Anti-Cancer Effect of UV Irradiation at Presence of Cadmium Oxide (CdO) Nanoparticles on DNA of Cancer Cells: A Photodynamic Therapy Study

Heidari, Alireza

doi:10.21767/2254-6081.100061

Cited by 33 publications

(21 citation statements)

References 20 publications

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“…In the present study, the number of total WBC, blasts, eosinophil, neutrophil, monocyte, omit the free radicals of hematotoxic substances and inhibit their toxic effects [50][51][52]. Also, many studies similar to our study revealed significant antioxidant effects of cadmium nanoparticles [10,11].…”

Section: In Vivo Anti-acute Myeloid Leukemia Properties Of Cdnpssupporting

confidence: 60%

“…Through the cell membrane, nanoparticles harmful to the essential enzymes of bacteria can be the basis of the antibacterial properties of these nanoparticles [5,6]. Also, the metallic nanoparticles have excellent potentials in the treatment of several cancers especially leukemia [7][8][9][10][11]. In this regard, in the work of Hemmati et al (2019) proved that metallic nanoparticle-chitosan composite had excellent anti-acute myeloid leukemia in the in vivo and in vitro conditions.…”

Section: Introductionmentioning

confidence: 99%

“…In a study, Hossain and Mukherjee (2013) presented the excellent potential of cadmium nanoparticles in removing human cervical adenocarcinoma cells (HeLa) [10]. Also, in the other study, Heidari (2016) indicated the significant role of cadmium nanoparticles in combination with UV radiation in the removing of tissue tumors [11]. Recently, scientists have used the anti-acute leukemia effects of medicinal plants for synthesizing the metallic nanoparticles containing natural compounds.…”

Section: Introductionmentioning

confidence: 99%

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Formulation a modern chemotherapeutic drug of Ziziphora clinopodides Lam leaf aqueous extract conjugated cadmium nanoparticles and analysis of their anti-acute myeloid leukemia potentials in comparison to Daunorubicin in leukemic mouse and cellular models: Antidiabetic and Anticholinergics Potentials

Mahdavi

Zangeneh

Paydarfar

et al. 2020

Preprint

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In this study, the anti-acute myeloid leukemia (AML) effects of Ziziphora clinopodioides Lam leaf aqueous extract conjugated cadmium nanoparticles (CdNPs) were compared with daunorubicin as a common chemotherapeutic drug. To synthesize CdNPs, Z. clinopodioides aqueous extract was combined with Cd(NO 3 ) 2 .4H 2 O. For analyzing CdNPs, SEM, UV-Vis. spectroscopy, X-ray powder diffraction and Energy dispersing X-ray spectroscopy, Fourier Transform Infrared techniques were used. In FE-SEM images of CdNPs, the diameter of particle dimension was on means of 26.78 nm. To survey the cytotoxicity and anti-AML effects of Cd(NO 3 ) 2 , Z. clinopodioides, Daunorubicin, CdNPs and MTT assay was used on the human AML cell lines. The IC50 of the cadmium nanoparticles was 168, 205 and 210 µg/mL against Murine C1498, 32D/FLT3-ITD and Human HL-60/vcr cell lines, respectively. In vivo study, CdNPs like daunorubicin ameliorated importantly (P≤0.01) the biochemical, WBC, RBC, inflammatory, platelet, stereological, histopathological and cellular-molecular parameters compared to the other groups. As mentioned, the cadmium nanoparticles had significant anti-AML effects. After approving the above eventuate in the clinical trial studies, these cadmium nanoparticles could be used in humans as a chemotherapeutic medicament for the treatment of AML. Additionally, the novel nanoparticles (Cd(NO 3 ) 2 and CdNPs) were good inhibitors of the α-glycosidase, and cholinesterase enzymes.

