Anti-hepatitis B virus lignans from the root of Streblus asper

Li, Jun; AiPing, Meng; Guan, Xin-Lan; Li, Jian; Wu, Qiang; Deng, Shengping; Xiao-jian, SU; Yang, Ronghua

doi:10.1016/j.bmcl.2013.01.046

Cited by 42 publications

(22 citation statements)

References 28 publications

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“…(7′R,8′S,7′′R,8′′S)-erythro-strebluslignanol G, a neolignan and also a dimer of strebluslignanols, was isolated from the root of Streblus asper. It exhibits significant anti-HBV activities in the secretion of HBsAg and HBeAg, with IC50 values of 3.67 and 14.67 µM, respectively [90].…”

Section: Neolignansmentioning

confidence: 99%

Lignans and Their Derivatives from Plants as Antivirals

et al. 2020

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Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans-podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals-are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.

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Section: Neolignansmentioning

confidence: 99%

Lignans and Their Derivatives from Plants as Antivirals

et al. 2020

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“…To identify the active constituents, compounds (3)(4)(5)(6)(7)(8) from the EtOAc fraction were investigated for anti-melanogenic effects, with arbutin as positive control. The cytotoxic activities of these compounds against B16F10 cells were also determined by MTT assays.…”

Section: Melanogenesis-inhibitory Activities Of Compoundsmentioning

confidence: 99%

“…1 In current pharmacologic research, S. asper has exhibited antilarial, 3,4 antimicrobial, 5 antimalarial, 6 anti-HBV, 7,8 antidiabetic, 9 cytotoxic, and antineoplastic activities. [10][11][12] The chemical constituents of S. asper including avo-noids, 7,13 volatile oils, 14 phenolic acids, 4 fatty acids, 15 phenylpropanoids, 7,8,16,17 and cardiac glycosides [18][19][20][21] have been extensively studied. Numerous cardiac glycosides have also been discovered from the roots of this plant.…”

Section: Introductionmentioning

confidence: 99%

“…Bufalin is a cardiac aglycone, which belongs to bufanolide, and it can stimulate melanin synthesis in B16F10. 22 Thus, cardiac glycosides (3)(4)(5)(6)(7)(8) having aglycones belonging to cardenolides were selected for the evaluation of their ability to stimulate melanin synthesis in a-melanocyte (a-MSH)-stimulated B16F10 cells. It was interesting that 3-8 showed melanogenesis-inhibitory abilities.…”

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confidence: 99%

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Three new cardiac glycosides obtained from the roots ofStreblus asperLour. and their cytotoxic and melanogenesis-inhibitory activities

Miao

Zhang

et al. 2018

RSC Adv.

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Three new cardiac glycosides strophanthidin-3-O-a-L-rhamnopyranosyl-(1/4)-6-deoxy-b-Dallopyranoside (1), 5bH-16b-acetylkamaloside (2), and mansonin-19-carboxylic acid (3) along with seven known steroids including five cardiac glycosides were isolated from the methanol extracts of Streblus asper Lour. roots. The structures of these compounds were established by spectroscopic analyses. The cytotoxicities of crude extracts and all the isolated compounds were evaluated against four human cancer cell lines (HL60, A549, AZ521, and SKBR3). Furthermore, the selective index (SI) of each compound was measured by the ratio of cytotoxic effect on a normal cell line (WI38) to the cytotoxic effect on cancer cell line (A549). The results suggested that cardiac glycosides (2, 4, and 6-8) exhibited significant cytotoxicities with IC 50 values from 0.01 to 3.77 mM as well as high selective index for WI38/ A549 (SI 1.50-24.26), and they displayed superior selectivities when compared with the reference cisplatin (SI 1.09). Preliminary structure-activity relationships (SARs) were also discussed regarding the type of C-10 group in the cardiac glycosides being a crucial factor in determining the cytotoxic activities and regarding the sugar moieties having much less of an active role than the type of C-10 group. In addition, the melanogenesis-inhibitory abilities of these compounds were also evaluated. Cardiac

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“…It is used as an antibacterial agent and for the treatment of HBV infection, fever, dysentery, toothache, gingivitis, inflammation, etc . This plant is known to produce steroids, cardiac glycosides, flavonoids, triterpenoids and lignans …”

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confidence: 99%