Anti-dermatophyte, anti-<i>Fusarium</i>and cytotoxic activity of essential oils and plant extracts of<i>Piper</i>genus

Tangarife-Castaño, Verónica; Correa-Royero, Julieth; Roa-Linares, Vicky C.; Pino-Benítez, Nayive; Betancur‐Galvis, Liliana; Durán, Diego Camilo; Stashenko, Elena E.; Mesa-Arango, Ana Cecilia

doi:10.1080/10412905.2014.882279

Cited by 21 publications

(18 citation statements)

References 23 publications

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“…In addition, the EOs of V. americana and P. hispidum also exhibited significant antifungal activity . Antidermatophytic as well as antimicrobial activity have already been described in the literature for some P. hispidum EOs ( Morales et al 2013 , Tangarife-Castaño et al 2014 ).…”

Section: Discussionmentioning

confidence: 82%

Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products

Houël

González

Bessière

et al. 2015

Mem. Inst. Oswaldo Cruz

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This study examined whether the antidermatophytic activity of essential oils (EOs) can be used as an indicator for the discovery of active natural products against Leishmania amazonensis. The aerial parts of seven plants were hydrodistilled. Using broth microdilution techniques, the obtained EOs were tested against three strains of dermatophytes (Trichophyton mentagrophytes, Microsporum gypseum and Microsporum canis). To compare the EOs antifungal and antiparasitic effects, the EOs activities against axenic amastigotes of L. amazonensis were concurrently evaluated. For the most promising EOs, their antileishmanial activities against parasites infecting peritoneal macrophages of BALB/c mice were measured. The most interesting antifungal candidates were the EOs from Cymbopogon citratus, Otacanthus azureus and Protium heptaphyllum, whereas O. azureus, Piper hispidum and P. heptaphyllum EOs exhibited the lowest 50% inhibitory concentration (IC50) values against axenic amastigotes, thus revealing a certain correspondence between both activities. The P. hispidum EO was identified as the most promising product in the results from the infected macrophages model (IC50: 4.7 µg/mL, safety index: 8). The most abundant compounds found in this EO were sesquiterpenes, notably curzerene and furanodiene. Eventually, the evaluation of the antidermatophytic activity of EOs appears to be an efficient method for identifying new potential drugs for the treatment of L. amazonensis.

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Section: Discussionmentioning

confidence: 82%

Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products

Houël

González

Bessière

et al. 2015

Mem. Inst. Oswaldo Cruz

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“… Monteverde, Costa Rica Leaf (HD) β-Elemene (46.4%), germacrene D (9.5%), bicyclogermacrene (14.1%), germacrene A (13.2%) Cytotoxic (MCF-7 human breast adenocarcinoma) [ 34 ] P. bogotense C. DC. Ipiales, Nariño, Colombia Aerial parts (MWHD) α-Pinene (8.7%), α-phellandrene (13.7%), limonene (5.3%), trans -sabinene hydrate (14.2%) Antitrypanosomal ( T. cruzi epimastigotes, IC 50 10.1 μg/mL); cytotoxic (Vero cells, IC 50 90.1 μg/mL), Antifungal, broth dilution assay ( Trichophyton rubrum , MIC 79 μg/mL; Trichophyton mentagrophytes , MIC 500 μg/mL); cytotoxic (Vero cells, IC 50 25.8 μg/mL) [ 118 , 120 , 121 ] P. brachypodon (Benth.) C. DC.…”

Section: Table A1mentioning

confidence: 99%

“… Monteverde, Costa Rica Leaf (HD) β-Elemene (34.0%), β-caryophyllene (24.2%), germacrene D (21.7%), bicyclogermacrene (14.1%), germacrene A (11.4%) Antibacterial, broth dilution assay ( Bacillus cereus , MIC 78 μg/mL), enzyme inhibitory (cruzain, IC 50 0.96 μg/mL) [ 34 ] P. bredemeyeri Jacq. Pueblo Bello, Cesar, Colombia Aerial parts (MWHD) α-Pinene (20.3%), β-pinene (32.3%), β-caryophyllene (6.3%) Antifungal, broth dilution assay ( Trichophyton rubrum , MIC 157 μg/mL; Trichophyton mentagrophytes , MIC 125 μg/mL); cytotoxic (Vero cells, IC 50 15.2 μg/mL) [ 121 ] P. caldense C. DC. Recife, Pernambuco state, Brazil Leaf (HD) δ-Cadinene (5.6%), thujopsan-2β-ol (7.4%), α-muurolol (9.0%), α-cadinol (19.0%) Antibacterial, agar diffusion assay ( Bacillus subtilis , Staphylococcus aureus , Klebsiella pneumoniae ) [ 54 ] P. caldense C. DC.…”

