Anti-cancer activities of S-allylmercaptocysteine from aged garlic

Lv, Yi; So, Kwok-Fai; Wong, Nai-Kei; Xiao, Jia

doi:10.1016/s1875-5364(19)30008-1

Cited by 24 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, the apoptotic effect of A. subhirsutum was time- and concentration-dependent. Similarly, previous studies reported that exposure of cancer cells to plant natural products induced apoptotic cell death [ 40 , 41 ]. Millimouno et al [ 40 ] reported that natural compounds could target apoptosis pathways in cancer.…”

Section: Resultsmentioning

confidence: 59%

Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study

et al. 2020

View full text Add to dashboard Cite

This study investigated Allium subhirsutum L. (AS) anticancer and antioxidant effects and inhibition of tumor angiogenesis in a murine model of skeletal metastases due to inoculation of Walker 256/B cells. Phytochemical composition of AS extract (ASE) was studied by High Resolution-Liquid Chromatography Mass Spectroscopy (HR-LCMS). Total phenolic and flavonoid contents (TPC and TFC) were determined. In vitro, the antioxidant properties were evaluated by reducing power and antiradical activity against DPPH. Cancer cells’ proliferation, apoptosis, metastatic development and angiogenesis were evaluated using Walker 256/B and MatLyLu cells. The p-coumaric acid was the major phenolic acid (1700 µg/g extract). ASE showed high levels of TPC and TFC and proved potent antioxidant effects. ASE inhibited Walker 256/B and MatLyLu cells’ proliferation (Half-maximal inhibitory concentration: IC50 ≃ 150 µg/mL) and induced apoptosis. In silico and in vivo assays confirmed these findings. ASE effectively acts as a chemo-preventive compound, induces apoptosis and attenuates angiogenesis and osteolytic metastases due to Walker 256/B malignant cells.

show abstract

Section: Resultsmentioning

confidence: 59%

Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The therapeutic effects of garlic are mainly due to the impressive activity of its bioactive compounds, such as organic sulfides [ 3 ], saponins [ 4 ], phenolic compounds [ 5 ], and polysaccharides [ 6 ]. For example, several in vitro and in vivo studies have showed that garlic compounds are able to modulate various signaling pathways, including nuclear factor-κB and wingless-related integration site [ 7 ], matrix metalloproteinases, nuclear factor erythroid 2 like 2, protein kinase B (pAkt), mitogen-activated protein kinase, c-Jun N-terminal kinases, caspases, p38, transforming growth factor beta 1 (TGF-β1), TGF-β type II receptor, psmad2/3, smad4 and smad7 [ 8 , 9 ], cytokines, intercellular adhesion molecule [ 10 ], notch pathway [ 11 ], 5’ AMP-activated protein kinase pathway [ 12 ], vascular endothelial growth factor [ 13 ], cyclooxygenase 2, inducible nitric oxide synthase, Akt/mTOR [ 14 ], and Keap1 [ 15 ], leading to improved anti-inflammatory and antioxidant properties, as well as chemopreventive, antiproliferative, anti-angiogenic, antidiabetic, and cardioprotective effects. However, it should be taken into account that these compounds have a very low availability.…”

Section: Introductionmentioning

confidence: 99%

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

et al. 2020

View full text Add to dashboard Cite

Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed.

show abstract

“…As we can see from the table 1, SAMC and SAC demonstrated to a suppressive agent against several tumours and they have several functions such as antiinflammatory, antibacterial, and antiviral, antioxidant, cardiovascular protective. [10][11][12][13][14][15][16][17][18][19][20] Sallylcysteine ( SAC) and S-allylmercaptocysteine (SAMC) have a high value of 0.96-0.98 Pa (probability to be active) in human flavin-containing monooxygenase 3 (FMO3) and it has impact on enzyme activity, drug metabolism and disease. [28][29] Indeed, A flavin-containing monooxygenase (FMO) produced by A. sativum (AsFMO) was previously proposed to oxidize Sallyl-L-cysteine (SAC) to alliin, an allicin precursor.…”

Section: Fig 4 Prediction Of Activity Spectra For Substances Calculated : the Output File Represents A List Of Activities With Two Probabmentioning

confidence: 99%

Open access in silico tools to predict the ADMET profiling and PASS (Prediction of Activity Spectra for Substances of Bioactive compounds of Garlic (Allium sativum L.)

Ferrari

2021

Preprint

View full text Add to dashboard Cite

Background: Garlic (Allium sativum L.) is a common spice with many health benefits, mainly due to its diverse bioactive compounds, (see below) such as organic sulphides, saponins, phenolic compounds, and polysaccharides. Several studies have demonstrated its functions such as anti-inflammatory, antibacterial, and antiviral, antioxidant, cardiovascular protective and anticancer property. In this work we have investigated the main bioactive components of garlic through a bioinformatics approach. Indeed, we are in an era of bioinformatics where we can predict data in the fields of medicine. Approaches with open access in silico tools have revolutionized disease management due to early prediction of the absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles of the chemically designed and eco-friendly next-generation drugs. Methods: This paper encompasses the fundamental functions of open access in silico prediction tools, as PASS database (Prediction of Activity Spectra for Substances) that it estimates the probable biological activity profiles for compounds. This paper also aims to help support new researchers in the field of drug design and to investigate best bioactive compounds in garlic. Results: Screening through each of pharmacokinetic criteria resulted in identification of Garlic compounds that adhere to all the ADMET properties. Conclusions: It was established an open-access database (PASS database, available bioinformatics tool SwissADME, PreADMET pkCSM database) servers were employed to determine the ADMET (metabolism, distribution, excretion, absorption, and toxicity) attributes of garlic molecules and to enable identification of promising molecules that follow ADMET properties.

show abstract

Anti-cancer activities of S-allylmercaptocysteine from aged garlic

Cited by 24 publications

References 39 publications

Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study

Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

Open access in silico tools to predict the ADMET profiling and PASS (Prediction of Activity Spectra for Substances of Bioactive compounds of Garlic (Allium sativum L.)

Contact Info

Product

Resources

About