Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation

Heidari, Alireza; Internationals, Ommega

doi:10.15436/2475-6245.17.019

Cited by 15 publications

(4 citation statements)

References 26 publications

(16 reference statements)

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“…The amount of drug loading and percentage and manner of the drug release were investigated using concentration profile. Cytotoxicity of Nano drug carrier was evaluated using calorimetric method called methylthiazoletetrazolium (MTT) assay on the MCF-7 cell lines and according to the results presented system is very profitable and proper one for delivering Doxorubicin anti-cancer drug [74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93].…”

Section: Manifestations Of Hereditary Immunity In Cancer 21 In First Discovery Of Hereditary Immunity To Cancermentioning

confidence: 99%

Hereditary immunity in cancer

Heidari

Schmitt

Henderson

et al. 2020

IJAC

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Cancer is one of the malignant diseases and millions of people worldwide die from cancer annually. Breast cancer diagnosis requires the analysis of images and attributes as well as collecting many clinical and mammography variables. In diagnosis of breast cancer, it is im-portant to determine whether a tumor is benign or malignant. The information about breast cancer risk prediction along with the type of tu-mor are crucial for patients and effective medical decision making. An ideal diagnostic system could effectively distinguish between benign and malignant cells; however, such a system has not been created yet. In this study, a model is developed to improve the prediction probabil-ity of breast cancer. It is necessary to have such a prediction model as the survival probability of breast cancer is high when patients are diagnosed at early stages.

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Section: Manifestations Of Hereditary Immunity In Cancer 21 In First Discovery Of Hereditary Immunity To Cancermentioning

confidence: 99%

Hereditary immunity in cancer

Heidari

Schmitt

Henderson

et al. 2020

IJAC

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“…If the pumping intensity exceeds the threshold of this effect, it observes [66]- [81]. The pumping threshold limit for stimulated ATR-FTIR depends on ATR-FTIR active material [82]- [98]. Regarding the spectral characteristics, stimulated ATR-FTIR can be distinguished from normal ATR-FTIR [1] In the current research, the stimulated ATR-FTIR spectrum is obtained through pumping the second harmonic beam laser Nd:YAG and it is performed by a spectrometer and detector.…”

Section: Introductionmentioning

confidence: 99%

<i>In Situ</i> Characterization of Lopinavir by ATR-FTIR Biospectroscopy

Heidari¹

2020

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Lopinavir is an antiretroviral of the protease inhibitor class (Figure 1 and Figure 2). It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated ATR-FTIR biospectroscopy of liquid sample of Lopinavir was investigated. The stimulated ATR-FTIR diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) led to increase in stimulated ATR-FTIR signal but after breakdown threshold of liquid sample, further increasing energy led to the decrease in stimulating ATR-FTIR signals and for energies higher than 20 (mJ), they were disappeared. Figure 1. Molecular structure of Lopinavir.

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“…With the growth and expansion of the science of biology and the greater understanding of cell biology, it became clear that biochemical factors are not the only factors involved in cell fate [59][60][61][62][63][64][65][66][67][68][69][70]. With the extensive research done in this field, they concluded that in order to imitate the cell membrane to achieve a specific goal, in addition to biochemical factors, it is also necessary to control biophysical factors such as mechanical, geometric and electrical factors [71][72][73][74][75][76][77][78][79][80][81]. The electrical properties of the field are a fundamental issue in cell-biomaterial interaction.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the inverse piezoelectric effect of synchrotron light source imaging of electrical stimulation on the fate of nano stem cells and its role and application in regenerative medicine and cancer treatment

Heidari

Torfeh²,

Iorgulescu³

et al. 2022

IJAC

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The presence of electrical activity in body organs such as the nervous system, heart and bones has caused one of the most widely used treatment methods called electrotherapy to be widely used, especially in the relief of underlying pain. On the other hand, the progress of medical science in the field of nano stem cells and regenerative medicine has created many promises in treatment. Also, recently, treatments based on electric field have been widely used in cancer treatment. The main issues in regenerative medicine are the proliferation of nano stem cells to the required extent and directing them towards the differentiation of the target tissue. Electric field (EF) stimulation can play an important role in creating appropriate nano stem cell responses and directing nano stem cell differentiation towards osteogenesis/neuronogenesis/cardiomyogenesis. The electric field with nanosecond pulse as well as the electric field for tumor therapy have attracted a lot of attention for the treatment of cancer. Major signaling pathways and cellular responses elicited by electrical stimulation include reactive oxygen species and heat shock proteins, fluctuations in intracellular calcium ion concentration, ATP production, clustering or reaggregation of cell surface receptors., reconstruction of the cytoskeleton that affect the fate of the nano stem cell. Also, the lack of pain, ease and reasonable price have made cancer treatment with electric field more and more popular. In this research, an attempt has been made to briefly review the effects of electrical signals on the behavior of nano stem cells, as well as examples of their therapeutic effects in the treatment of tissue lesions and cancer. Schematic of the inverse piezoelectric effect of synchrotron light source imaging of electrical stimulation on the fate of nano stem cells and its role and application in regenerative medicine and cancer treatment.

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Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation

Cited by 15 publications

References 26 publications

Hereditary immunity in cancer

Hereditary immunity in cancer

<i>In Situ</i> Characterization of Lopinavir by ATR-FTIR Biospectroscopy

Investigation of the inverse piezoelectric effect of synchrotron light source imaging of electrical stimulation on the fate of nano stem cells and its role and application in regenerative medicine and cancer treatment

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Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation

Cited by 15 publications

References 26 publications

Hereditary immunity in cancer

Hereditary immunity in cancer

&lt;i&gt;In Situ&lt;/i&gt; Characterization of Lopinavir by ATR-FTIR Biospectroscopy

Investigation of the inverse piezoelectric effect of synchrotron light source imaging of electrical stimulation on the fate of nano stem cells and its role and application in regenerative medicine and cancer treatment

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Product

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<i>In Situ</i> Characterization of Lopinavir by ATR-FTIR Biospectroscopy