Section: Table A1mentioning

confidence: 99%

“…C. DC. Pueblo Bello, Cesar, Colombia Aerial parts (MWHD) β-Caryophyllene (8.1%), β-selinene (5.0%), dillapiole (38.8%) Antifungal, broth dilution assay ( Trichophyton mentagrophytes , MIC 500 μg/mL); cytotoxic (Vero cells, IC 50 15.8 μg/mL) [ 121 ] P. fimbriulatum C. DC. Altos de Campana National Park, Panama Leaf (HD) Linalool (5.3%), linalyl acetate (5.3%), β-caryophyllene (11.3%), germacrene D (12.8%) --- [ 111 ] P. fimbriulatum C. DC.…”

Section: Table A1mentioning

confidence: 99%

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Essential Oils from Neotropical Piper Species and Their Biological Activities

Silva

et al. 2017

IJMS

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The Piper genus is the most representative of the Piperaceae reaching around 2000 species distributed in the pantropical region. In the Neotropics, its species are represented by herbs, shrubs, and lianas, which are used in traditional medicine to prepare teas and infusions. Its essential oils (EOs) present high yield and are chemically constituted by complex mixtures or the predominance of main volatile constituents. The chemical composition of Piper EOs displays interspecific or intraspecific variations, according to the site of collection or seasonality. The main volatile compounds identified in Piper EOs are monoterpenes hydrocarbons, oxygenated monoterpenoids, sesquiterpene hydrocarbons, oxygenated sesquiterpenoids and large amounts of phenylpropanoids. In this review, we are reporting the biological potential of Piper EOs from the Neotropical region. There are many reports of Piper EOs as antimicrobial agents (fungi and bacteria), antiprotozoal (Leishmania spp., Plasmodium spp., and Trypanosoma spp.), acetylcholinesterase inhibitor, antinociceptive, anti-inflammatory and cytotoxic activity against different tumor cells lines (breast, leukemia, melanoma, gastric, among others). These studies can contribute to the rational and economic exploration of Piper species, once they have been identified as potent natural and alternative sources to treat human diseases.

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“…To the best of our knowledge, there are no previous reports concerning either the chemical composition or the biological activities of the essential oils from P. corrugatum, P. curtispicum, P. darienense, P. grande, P. longispicum, and P. trigonum, whereas the essential oil composition of the other five species, P. augustum, P. hispidum, P. jacquemontianum, P. multiplinervium, and P. reticulatum collected in other Latin American countries, has been previously described. Biological activities, such as antifungal, antileishmanial, and anticholinesterase properties, have only been investigated for the essential oils of P. hispidum [13,[19][20][21] and P. multiplinervium [22]. The objective of the present paper was to investigate the composition of the essential oils of the leaves of these species growing in Panama and the antifungal and mosquito larvicidal activity of some of them.…”

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confidence: 99%

Chemical Composition and Biological Activity of Essential Oils from Different Species of Piper from Panama

et al. 2016

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The chemical composition of leaf essential oils from 11 species of Piper from Panama was analyzed by a combination GC-FID and GC-MS procedures. Six of them had sesquiterpene hydrocarbons as major constituents, three were characterized by monoterpene hydrocarbons, one by a diterpene, and one by a phenylpropanoid, dillapiole. The main components identified in each species were: cembratrienol (25.4 %) in Piper augustum; β-pinene (26.6 %) in Piper corrugatum; α-pinene (19.4 %) in Piper curtispicum; trans-β-farnesene (63.7 %) in Piper darienense; p-cymene (43.9 %) in Piper grande; dillapiole (57.7 %) in Piper hispidum; linalool (14.5 %), α-phellandrene (13.8 %), and limonene (12.2 %) in Piper jacquemontianum; β-caryophyllene (45.2 %) in Piper longispicum; linalool (16.5 %), α-phellandrene (11.8 %), limonene (11.4 %), and p-cymene (9.0 %) in Piper multiplinervium; β-selinene (19.0 %), β-elemene (16.1 %), and α-selinene (15.5 %) in Piper reticulatum; and germacrene D (19.7 %) in Piper trigonum. The essential oils of P. hispidum and P. longispicum at a concentration of 250 µg/mL showed larvicidal activity against Aedes aegypti, while the oils from P. curtispicum, P. multiplinervium, P. reticulatum, and P. trigonum were inactive (LC100 ≥ 500 µg/mL). The essential oils of P. grande, P. jacquemontianum, and P. multiplinervium showed no significant antifungal activity (MIC > 250 µg/mL) against several yeasts and filamentous fungal strains.

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Anti-dermatophyte, anti-Fusariumand cytotoxic activity of essential oils and plant extracts ofPipergenus

Cited by 21 publications

References 23 publications

Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products

Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products

Essential Oils from Neotropical Piper Species and Their Biological Activities

Chemical Composition and Biological Activity of Essential Oils from Different Species of Piper from Panama

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