ], flavonoids [ 5 ], tannins, and saponins [ 6 ]. Various pharmacological uses have been reported from its parts, such as the antiseptic effect of leaves, fresh fruit and tea from leaves in order to treat diarrhea, dysentery, diabetes mellitus and others [ 4 , 5 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Various pharmacological uses have been reported from its parts, such as the antiseptic effect of leaves, fresh fruit and tea from leaves in order to treat diarrhea, dysentery, diabetes mellitus and others [ 4 , 5 , 7 ]. The leaves (having phenolic compounds) and bark of the P. guajava tree have an extensive history of medicinal uses that are still active today [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Bioactive compounds from plant sources, especially polyphenols have been proposed to affect the glucose metabolism. Polyphenols play an important role in the control of diabetes by inhibiting the absorption of glucose from small intestine, enhancing the secretion of insulin and the controlled release of glucose from liver [ 6 ]. Among these, flavonoids are responsible for their therapeutic activities; much of a guava’s therapeutic activity and antibacterial activity have been attributed to these flavonoid compounds [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Screening and Antidiabetic Potential of Polyphenol Extracts from Guava Pulp, Seeds and Leaves

Shabbir

Kausar

Noreen

et al. 2020

Animals

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The present study investigates the antidiabetic potential of polyphenol extracts purified from guava pulp, seeds and leaves using an in vivo experiment on albino rats. The polyphenols from guava pulp, seeds and leaves were extracted using methanol solvent and the sonication method while being evaluated by total phenolic contents and radical scavenging activity assay. The proximate composition of powders revealed that ash, protein and total sugars were significantly (p < 0.05) higher in leaves and seeds, while vitamin C was highest in pulp. Total phenolic and antioxidant activities were highest in pulp followed by leaves and seeds. The findings of feed intake and body gain revealed that the supplementation of polyphenols, especially from pulp, significantly (p < 0.05) increased the feed intake, which resulted in increased body weight. Moreover, total cholesterol (TC) and low-density lipoprotein (LDL) levels were significantly (p < 0.05) decreased, while the level of high-density lipoprotein (HDL) was increased in groups fed with polyphenols from guava pulp compared to both (+ive and –ive) control groups. Furthermore, blood glucose and triglycerides were significantly (p < 0.05) decreased in supplemented groups compared to the control group of diabetes mice, which resulted in the inhibition of α-amylase and glucose transport. Besides this, packed cell volume (PCV), mean corpuscular volume (MCV), hemoglobin, red blood cells (RBCs), white blood cells (WBCs) and platelet levels were increased significantly (p < 0.05) in pulp’s extract followed by leaves and seeds compared to both control groups. Overall, the antidiabetic potential of different extracts was in the following order: pulp > leaves > seeds. The findings suggest the feasibility of adding 200–250 mg/kg.bw of polyphenol extracts of pulp as an alternative to diabetic drugs.

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“…The potent inhibitory effect of the α-amylase may be in uenced by the abundance of phenolic compounds in MEAE. It has been reported in the literature that Ephedra alata alcohol extract contain bioactive principle that may be useful in the management or prevention of diabetic complications [29,30]. In fact, The LC-DAD-ESI/MSn pro le of E. alata was characterized by the presence of various phenolic compounds, all belonging to avonoids class, namely ve iso avones the diazein, the Epicatechin, the rutin as well as the quercitin and avones;…”

Section: Discussionmentioning

confidence: 99%

Ephedra alata extracts exhibits anti-obesity, anti-hyperlipidaemic, anti-hyperglycemia, anti-antipyretic and analgesic effects through the inhibition of lipase, α-amylase and inflammation

Tiss¹,

Souiy²,

Boujbiha³

et al. 2020

Preprint

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In this present study, phytochemical screening, anti-obesity, anti- antipyretic and analgesic effect of Ephedra alata (EA) extracts were evaluated. Results of this study showed that the methanol EA extract (MEAE) had a stronger inhibition activity on key enzyme related to obesity as lipase (IC50 = 1.296 mg/ml) as compared to water and ethyl acetate extracts ( with IC50 = 1.639 and 1.897 respectively). Also results revealed that ethyl acetate extract depicted high activity toward key enzyme related to hyperglycemia as α-amylase (IC50 = 0.284 mg/mL) while water and methanol extracts showed good to moderate inhibitory activity (IC50 = 1,525 and 1,103 mg/ml respectively). In HFFD rats, the administration of MEAE at 200 mg/kg inhibited key enzyme related to fat digestion and absorption as lipase in the intestine, pancreas and serum by 53, 40 and 53% respectively,which leads to decrease in body weight by 20% and also modulation of lipid profile. In addition, the administration of MEAE to HFFD-rats exerts an inhibitory effect on α-amylase activity in the intestine, pancreas and serum by 43, 26 and 46% respectively and this leads to decrease in blood glucose level by 35%. Also, MEAE exert antipyretic and analgesic activities. This study demonstrates for the first time that MEAE are efficient in preventing obesity and hyperglycemia and liver toxicity. This data generated during study shows antipyretic and analgesic activities of MEAE.

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Anti-hyperglycemic and liver protective effects of flavonoids from Psidium guajava L. (guava) leaf in diabetic mice

Cited by 44 publications

References 31 publications

Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities

Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities

In Vivo Screening and Antidiabetic Potential of Polyphenol Extracts from Guava Pulp, Seeds and Leaves

Ephedra alata extracts exhibits anti-obesity, anti-hyperlipidaemic, anti-hyperglycemia, anti-antipyretic and analgesic effects through the inhibition of lipase, α-amylase and inflammation

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