Anti-fatigue and vasoprotective effects of quercetin-3-O-gentiobiose on oxidative stress and vascular endothelial dysfunction induced by endurance swimming in rats

Lin, Yin Shiou; Liu, Hua-Liang; Fang, Jie; Yu, Chunjing; Yao-kang, Xiong; Yuan, Ke

doi:10.1016/j.fct.2014.03.026

Cited by 71 publications

(65 citation statements)

References 58 publications

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“…Glycogen is one of the storage forms of energy in the living body. During strenuous exercise, the capability of glycogen storage prior to exercise can directly affect the ability to exercise (27). However, in the current study, no significant difference was observed between the control and DSW-treated groups.…”

Section: Groupcontrasting

confidence: 49%

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Fan¹,

Tan²,

Yue³

et al. 2016

Biomedical Reports

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Abstract. Physical fatigue is extremely common and occurs daily, and is considered to be associated with oxidative stress. The diverse functions of deep sea water (DSW) have recently gained increasing attention. Previous studies have emphasized the anti-fatigue effect of DSW, but the intrinsic mechanism behind the effect remains to be elucidated. In the imprinting control region (ICR) mice model, DSW delayed the exhaustive swimming time. In addition, DSW decreased the area under the blood lactate (BLA) curve, which was associated with the area under the BLA curve of pre-swimming, post-swimming and post-rest. Furthermore, DSW reduced the basal levels of malondialdehyde and the post-swimming concentration of blood urea nitrogen, lactate dehydrogenase and creatine kinase after swimming, along with an increase in the normal level of antioxidant enzyme activity such as superoxide dismutase and glutathione peroxidase. However, no significant effect on body weight, hepatic glycogen and muscle glycogen was observed between any group. In conclusion, DSW can improve the athletic ability and alleviate physical fatigue of ICR mice. This effect is achieved by enhancing the antioxidant capacity.

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Section: Groupcontrasting

confidence: 49%

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Fan¹,

Tan²,

Yue³

et al. 2016

Biomedical Reports

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“…An exhaustive swim‐training model used in this study was employed as previously reported, with minor modications. Briefly, each of the rats in all the groups except the NC group was forced to swim with a lead block (weighing about 5% of the body weight) attached to its tail.…”

Section: Methodsmentioning

confidence: 96%

Anti‐fatigue activity of sea cucumber peptides prepared from Stichopus japonicus in an endurance swimming rat model

Shen

Huang

et al. 2017

J Sci Food Agric

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“…Flavonoids from plants are considered to be one of the most effective groups of phytochemicals due to their wide range of pharmacological activities, such as antioxidative, anti-inflammatory, immunomodulatory, antidiabetic, and antitumor effects [15–18]. Flavonoids have also been widely studied as a new group of natural antifatigue substances; many studies have revealed that flavonoid supplementation enhanced the endurance exercise performance of fatigued rats by reducing their muscle fatigue [19, 20]. …”

Section: Introductionmentioning

confidence: 99%

Antifatigue Effect of Luteolin‐6‐C‐Neohesperidoside on Oxidative Stress Injury Induced by Forced Swimming of Rats through Modulation of Nrf2/ARE Signaling Pathways

Duan

Guo

et al. 2017

Oxidative Medicine and Cellular Longevity

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Luteolin-6-C-neohesperidoside (LN) is a flavonoid isolated from moso bamboo leaf. This study was performed to evaluate the antifatigue effect of LN on a rat model undergoing the weight-loaded forced swimming test (FST). Briefly, male Sprague-Dawley rats (20–22 weeks old) were forced to undertake exhaustive swimming every other day for 3 weeks. Each swimming session was followed by the administration of distilled water, LN (25–75 mg/kg), or ascorbic acid (100 mg/kg) 1 h later. Oral administration of LN significantly improved exercise endurance; normalized alterations in energy metabolic markers; and decreased serum lactic acid, lactate dehydrogenase, and blood urea nitrogen levels of rats that underwent FST. Moreover, LN enhanced the activities of antioxidant enzymes and antioxidant capacity, as measured by enzyme activity assays, RT-PCR, and Western blotting, as well as decreasing the levels of proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-6 and increasing the level of anti-inflammatory (IL-10) in the liver and skeletal muscle. These results suggested that LN reduces both physical and mental effects of chronic fatigue, probably by attenuating oxidative stress injury and inflammatory responses in the liver and skeletal muscle. This study thus supports the use of LN in functional foods for antifatigue and antioxidant effects.

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Anti-fatigue and vasoprotective effects of quercetin-3-O-gentiobiose on oxidative stress and vascular endothelial dysfunction induced by endurance swimming in rats

Cited by 71 publications

References 58 publications

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Anti‐fatigue activity of sea cucumber peptides prepared from Stichopus japonicus in an endurance swimming rat model

Antifatigue Effect of Luteolin‐6‐C‐Neohesperidoside on Oxidative Stress Injury Induced by Forced Swimming of Rats through Modulation of Nrf2/ARE Signaling Pathways

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