Anti-fatigue activity of polysaccharides from the fruits of four Tibetan plateau indigenous medicinal plants

Ni, Wei; Gao, Tingting; Wang, Hailiang; Du, Yuzhi; Li, Jiayu; Li, Cen; Wei, Lixin; Bi, Haibo

doi:10.1016/j.jep.2013.08.055

Cited by 141 publications

(99 citation statements)

References 40 publications

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“…The isolation of polysaccharide HRWP from H. rhamnoides berries was performed as previously described by our group (Ni et al, 2013). Briefly, fresh berries were air-dried and then exhaustively extracted with 95% ethanol to remove hydrophobic compounds.…”

Section: Isolation and Purification Of Polysaccharidesmentioning

confidence: 99%

“…To date, studies on this berry have mainly focused on small molecular compounds of the H. rhamnoides berry, but very few studies have reported on its polysaccharide content (Dongowski, 1996;Ni et al, 2013;Wang et al, 2001). Wang et al (2001) isolated a type of neutral heteropolysaccharide with many branches from H. rhamnoides by alkaline solution.…”

Section: Introductionmentioning

confidence: 99%

“…Wang et al (2001) isolated a type of neutral heteropolysaccharide with many branches from H. rhamnoides by alkaline solution. Recently, our research group isolated a water-soluble polysaccharide (HRWP) from H. rhamnoides berry, which was identified as being a mixture of homogalacturonan and glucan with good anti-fatigue activity (Ni et al, 2013). To further elucidate the constitution, structural features and pharmaceutical values of the water-soluble polysaccharide from the H. rhamnoides berry, further separation, structural analysis and anti-tumor and immunological activity assays were performed in the present study, which is the first such study to do so.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry

Wang

Gao

et al. 2015

Carbohydrate Polymers

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Section: Isolation and Purification Of Polysaccharidesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry

Wang

Gao

et al. 2015

Carbohydrate Polymers

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“…Pharmacological drugs or therapies used for treating fatigue and hypoxia remain unsatisfactory to meet individual requirements effectively. Additionally, the majority of the broad-spectrum drugs exhibit adverse effects (18). Delaying the occurrence of fatigue and hypoxia, and promoting rapid recovery are current foci of medical investigations (7).…”

Section: Introductionmentioning

confidence: 99%

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Wang

Liu

et al. 2015

Molecular Medicine Reports

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Abstract. Paecilomyces hepiali, one of the most valuable and effective Chinese medicinal herbs, possesses potential antioxidant, immunomodulatory, antitumor and anti-inflammatory properties. The present study aimed to investigate the antifatigue and antihypoxic effects of Paecilomyces hepiali extract (PHC) in a mouse model. Using a rotating rod, forced swimming and running assessment, the antifatigue activity of PHC was determined. PHC administration for 7 days had no effect on mouse horizontal or vertical movement, indicating no neurotoxicity at the selected doses was observed. Using a normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia assessments, PHC was confirmed to possess antihypoxic effects. PHC treatment for 7 days significantly enhanced the serum and liver levels of adenosine triphosphate, superoxide dismutase and glutathione peroxidase, prior to and following 60 min of swimming. The levels of antioxidant-associated proteins in the livers of the mice were analyzed using western blotting. PHC effectively increased the expression levels of phosphorylated (p)-5'-monophosphate (AMP)-activated protein kinase (AMPK), p-protein kinase B (AKT) and p-mammalian target of rapamycin (mTOR). The results of the present study demonstrated that PHC efficiently enhanced endurance from fatigue and had antihypoxic effects through elevation of the antioxidant capacity in the serum and liver, at least in part through the AMPK and AKT/mTOR pathways. These results indicate the potential of this natural product as an antioxidant in the treatment of fatigue, hypoxia and their associated diseases.

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“…Excessive energy consumption and the accumulation of metabolic products as a result of physical and mental stress may cause irreversible oxidative tissue damage and lead to depressed immunity, accelerated ageing and cardio-cerebrovascular disease (28,29). The present study identified the anti-fatigue properties of TM in a mouse model by performing forced swimming, rotary rod and exhausted running tests, which are considered to be valid methods of evaluating the exercise capacity of mice (30).…”

Section: Discussionmentioning

confidence: 93%

The anti‑fatigue activities of Tuber melanosporum in a mouse model

Jiang

Chu

et al. 2018

Exp Ther Med

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Abstract. Tuber melanosporum (TM) is an edible fungus that exhibits antioxidant and anti-tumor activity via its unique bioactive metabolites. The present study analyzed the anti-fatigue effects of TM using a BALB/c mouse model. The anti-fatigue properties of TM were evaluated by assessing the endurance of mice by performing forced swimming, rotary rod and running tests. Following 2 weeks TM treatment, hepatic and muscular ATP, and glycogen levels were increased in mice subjected to 30 min swimming, compared with controls. Similarly, levels of serum lactic acid and lactic dehydrogenase were decreased in the same group, compared with the control. Additionally, TM treatment reduced reactive oxygen species and malondialdehyde levels, and increased superoxide dismutase and glutathione peroxidase levels in the muscle, liver and/or serum. The effect of TM on hormone levels was also investigated in the present study, as different efficacies of TM were observed in male and female mice. TM treatment increased serum levels of progesterone, estradiol and testosterone in female and male mice, whereas a decrease in serum luteinizing hormone levels was only observed in females. A decrease in serum follicle-stimulating hormone levels was identified in females, whereas an increase was observed in males. The current study demonstrated that the anti-fatigue effects of TM occur via the regulation of oxidative stress, energy metabolism and hormone levels.

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Anti-fatigue activity of polysaccharides from the fruits of four Tibetan plateau indigenous medicinal plants

Cited by 141 publications

References 40 publications

Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry

Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

The anti‑fatigue activities of Tuber melanosporum in a mouse model

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