Anti-edematogenic effects of velutinol A isolated from Mandevilla velutina: Evidence for a selective inhibition of kinin B1 receptor-mediated responses

Exacerbation of DSS‐induced colitis in mice lacking kinin B1 receptors through compensatory up‐regulation of kinin B2 receptors: the role of tight junctions and intestinal homeostasis

“…To confirm the involvement of the B 1 receptor in DSS‐induced colitis, animals were i.p. treated with DALBK (a peptide selective B 1 receptor antagonist) (Campos et al ., ; McLean et al ., ; Calixto et al ., ; Brunius et al ., ; Leeb‐Lundberg et al ., ; Hamza et al ., ) and SSR240612 (a non‐peptide selective B 1 receptor antagonist) (Gougat et al ., ; Campos et al ., ; Mattos et al ., ). Surprisingly, pretreatment with either DALBK (50 nmol·kg −1 , i.p., twice a day) or SSR240612 (10 mg·kg −1 , p.o., twice a day) were not capable of preventing colitis, and even worsened the DAI (Figure A) and body weight loss (Figure B) following the administration of DSS.…”

Antifungal and antibacterial activity of the floral ethanolic extract of Mandevilla pohliana (Stadelm.) A. H. Gentry

“…All results when positive showed a statistical difference between them and the three antibacterial agents and a reference antifungal agent using the Tukey's test with (P < 0.05). According to Sampaio et al (2021), the Mandevilla genus has several pharmacological applications as venom inhibition, anti-edematogenic and anti-inflammatory activity (BIONDO et al, 2003;MATTOS et al, 2006;ALMEIDA et al, 2017). Thus, it is important to highlight the main biological and pharmacological properties described in the literature was antibacterial and bacteriostatic activity like flavonoids, organic acids, tannins, triterpenoids, phenols, and alkaloids (DUARTE et al, 2014;BARCELOS et al, 2017;CARVALHO et al, 2020;SANTOS et al, 2020).…”

Antinociceptive effects of Maytenus imbricata Mart. ex. Reissek (Celastraceae) root extract and its tingenone constituent

“…Phytochemical investigation have shown that triterpenoids isolated from the Maytenus species exhibit potent inhibitory effects on prostaglandin E 2 (PGE 2 ) production in mice macrophages stimulated with a bacterial endotoxin (Reyes et al, 2006). Mattos et al (2006) observed the anti-edematogenic effects of a steroid isolated from plants that was effective in reducing the edematogenic responses evoked by carrageenan. Moreover, flavonoids play an important role in various biological processes, such as antihepatotoxic, antiallergic, anti-inflammatory, antiosteoporotic and antitumor activities (Di Carlo et al, 1999).…”