Anti-cancer effects of polyphenol-rich sugarcane extract

Prakash, Monica D.; Stojanovska, Lily; Feehan, Jack; Nurgali, Kulmira; Donald, Elizabeth; Plebanski, Magdalena; Flavel, Matthew; Kitchen, Barry J.; Apostolopoulos, Vasso

doi:10.1371/journal.pone.0247492

Cited by 23 publications

(17 citation statements)

References 40 publications

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“…The anti-cancer properties of natural plant-derived antioxidants have been demonstrated in vitro in relation to various cell lines of breast, skin, colon, prostate, lung and bladder cancers and leukemia [ 13 , 14 , 15 ]. Acting as bioactive compounds, the polyphenols affect the process of the expression of many genes, and the molecular mechanism of their action is mainly associated with the redox homeostasis of cells, inflammation, the cell cycle and the apoptosis regulation and modulation of the essential cell signaling pathways [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field

Kimsa-Dudek

Synowiec-Wojtarowicz

Krawczyk

et al. 2022

IJMS

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The induction of apoptosis is one of the main goals of the designed anti-cancer therapies. In recent years, increased attention has been paid to the physical factors such as magnetic fields and to the natural bioactive compounds and the possibilities using them in medicine. Hence, the aim of this study was to evaluate the anti-tumor effect of caffeic or chlorogenic acid in combination with a moderate-strength static magnetic field on C32 melanoma cells by assessing the effect of both factors on the apoptotic process. The apoptosis of the C32 cells was evaluated using a flow cytometry analysis. The expression of the apoptosis-associated genes was determined using the RT-qPCR technique. The caspase activity and the concentration of the oxidative damage markers were also measured. It was found that phenolic acids and a static magnetic field trigger the apoptosis of the C32 cells and also affect the expression of the genes encoding the apoptosis regulatory proteins. In conclusion, our study indicated that both of the phenolic acids and a static magnetic field can be used supportively in the treatment of melanoma and that caffeic acid is more pro-apoptotic than chlorogenic acid.

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Section: Discussionmentioning

confidence: 99%

The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field

Kimsa-Dudek

Synowiec-Wojtarowicz

Krawczyk

et al. 2022

IJMS

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“…Anti-proliferative effects were shown to be mediated via alteration in cytokines, VEGF-1 and NF-κB expression. 28 Rubin-Garcia et al showed that a diet high in polyphenol compounds like stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower gastric cancer risk. 29 Olive oil polyphenols (OOPs), especially hydroxytyrosol (HTyr), tyrosol (Tyr) and their derivatives oleuropein (Ole), express anticancer activity on different cancer models.…”

Section: Discussionmentioning

confidence: 99%

Quantification of total polyphenols and flavonoids, antioxidant activity, and Sinensetin and Imperatorin contents of Imperata cylindrica root ethanol extract

Indriyanti¹,

Ariyanto²,

Usman³

et al. 2022

Pharmacogn. J.

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Introduction: Imperata cylindrica, commonly known as cogon grass, is currently widely distributed and used as a medicinal plant. The major compounds that have been isolated and identified are polyphenols and flavonoids, which have many biological activities such as antioxidant, and anticancer. Polyphenols and flavonoids are mostly found in the roots and leaves. This study aimed to perform phytochemical screening on I. cylindrica root ethanol extract from Sragen, Central Java, Indonesia and determine the total polyphenol, flavonoid, antioxidant activity and quantify Sinensetin and Imperatorin contents of the extract. Method: Quantification of all parameters were measured using visible spectrophotometric methods. Total polyphenol, total flavonoid contents, as well as antioxidant activity were measured using Folin-Ciocalteu reagent, aluminum chloride reagent, and 1,1-diphenyl-2-picrylhydrazyl, respectively, and quantification of Sinensetin and Imperatorin were measured using High Performance Liquid Chromatography. Results: I cylindrica root ethanol extract had a total polyphenol content of 1.109% gallic acid equivalent, total flavonoid content of 0.1% quercetin equivalent, and antioxidant activity IC 50 824.30 µg/ml. Sinensetin and Imperatorin were also identified in Fractions 1 to 11 with concentrations of 0.0157 and 0.0178 mg/kg extract, respectively. Conclusion: I. cylindrica root ethanol extract from Sragen had active phytochemical compounds of polyphenols, flavonoids, and antioxidants as well as Sinensetin and Imperatorin.

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“…Cells were processed for downstream analysis after 24 h in culture. PRSE at 400 µg/mL was chosen based on previous in vitro experiments on modulation and anti-inflammatory effects of cancer cell lines [27]. All analyses were performed on three technical replicates, and with sample means presented.…”

Section: Treatment Groupsmentioning

confidence: 99%

“…It is also able to impart benefits in diabetes, has anti-bacterial effects and improves the cosmetic effects of aging in the skin [25]. PRSE has also been shown to modulate the immune system, with effects on inflammation, cancer and neurological disorders [26,27].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes

et al. 2021

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As inflammatory lifestyle factors become more prevalent and as the population ages, the management of inflammation will become increasingly relevant. Plant polyphenols are powerful antioxidants that are known to have beneficial effects in a number of diseases with an inflammatory or oxidative component, such as malignancy, cardiovascular disease and arthritis. Polyphenol-rich sugarcane extract (PRSE) is a novel preparation with high concentrations of polyphenolic antioxidants, with some evidence to show benefits in health, but there is limited research investigating its effects on immunomodulation. This study determined the effects of PRSE on human monocyte cells in vitro. We show that PRSE has an immunomodulatory effect in U937 human monocyte cells, altering the expression of cellular surface markers, with an increased expression of CD16 and CD11b, as well as small changes in CD40, CD80, CD80, CD206 and MHCI. It also modulates the profile of secreted cytokines, increasing IL-1β, TNFα, IL-6, IL-8, IL-4 and IL-10. These changes are consistent with the advanced differentiation of the monocyte, as well as the switch from the M1 to M2 phenotype in macrophages. We also demonstrate that this effect is likely to be independent of the NF-κB signalling pathway, suggesting that other mechanisms drive this effect. PRSE exerts an immunomodulatory effect on U937 monocytes in vitro, potentially facilitating the conversion from inflammation to healing. Future studies should identify specific mechanisms underlying the changes and evaluate their effectiveness in animal models of disease.

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Anti-cancer effects of polyphenol-rich sugarcane extract

Cited by 23 publications

References 40 publications

The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field

The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field

Quantification of total polyphenols and flavonoids, antioxidant activity, and Sinensetin and Imperatorin contents of Imperata cylindrica root ethanol extract

Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes

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