Anti-diarrhoeal activity of crude aqueous extract of Rubia tinctorum L. roots in rodents

Abstract

The Anti-diarrhoeal effect of aqueous extract of Rubia tinctorum L. (Rubiaceae) roots in rodents was examined. At doses 300, 600 and 800 mg/kg aqueous extract protected rats, in a dose-dependent fashion, against castor oil-induced diarrhoeal dropping by 37, 59 and 64% respectively. Furthermore, it has significantly inhibited by 41% the gastrointestinal transit of charcoal in mice at 800 mg/kg dose of extract. These data suggest that Rubia tinctorum showed antidiarrhoeal activity by inhibiting intestinal motility which was concordant with its use in traditional medicine.

Studies to determine antidiarrhoeal and spasmolytic activities of extract of Aegle marmelos. L fruit

“…The ricinoleic acid; an active component of castor oil has been demonstrated 27 to stimulate the production of chemical mediators including prostaglandins, nitric oxide, platelet activating factor and cAMP 28 . Castor oil or its active component, ricinoleic acid, intensifies peristaltic activity and induce changes in the permeability of the intestinal mucosal membrane to electrolytes and water 29 .…”

Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat

“…20 However, castor oil produced permeability changes in the intestinal mucosal membrane to water and electrolytes, resulting in watery luminal content that flows rapidly through the small and large intestines. 21,22 The active component of castor oil is the ricinoleic acid, 21 which stimulates the production of several mediator substances that include prostaglandins, nitric oxide, platelet-activating factor, cAMP, and tachykinins. 23 The induction of diarrhea by castor oil can also be attributed to the liberation of prostaglandins by colonic cells.…”

Anti-Diarrheal and Anti-Nociceptive Effects of a Hydroethanolic Leaf Extract of Walnut in Rats

“…Castor oil-induced diarrhea was performed according to the method developed by Karim and colleagues [12]. After 12 days of acclimatization, the rats were randomized into five groups: a negative control, a positive control and three test groups, each containing eight rats.…”