Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines

Abstract

Chronic joint pain due to loss of cartilage function, degradation of subchondral bone, and related conditions are common plights of an arthritis patient. Antioxidant compounds could solve the problems in arthritic condition. The objective of this study was to evaluate the anti-arthritic activity of D-carvone against complete Freund’s adjuvant (CFA)-induced arthritis in rats. D-carvone was orally administered for 25 days at the doses of 30 and 60 mg/kg against CFA-induced arthritic rats. Changes in body weight, paw swelling, organ index, hematological parameters, oxidative stress markers, inflammatory cytokines, and histopathology were recorded. Oral treatment of D-carvone significantly improved the body weight, reduced the paw swelling, edema formation, and organ index in arthritic rats. The levels of white blood cells were reduced, red blood cells and hemoglobin levels were improved in D-carvone treated arthritic rats. Lipid peroxidation levels were lowered whereas enzymatic and non-enzymatic antioxidants were significantly elevated by D-carvone administration against arthritic rats. D-carvone significantly modulated inflammatory cytokine levels and improved the ankle joint pathology against CFA-induced arthritic inflammation. In conclusion, D-carvone proved significant anti-arthritic activity against CFA-induced arthritis in rats.

Antioxidant, anti-cancer and anti-arthritic activities of acetogenin-rich extract of avocado pulp

“…Low and high dose of acetogeninrich extract of avocado pulp showed significant decrease in spleen weight and spleen % compared with arthritic control but still significantly higher than normal control. The present results are in agreement with the results of Chen et al [50]. Spleen is important organ for immune response and regulation, which acts to produce immune cells and filters the dead cells [50,51].…”

“…Spleen is important organ for immune response and regulation, which acts to produce immune cells and filters the dead cells [50,51]. Increase in the organ index of spleen in arthritic rats could be explained with the filtration of immune cells along with dead RBCs and WBCs (Chen et al, 2020).…”

Health Benefits and Pharmacological Properties of Carvone

“…In a study conducted on arthritic rats, Chen et al [ 107 ] evaluated the anti-arthritic activity of D -carvone against arthritis induced by Freund’s complete adjuvant (FCA) in rats. Following oral administration of D -carvone for 25 days at doses of 30 mg/kg and 60 mg/kg against FCA-induced arthritic rats, certain changes were observed, namely, improvement in body weight, reduction in leg swelling, edema formation, and organ index in these arthritic rats.…”

Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone

“…Carvone is a terpenoid found in many plant essential oils but is most abundant in caraway, spearmint, and dill. It is a known antimicrobial [ 40 , 41 ], anti-inflammatory [ 42 , 43 ], anti-arthritis [ 44 ], anticancer [ 45 ], liver-protective [ 46 ], cardioprotective [ 47 ], calming and neuroprotective [ 48 , 49 , 50 ] agent. It is also an anticonvulsant, suggested as a potential treatment for epilepsy [ 51 ].…”