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Section: In Vivo Anti-acute Myeloid Leukemia Properties Of Cdnpssupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Formulation a modern chemotherapeutic drug of Ziziphora clinopodides Lam leaf aqueous extract conjugated cadmium nanoparticles and analysis of their anti-acute myeloid leukemia potentials in comparison to Daunorubicin in leukemic mouse and cellular models: Antidiabetic and Anticholinergics Potentials

Mahdavi

Zangeneh

Paydarfar

et al. 2020

Preprint

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“…Heavy metals Nano compounds are important synthetic intermediates in organic, medicinal and pharmaceutical chemistry and are valuable in the preparation of biologically and pharmaceutically relevant Nano materials [1][2][3][4][5][6][7][8][9][10][11] . The oxidation of heavy metals Nano compounds is the most straight forward method for the synthesis of heavy metals Nano compounds [12][13][14][15][16][17][18][19][20][21][22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation

Heidari¹,

Internationals²

2017

LHBS

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“…Neglecting the overall charge of the macro cycle, monomeric free-base DNA/RNA complexes in aqueous solution can add protons. The composition of the complex was recognized by bio-spectroscopic techniques such as Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR), FT-Raman, UV-Vis, HR Mass, 1 HNMR, 13 CNMR and 31 PNMR bio-spectroscopies. The equilibrium constant (K) was found to be 6-12.…”

mentioning

confidence: 99%

Human Toxicity Photodynamic Therapy Studies on DNA/RNA Complexes as a Promising New Sensitizer for the Treatment of Malignant Tumors Using Bio-Spectroscopic Techniques

Heidari¹

2016

J Drug Metab Toxicol

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EditorialDNA/RNA complexes play an important role in many biological and catalytic systems. The variety of their functions is due in part to the diversity of metals that bind in the "pocket" of the DNA/RNA complexes system. In this editorial, we discuss synthesis and recognition of DNA/RNA complexes and argue group theory of them. Upon metalation the DNA/RNA complexes system deprotonates, forming a dianionic ligand. The metal ions behave as Lewis acids, accepting lone pairs of electrons from the dianionic DNA/RNA ligand. Unlike most transition metal complexes, their color is due to absorption(s) within the DNA/RNA ligand involving the excitation of electrons from π to π * (π→π * ) DNA/RNA complexes orbitals. Most DNA/RNA complexes contain a metal ion in the center of the planner DNA/RNA complexes system, resulting in a kinetically inert complex. If, however, the ionic radius of the metal ions is too large to fit into the hole in the center of the macro cycle, they are located out of the ligand plane, distorting it. These kinetically labile Sitting-Atop (SAT) complexes display characteristic structural and photo induced properties that strongly deviates from those of the regular DNA/RNA complexes .In addition, DNA/RNA complexes functional unit is located in the photosynthetic reaction center and play an important role in biological process such as light energy conversion, Oxygen transport and catalysis. Studies on water-soluble and insoluble DNA/RNA complexes have elucidated aspects of the mechanisms of metal ion incorporation into DNA/RNA to form DNA/RNA complexes. Neglecting the overall charge of the macro cycle, monomeric free-base DNA/RNA complexes in aqueous solution can add protons. The composition of the complex was recognized by bio-spectroscopic techniques such as Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR), FT-Raman, UV-Vis, HR Mass, 1 HNMR, 13 CNMR and 31 PNMR bio-spectroscopies. The equilibrium constant (K) was found to be 6-12. It should be noted that a possible mechanism is discussed in details.On the other hand, DNA/RNA complexes are biochemically important, medically useful and synthetically interesting compounds. In general, there are several routes that can be followed to afford DNA/RNA complexes such as tetramerization, synthesis of DNA/RNA complexes, condensation of DNA/RNA complexes and cyclization of open chain DNA/RNA compounds. The mechanism of Photodynamic Therapy (PDT) has been mentioned as well.Furthermore, the synthesis of water-soluble DNA/RNA complexes has been discussed. This synthesis includes condensation, followed by metal insertion, oxidation, demetallation and deboronation reactions.This compound accumulated within human glioblastoma U87MG cells to a significant higher extent than structurally related DNA/RNA complexes and localized preferentially in the cell lysosomes. Human toxicity studies are shown that both compounds are non-toxic even at a dose of 250 mg/kg. It is concluded that the DNA/RNA complexes is a promising new sensitizer for th...

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Anti-Cancer Effect of UV Irradiation at Presence of Cadmium Oxide (CdO) Nanoparticles on DNA of Cancer Cells: A Photodynamic Therapy Study

Cited by 33 publications

References 20 publications

Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation

Human Toxicity Photodynamic Therapy Studies on DNA/RNA Complexes as a Promising New Sensitizer for the Treatment of Malignant Tumors Using Bio-Spectroscopic Techniques

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