Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice

Duan, Huikun; Ma, Bin; Ma, Xiaofeng; Wang, Haisong; Ni, Zaizhong; Wang, Bin; Li, Xiaodan; Jiang, Peng; Umar, Muhammad; Li, Minggang

doi:10.1016/j.ijbiomac.2015.12.049

Cited by 47 publications

(35 citation statements)

References 39 publications

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“…It should be noted that, as of today, there is no evidence that circulating irisin may affect body weight in nondiabetic mice. Moreover, the results on the ability of irisin to reduce body weight and food intake in diabetic mice or rats have been conflicting . Indeed, it is possible that the effects of irisin administration on food intake may be dependent upon the timing and/or route of administration.…”

Section: Discussionmentioning

confidence: 99%

“…Although it was demonstrated that irisin expression is detectable around the paraventricular nucleus region in human hypothalamic sections where it colocalizes with NPY, the potential role of irisin in the regulation of body weight and food intake is still unclear. Indeed, irisin administration has been shown to promote weight loss in diabetic mice or rats, but other studies showed no differences in body weight between diabetic mice receiving irisin or not . As of today, no studies have examined the potential effects of irisin treatment on body weight changes in nondiabetic control mice.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, irisin administration has been shown to promote weight loss in diabetic mice or rats, [17][18][19][20][21][22] but other studies showed no differences in body weight between diabetic mice receiving irisin or not. [23][24][25] As of today, no studies have examined the potential effects of irisin treatment on body weight changes in nondiabetic control mice.…”

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confidence: 99%

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Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Natalicchio

Marrano

Biondi

et al. 2019

Diabetes Metabolism Res

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Background Irisin, a newly discovered muscle‐derived hormone, acts in different organs and tissues, improving energy homeostasis. In this study, we assessed, for the first time, the effects of intraperitoneal irisin injections on circulating levels of leptin and ghrelin, mRNA expression of the major hypothalamic appetite regulators and brain neurotrophic factors, as well as feeding behaviour in healthy mice. Methods Twelve male 6‐week‐old C57BL/6 mice were randomized into two groups and intraperitoneally injected daily with irisin (0.5 μg/g body weight) or vehicle (phosphate‐buffered saline [PBS]) for 14 days. On the last day of observation, leptin and ghrelin levels were measured with an enzyme‐linked immunosorbent assay (ELISA). mRNA levels of genes of interest were analysed by quantitative reverse transcription polymerase chain reaction (qRT‐PCR) in brain extracts. Results Irisin administration did not change leptin or ghrelin serum concentrations. However, irisin injection increased CART, POMC, NPY, and BDNF mRNA levels, without affecting the mRNA expression of AgRP, orexin, PMCH, and UCP2. Finally, over the time frame of irisin treatment, body weight and feeding behaviour were unaltered. Conclusions These results suggest that intraperitoneal injection of irisin, although without effects on feeding behaviour and body weight, can increase the expression of anorexigenic and neurotrophic genes in mouse brain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Natalicchio

Marrano

Biondi

et al. 2019

Diabetes Metabolism Res

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“…Furthermore, overexpression of Fndc5 in obese mice reduced hyperglycaemia, hyperinsulinism, hyperlipidaemia and blood pressure but also enhanced energy expenditure (measured by O 2 consumption, CO 2 heat production and total body activity) and lipolysis (measured by expression of perillipin and HSL, phosphorylation of HSL and adipocyte diameter in SAT and VAT) 74 . Finally, in mice with streptozotocin-induced diabetes, intraperitoneal and oral administration of irisin could reduce glucose levels (~30%) without affecting weight 123 . Taken together, these data indicate that, in mice, irisin can positively affect glucose homeostasis, lipid profile and other metabolic parameters related to obesity.…”

Section: Irisin and Metabolic Diseasesmentioning

confidence: 99%

Physiology and role of irisin in glucose homeostasis

et al. 2017

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Irisin is a myokine that leads to increased energy expenditure by stimulating the ‘browning’ of white adipose tissue. In the first description of this hormone, increased levels of circulating irisin, which is cleaved from its precursor fibronectin type III domain-containing protein 5, were associated with improved glucose homeostasis by reducing insulin resistance. Consequently, several studies attempted to characterize the role of irisin in glucose regulation, but contradictory results have been reported, and even the existence of this hormone has been questioned. In this Review, we present the current knowledge on the physiology of irisin and its role in glucose homeostasis. We describe the mechanisms involved in the synthesis, secretion, circulation and regulation of irisin, and the controversies regarding the measurement of irisin. We also discuss the direct effects of irisin on glucose regulatory mechanisms in different organs, the indirect effects and interactions with other hormones, and the important open questions with regard to irisin in those organs. Finally, we present the results from animal interventional studies and from human clinical studies investigating the association of irisin with obesity, insulin resistance, type 2 diabetes mellitus and the metabolic syndrome.

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“…Oral infection of periodontal pathogens has been generally used to establish periodontitis in experimental mice because of limited oral space [24]. P. gingivalis is widely implicated as an crucial etiological agent in the pathogenesis of periodontitis [25].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Experimental Diabetic Periodontitis Induced byPorphyromonas gingivalisin Mice

Wang

Zhang

Aprecio

et al. 2016

Journal of Diabetes Research

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Periodontitis is one of the severe complications in diabetic patients and gingival epithelium plays an initial role on the onset and progression of this disease. However the potential mechanism is yet sufficiently understood. Meanwhile, the research on the correlational experimental animal models was also insufficient. Here, we established periodontitis with type 2 diabetes in db/db and Tallyho/JngJ (TH) mice and periodontitis with type 1 diabetes in streptozotocin induced diabetes C57BL/6J (STZ-C57) mice by oral infection of periodontal pathogen Porphyromonas gingivalis W50. We demonstrated that periodontal infected mice with high blood glucose levels showed dramatically more alveolar bone loss than their counterparts, in which infected db/db mice exhibited the most bone defects. No contrary impact could be observed between this periodontal infection and onset and severity of diabetes. The expressions of PTPN2 were inhibited whereas the expression of JAK1, STAT1, and STAT3 increased dramatically in gingival epithelia and the serum TNF-α also significantly increased in the mice with diabetic periodontitis. Our results indicated that the variations of inflammation-related protein expressions in gingival epithelia might lead to the phenotype differences in the mice with diabetic periodontitis.

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Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice

Cited by 47 publications

References 39 publications

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Physiology and role of irisin in glucose homeostasis

Comparison of Experimental Diabetic Periodontitis Induced byPorphyromonas gingivalisin Mice

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