Anti-diabetic effect of ethanol leaf extract of &lt;i&gt;Combretum micranthum&lt;/i&gt; blood glucose and oxidative stress biomarkers on alloxan induced diabetic in wistar rats

Roy

et al. 2023

Plants

Caulophyllum robustum, commonly named Asian blue cohosh, is a perennial herb in the family Berberidaceae. It has traditionally been used for folk medicine in China. We isolated berberine from the leaves, stem, roots, and fruits of C. robustum, and this is the first report on berberine in this species. Transcriptome analysis was conducted for the characterization of berberine biosynthesis genes in C. robustum, in which, all the genes for berberine biosynthesis were identified. From 40,094 transcripts, using gene ontology (GO) analysis, 26,750 transcripts were assigned their functions in the categories of biological process, molecular function, and cellular component. In the analysis of genes expressed in different tissues, the numbers of genes in the categories of intrinsic component of membrane and transferase activity were up-regulated in leaves versus stem. The berberine synthesis genes in C. robustum were characterized by phylogenetic analysis with corresponding genes from other berberine-producing species. The co-existence of genes from different plant families in the deepest branch subclade implies that the differentiation of berberine synthesis genes occurred early in the evolution of berberine-producing plants. Furthermore, the copy number increment of the berberine synthesis genes was detected at the species level.

Section: Discussionmentioning

confidence: 99%

Isolation and Characterization of the Genes Involved in the Berberine Synthesis Pathway in Asian Blue Cohosh, Caulophyllum robustum

Roy

et al. 2023

Plants

Chemistry & Biodiversity

“…There was also a significant decrease (p<0.05) in oxidative stress biomarkers compared to the diabetic control. C. micranthum reduced blood sugar, reactive oxygen free radicals, and improved antioxidant enzyme activities [65] …”

Section: Pharmacological Activitiesmentioning

confidence: 96%

“…C. micranthum reduced blood sugar, reactive oxygen free radicals, and improved antioxidant enzyme activities. [65] Ononamadu et al (2021) identified potential antidiabetic compounds from active subfractions of C. micranthum extracts using in silico techniques. The results validated the antidiabetic potential of the extract and some of the identified compounds exhibiting high binding affinity with the target proteins compared to the reference drug (acarbose).…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Tine,

Sene,

Gaye

et al. 2024

Combretum micranthum (Combretaceae) is a medicinal plant widely known and used in Africa to treat a variety of conditions such as diabetes, fever, coughs, bronchitis, diarrhea, pain, malaria and liver disorders, among others. Due to its wide traditional use, in this review, published scientific reports on its composition and pharmacological properties were explored by conducting a literature search of databases. To date, 155 organic compounds including 34 flavonoids, 16 phenolic acids, 14 alkaloids, 15 fatty acids, 14 terpenoids/steroids, 24 amino acids, 8 carbohydrate substances and 30 other organic compounds have been identified from this plant. In addition to these organic compounds, 6 minerals (potassium nitrate, calcium, magnesium, potassium, sodium, iron and zinc) have also been reported. In vitro and in vivo studies have shown that these phytochemicals and plant extracts have a wide range of pharmacological potential, including antibacterial, antiviral, antioxidant, antidiabetic, anti‐inflammatory, analgesic, antihypertensive, nephroprotective, hepatoprotective, anxiolytic, anti‐cholinesterase and antidiarrheal activities. Additionally, no harmful effects have been revealed through studies. Thus, this study could constitute a valuable reference for the valorization of C. micranthum in the pharmaceutical industry.

“…The antioxidant properties of Abelmoschus esculentus have been revealed by previous research [ 83 , 84 , 85 , 86 ], and this is attributable mainly to its active compounds, such as polyphenols and flavonoids [ 87 ] ( Figure 3 ). Polyphenols mediate antioxidant activity by reducing MDA and increasing SOD, GPx, and catalase activity [ 77 , 78 , 82 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ]. Some of the active polyphenol compounds include isoquercetin, quercetin, quercetin-3-O-gentiobioside, quercetin-3-O-glucoside, protocatechuic acid, and rutin.…”

Section: Abelmoschus Esculentusmentioning

confidence: 99%

“…However, due to reduced CAT activity, beta cells of the pancreas that contain many mitochondria undergo oxidative stress by producing excess ROS that leads to β-cells dysfunction and, ultimately, diabetes [ 18 ]. Interestingly, evidence presented in Table 2 showed that Abelmoschus esculentus treatment in rodent models of diabetes significantly increases CAT activity [ 91 , 95 , 105 , 106 , 113 , 115 , 117 ]. This suggests that Abelmoschus esculentus may ameliorate oxidative stress, further reduce complications of DM, or prevent DM in non-diabetics ( Figure 4 ).…”

Section: Abelmoschus Esculentusmentioning

confidence: 99%

Comprehensive Overview of the Effects of Amaranthus and Abelmoschus esculentus on Markers of Oxidative Stress in Diabetes Mellitus

Phoswa,

Mokgalaboni

2023

Life

The use of medicinal plants in the management of diabetes mellitus (DM) is extensively reported. However, there is still very limited information on the role of these plants as markers of oxidative stress in DM. This current review evaluated the effect of Amaranthus spinosus, Amaranthus hybridus, and Abelmoschus esculentus on markers of oxidative stress in rodent models of DM. Current findings indicate that these plants have the potential to reduce prominent markers of oxidative stress, such as serum malondialdehyde and thiobarbituric acid-reactive substances, while increasing enzymes that act as antioxidants, such as superoxide dismutase, catalase, glutathione, and glutathione peroxidase. This may reduce reactive oxygen species and further ameliorate oxidative stress in DM. Although the potential benefits of these plants are acknowledged in rodent models, there is still a lack of evidence showing their efficacy against oxidative stress in diabetic patients. Therefore, we recommend future clinical studies in DM populations, particularly in Africa, to evaluate the potential effects of these plants. Such studies would contribute to enhancing our understanding of the significance of incorporating these plants into dietary practices for the prevention and management of DM.