Anti-HIV activity of methanolic and aqueous extracts of fifteen materials of beach-cast macroalgae: valorization of underused waste biomass

Harb, Talissa Barroco; Chow, Fungyi

doi:10.1080/26388081.2021.1986677

Cited by 4 publications

(2 citation statements)

References 50 publications

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“…All three seaweed extracts showed antioxidant activity, while only hot aqueous extracts from S. vulgare showed the highest anti-HIV potential. The recent study of Harb et al [133] evaluated the potential of beach-cast seaweed methanolic and aqueous extracts to inhibit the reverse transcriptase enzyme of the HIV-1. In general, the aqueous extracts showed higher RT inhibition potential as an antiviral agent than methanolic extracts.…”

Section: Anti-hiv Activity Of Seaweedsmentioning

confidence: 99%

“…Broad antiviral spectrum [113,[156][157][158] In vitro/in vivo inhibition of virus replication [115,122,124] Enhanced antibody production and immunomodulation activity [127,165,189,190] Anti-inflammatory activity [167] Prevention of the virus entry into the host cell [126,131,149] RT inhibition potential [132][133][134]136] No cytotoxicity effect [128,143,147,149] Compounds can be included in prophylaxis treatments [131,148,169] Cons Antiviral activity depends on the chemical structure (e.g., low antiviral activity is given by low number of sulphated groups) [70,80,[98][99][100]142] Strong anticoagulant activity of carrageenan could provoke adverse reaction in antiviral treatments [97,126,175,186,187] Antiviral activity is influenced by extraction methods [133,134] Poor adherence/non-frequent use of seaweed-based treatment decreases antiviral activity [173] The use of natural compounds as a replacement for synthetic ones or in combination with pre-existing antiviral treatments could be a way to optimize the production cost of drugs, to reduce side effects in patients as seaweed's comp...…”

Section: Prosmentioning

confidence: 99%

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Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Lomartire

Gonçalves

2022

Marine Drugs

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In the last decades, the interest in seaweed has significantly increased. Bioactive compounds from seaweed’s currently receive major attention from pharmaceutical companies as they express several interesting biological activities which are beneficial for humans. The structural diversity of seaweed metabolites provides diverse biological activities which are expressed through diverse mechanisms of actions. This review mainly focuses on the antiviral activity of seaweed’s extracts, highlighting the mechanisms of actions of some seaweed molecules against infection caused by different types of enveloped viruses: influenza, Lentivirus (HIV-1), Herpes viruses, and coronaviruses. Seaweed metabolites with antiviral properties can act trough different pathways by increasing the host’s defense system or through targeting and blocking virus replication before it enters host cells. Several studies have already established the large antiviral spectrum of seaweed’s bioactive compounds. Throughout this review, antiviral mechanisms and medical applications of seaweed’s bioactive compounds are analyzed, suggesting seaweed’s potential source of antiviral compounds for the formulation of novel and natural antiviral drugs.

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Section: Anti-hiv Activity Of Seaweedsmentioning

confidence: 99%

Section: Prosmentioning

confidence: 99%

Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Lomartire

Gonçalves

2022

Marine Drugs

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Brazilian Beach-Cast Seaweeds: Antioxidant, Photoprotection and Cytotoxicity Properties

Harb

Vega

Bonomi-Barufi

et al. 2022

Waste Biomass Valor

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The potential of seaweed extracts in cosmetic applications have increased with novel development and market. Beneficial biological properties include the ability to struggle aging and anticancer agents. This research aimed to evaluate antioxidant, photoprotective and cytotoxic properties of extracts from beach-cast seaweed species from the Brazilian coast in order to propose an appropriate use of this sustainable resource. Analysis of antioxidant capacity, UV/VIS absorption, quantification of UV photoprotectors, total content of C, N and S, development of cosmetic creams and evaluation of the cytotoxicity activity against tumoral cells lines were performed. The highest antioxidant capacity was found in extracts of brown seaweeds, followed by red seaweeds, with the lowest activity detected in the green seaweed. Same pattern was observed for phenolic compounds. The extracts did not show cytotoxicity activity against healthy human cells. Other forms of extraction and incorporation of the extract into the base creams should be evaluated, the isolation and purification of substances could increase the efficiency of the photoprotective capacity. The species were highly promising and proved to be natural sources of antioxidants and substances with cytotoxicity activity against tumoral cells; therefore, they could be exploited as functional ingredients with specific applications for different types of industries. The application of seaweed extracts in combination with other natural ingredients can help in the design of new cosmetics against the negative effects of UV radiation, in addition to having the great advantage of not presenting toxicity to health or the environment because they are biodegradable. Graphical Abstract

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A Review on Seaweeds and Seaweed-Derived Polysaccharides: Nutrition, Chemistry, Bioactivities, and Applications

Xie

Lee

et al. 2023

Food Reviews International

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Anti-HIV activity of methanolic and aqueous extracts of fifteen materials of beach-cast macroalgae: valorization of underused waste biomass

Cited by 4 publications

References 50 publications

Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Brazilian Beach-Cast Seaweeds: Antioxidant, Photoprotection and Cytotoxicity Properties

A Review on Seaweeds and Seaweed-Derived Polysaccharides: Nutrition, Chemistry, Bioactivities, and Applications

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